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  • Articles  (25)
Document type
  • 1
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature medicine 11 (2005), S. 1299-1305 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Graft-versus-host disease (GVHD) is caused by alloreactive donor T cells that trigger host tissue injury. GVHD develops over weeks or months, but how this immune response is maintained over time is unknown. In mouse models of human GVHD, we identify a new subset of postmitotic CD44loCD62LhiCD8+ T ...
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Obesity and type II diabetes are closely linked metabolic syndromes that afflict 〉100 million people worldwide. Although protein tyrosine phosphatase 1B (PTP1B) has emerged as a promising target for the treatment of both syndromes, the discovery of pharmaceutically acceptable inhibitors that ...
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of elasticity 54 (1999), S. 129-140 
    ISSN: 1573-2681
    Keywords: Hill's strain ; stretch tensor ; time rate.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract Based on Hill's principal components formulae, two kinds of basis-free time rate formulae for Hill's strain tensors are proposed in this paper, which are obtained for the cases of distinct stretches, double coalescence and triple coalescence. Furthermore, relations between the coefficients in the representation for the strain tensor and its time derivative are disclosed.
    Type of Medium: Electronic Resource
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  • 4
    Publication Date: 2021-05-12
    Description: The long-term warming of the ocean is a critical indicator of both the past and present state of the climate system. It also provides insights about the changes to come, owing to the persistence of both decadal variations and secular trends, which the ocean records extremely well (Hansen et al., 2011; IPCC, 2013; Rhein et al., 2013; Trenberth et al., 2016; Abram et al., 2019). It is well established that the emission of greenhouse gasses by human activities is mainly responsible for global warming since the industrial revolution (IPCC, 2013; Abram et al., 2019). The increased concentration of heat-trapping greenhouse gases in the atmosphere has interfered with natural energy flows. Currently there is an energy imbalance in the Earth’s climate system of almost 1 W m−2 (Trenberth et al., 2014; von Schuckmann et al., 2016, 2020a; Wijffels et al., 2016; Johnson et al., 2018; Cheng et al., 2019a; von Schuckmann et al., 2020a). Over 90% of this excess heat is absorbed by the oceans, leading to an increase of ocean heat content (OHC) and sea level rise, mainly through thermal expansion and melting of ice over land. These processes provide a useful means to quantify climate change. The first global OHC time series by Levitus et al. (2000) identified a robust long-term 0−3000 m ocean warming from 1948−98. Since then, many other analyses of global and regional OHC data have been performed. Here, we provide the first analysis of recent ocean heating, incorporating 2020 measurements through 2020 into our analysis.
    Description: Published
    Description: 523–530
    Description: 4A. Oceanografia e clima
    Description: JCR Journal
    Keywords: ocean temperature ; climate change ; climate change
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 5
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    National Academy of Sciences
    In:  EPIC3PNAS, National Academy of Sciences, 111(34), pp. E3501-E3505, ISSN: 0027-8424
    Publication Date: 2016-12-09
    Description: A recent temperature reconstruction of global annual temperature shows Early Holocene warmth followed by a cooling trend through the Middle to Late Holocene [Marcott SA, et al., 2013, Science 339(6124):1198–1201]. This global cooling is puzzling because it is opposite from the expected and simulated global warming trend due to the retreating ice sheets and rising atmospheric greenhouse gases. Our critical reexamination of this contradiction between the reconstructed cooling and the simulated warming points to potentially significant biases in both the seasonality of the proxy reconstruction and the climate sensitivity of current climate models.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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  • 6
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    Wiley
    In:  EPIC3Geophysical Research Letters, Wiley, 41(17), pp. 6252-6258, ISSN: 0094-8276
    Publication Date: 2019-07-17
    Description: The transient response of the Atlantic Meridional Overturning Circulation (AMOC) to a deglacial ice-sheet retreat is studied using the Community Climate System Model version 3 (CCSM3), with a focus on orographic effects rather than meltwater discharge. It is found that the AMOC weakens significantly (41%) in response to the deglacial ice-sheet retreat. The AMOC weakening follows the decrease of the Northern Hemisphere ice-sheet volume linearly, with no evidence of abrupt thresholds. A wind-driven mechanism is proposed to explain the weakening of the AMOC: lowering the Northern Hemisphere ice sheets induces a northward shift of the westerlies, which causes a rapid eastward sea-ice transport and expanded sea-ice cover over the subpolar North Atlantic; this expanded sea ice insulates the ocean from heat loss and leads to suppressed deep convection and a weakened AMOC. A sea ice-ocean positive feedback could be further established between the AMOC decrease and sea-ice expansion.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , peerRev
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  • 7
    Publication Date: 2021-06-07
    Description: The Last Glacial Maximum (LGM, ∼ 21 000 years ago) has been a major focus for evaluating how well state-of-the-art climate models simulate climate changes as large as those expected in the future using paleoclimate reconstructions. A new generation of climate models has been used to generate LGM simulations as part of the Paleoclimate Modelling Intercomparison Project (PMIP) contribution to the Coupled Model Intercomparison Project (CMIP). Here, we provide a preliminary analysis and evaluation of the results of these LGM experiments (PMIP4, most of which are PMIP4-CMIP6) and compare them with the previous generation of simulations (PMIP3, most of which are PMIP3-CMIP5). We show that the global averages of the PMIP4 simulations span a larger range in terms of mean annual surface air temperature and mean annual precipitation compared to the PMIP3-CMIP5 simulations, with some PMIP4 simulations reaching a globally colder and drier state. However, the multi-model global cooling average is similar for the PMIP4 and PMIP3 ensembles, while the multi-model PMIP4 mean annual precipitation average is drier than the PMIP3 one. There are important differences in both atmospheric and oceanic circulations between the two sets of experiments, with the northern and southern jet streams being more poleward and the changes in the Atlantic Meridional Overturning Circulation being less pronounced in the PMIP4-CMIP6 simulations than in the PMIP3-CMIP5 simulations. Changes in simulated precipitation patterns are influenced by both temperature and circulation changes. Differences in simulated climate between individual models remain large. Therefore, although there are differences in the average behaviour across the two ensembles, the new simulation results are not fundamentally different from the PMIP3-CMIP5 results. Evaluation of large-scale climate features, such as land–sea contrast and polar amplification, confirms that the models capture these well and within the uncertainty of the paleoclimate reconstructions. Nevertheless, regional climate changes are less well simulated: the models underestimate extratropical cooling, particularly in winter, and precipitation changes. These results point to the utility of using paleoclimate simulations to understand the mechanisms of climate change and evaluate model performance.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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  • 8
    Publication Date: 2021-07-26
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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  • 9
    Publication Date: 2022-03-16
    Description: The increased concentration of greenhouse gases in the atmosphere from human activities traps heat within the climate system and increases ocean heat content (OHC). Here, we provide the first analysis of recent OHC changes through 2021 from two international groups. The world ocean, in 2021, was the hottest ever recorded by humans, and the 2021 annual OHC value is even higher than last year’s record value by 14 ± 11 ZJ (1 zetta J = 1021 J) using the IAP/CAS dataset and by 16 ± 10 ZJ using NCEI/NOAA dataset. The long-term ocean warming is larger in the Atlantic and Southern Oceans than in other regions and is mainly attributed, via climate model simulations, to an increase in anthropogenic greenhouse gas concentrations. The year-to-year variation of OHC is primarily tied to the El Niño-Southern Oscillation (ENSO). In the seven maritime domains of the Indian, Tropical Atlantic, North Atlantic, Northwest Pacific, North Pacific, Southern oceans, and the Mediