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  • Springer  (3)
  • Köln : Universität zu Köln, Medizinische Fakultät, Experimentelle Pädiatrische Onkologie  (1)
  • PUBLIC LIBRARY SCIENCE  (1)
  • 1
    Online Resource
    Online Resource
    Systemmedizin beim Neuroblastom - SYSMED-NB : Teilprojekt(e): A1, B2 : Forschungskonsortien zur Systemmedizin; e:Med-Initiative : Schlussbericht über den Projektverlauf vom 01.08.2017 bis 31.07.2019 (2019)
    Köln : Universität zu Köln, Medizinische Fakultät, Experimentelle Pädiatrische Onkologie
    Details Availability
    Keywords: Forschungsbericht ; Neuroblastom ; Kind ; Systemmedizin ; Molekulare Medizin ; Ras ; Telomerase ; Genanalyse
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (11 Seiten, 120,23 KB) , Diagramme
    URL: https://doi.org/10.2314/KXP:1700725637
    DOI: 10.2314/KXP:1700725637
    Language: German
    Note: Förderkenneichen BMBF 01ZX1607D , Verbundnummer 01178522 , Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden , Sprache der Zusammenfassung: Deutsch, Englisch
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  • 2
    Electronic Resource
    Electronic Resource
    Radiogene Morphaea (1999)
    Springer
    Der Hautarzt 50 (1999), S. 507-510 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Morphaea ; Radiotherapie ; Radioderm ; Mukophanerose ; Key words Morphoea ; Radiotherapy ; Radiodermatitis ; Mucophanerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Although the aetiology of morphea often remains unknown, various precipitating causes have been identified. Morphea is a rare development following irradiation. We observed a circumscribed scleroderma 14 years after x-ray-radiotherapy following surgery of breast cancer. Furthermore multiple weeping papules occured within the radiation area. A relapse of the breast cancer was ruled out by histological examination which displayed a transepidermal elimination of acid mucin. The irradiation had obviously induced different reactions of the dermal fibroblasts (radiodermatitis, morphea, mucin production).
    Notes: Zusammenfassung Hinsichtlich der Ätiologie der Morphaea sind verschiedene chemische, physikalische und mikrobielle Auslöser bekannt. Zu den seltenen Triggerfaktoren gehören Röntgenstrahlen. Wir beobachteten eine strahleninduzierte zirkumskripte Sklerodermie 14 Jahre nach einer Röntgentiefenbestrahlung wegen eines Mammakarzinoms. Zusätzlich bestand eine transepidermale Elimination saurer Muzine, die zunächst als Papulovesikel mit schleimiger Exsudation imponierten und klinisch den Verdacht auf ein Brustwandrezidiv des Mammakarzinoms im Sinne einer tumorbedingten superfiziellen Lymphangiektasie ergaben. Die Bestrahlung führte zu einer regionalen und gleichzeitig bestehenden chronischen Radiodermatitis, Morphaea und papulösen Muzinose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050952
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Vulvodynie (2000)
    Springer
    Der Hautarzt 51 (2000), S. 147-151 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Vulvodynie ; Klinische Subtypen ; Dermatosen der Vulva ; Differentialdiagnose ; Key words Vulvodynia ; Clinical subtypes ; Vulvar dermatoses ; Differential diagnoses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Vulvodynia is a complex syndrome of chronic vulvar pain. It is divided into several subtypes: 1. cyclic vulvovaginitis (pain occurs after coitus), 2. vulvar vestibulitis syndrome (pain mainly with intercourse), 3. dysaesthetic vulvodynia (psychosomatic; diagnosis of exclusion), 4. vulvar dermatoses (e.g. pemphigus vulgaris, contact dermatitis). Additional causes have been described in single cases. Though vulvodynia is often accompanied by psychological distress, somatic causes have to be considered in each case.
    Notes: Zusammenfassung Der Begriff Vulvodynie beschreibt chronische Schmerzzustände des äußeren weiblichen Genitales. Klinisch werden verschiedene Subtypen unterschieden: 1. Zyklische Vulvovaginitis mit postkoitalem Beschwerdemaximum und fraglicher Assoziation mit Candida albicans. 2. Vulvavestibulitis mit umschriebener Schmerzhaftigkeit des Introitus durch Entzündung der dortigen Drüsenausführungsgänge mit koitalem Beschwerdemaximum. 3. Essentielle Vulvodynie als funktionelles Beschwerdebild ohne erkennbare somatische Ursache. 4. Dermatosen der Vulva unterschiedlicher Genese, wobei Autoimmunerkrankungen (z.B. Pemphigus vulgaris) und Kontaktdermatitiden von besonderer Bedeutung sind. Zusätzlich kommen verschiedene meist kasuistisch dargestellte seltene Ursachen in Betracht. Somatoforme Störungen oder psychische Alterationen können die Differentialdiagnose einer somatischen Ursache der Vulvodynie (z.B. Kontaktdermatitis) verschleiern. Ein interdisziplinäres Vorgehen ist in jedem Fall sinnvoll.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050051095
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    Paper (German National Licenses)
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  • 4
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    Simulations of a Line W-based observing system for the Atlantic meridional overturning circulation (2013)
    Springer
    In:  Ocean Dynamics, 63 (8). pp. 865-880.
    Details
    Publication Date: 2019-09-23
    Description: In a series of observing system simulations, we test whether the Atlantic meridional overturning circulation (AMOC) can be observed based on the existing Line W deep western boundary array. We simulate a Line W array, which is extended to the surface and to the east to cover the basin to the Bermuda Rise. In the analyzed ocean circulation model ORCA025, such an extended Line W array captures the main characteristics of the western boundary current. Potential trans-basin observing systems for the AMOC are tested by combining the extended Line W array with a mid-ocean transport estimate obtained from thermal wind "measurements" and Ekman transport to the total AMOC (similarly to Hirschi et al., Geophys Res Lett 30(7):1413, 2003). First, we close Line W zonally supplementing the western boundary array with several "moorings" in the basin (Line W-32A degrees N). Second, we supplement the western boundary array with a combination of observations at Bermuda and the eastern part of the RAPID array at 26A degrees N (Line W-B-RAPID). Both, a small number of density profiles across the basin and also only sampling the eastern and western boundary, capture the variability of the AMOC at Line W-32A degrees N and Line W-B-RAPID. In the analyzed model, the AMOC variability at both Line W-32A degrees N and Line W-B-RAPID is dominated by the western boundary current variability. Away from the western boundary, the mid-ocean transport (east of Bermuda) shows no significant relation between the two Line W-based sections and 26A degrees N. Hence, a Line W-based AMOC estimate could yield an estimate of the meridional transport that is independent of the 26A degrees N RAPID estimate. The model-based observing system simulations presented here provide support for the use of Line W as a cornerstone for a trans-basin AMOC observing system.
    Type: Article , PeerReviewed , info:eu-repo/semantics/article
    Format: text
    DOI: 10.1007/s10236-013-0632-2
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    OceanRep: Article in a Scientific Journal - peer-reviewed
  • 5
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    Influence of Ocean Acidification on a Natural Winter-to-Summer Plankton Succession: First Insights from a Long-Term Mesocosm Study Draw Attention to Periods of Low Nutrient Concentrations (2016)
    PUBLIC LIBRARY SCIENCE
    In:  EPIC3PLoS ONE, PUBLIC LIBRARY SCIENCE, ISSN: 1932-6203
    Details
    Publication Date: 2016-12-13
    Description: Every year, the oceans absorb about 30% of anthropogenic carbon dioxide (CO2) leading to a re-equilibration of the marine carbonate system and decreasing seawater pH. Today, there is increasing awareness that these changes–summarized by the term ocean acidification (OA)–could differentially affect the competitive ability of marine organisms, thereby provoking a restructuring of marine ecosystems and biogeochemical element cycles. In winter 2013, we deployed ten pelagic mesocosms in the Gullmar Fjord at the Swedish west coast in order to study the effect of OA on plankton ecology and biogeochemistry under close to natural conditions. Five of the ten mesocosms were left unperturbed and served as controls (~380 μatm pCO2), whereas the others were enriched with CO2-saturated water to simulate realistic end-of-the-century carbonate chemistry conditions (~760 μatm pCO2). We ran the experiment for 113 days which allowed us to study the influence of high CO2 on an entire winter-to-summer plankton succession and to investigate the potential of some plankton organisms for evolutionary adaptation to OA in their natural environment. This paper is the first in a PLOS collection and provides a detailed overview on the experimental design, important events, and the key complexities of such a “long-term mesocosm” approach. Furthermore, we analyzed whether simulated end-of-the-century carbonate chemistry conditions could lead to a significant restructuring of the plankton community in the course of the succession. At the level of detail analyzed in this overview paper we found that CO2-induced differences in plankton community composition were non-detectable during most of the succession except for a period where a phytoplankton bloom was fueled by remineralized nutrients. These results indicate: (1) Long-term studies with pelagic ecosystems are necessary to uncover OA-sensitive stages of succession. (2) Plankton communities fueled by regenerated nutrients may be more responsive to changing carbonate chemistry than those having access to high inorganic nutrient concentrations and may deserve particular attention in future studies.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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    PAPER (OA)
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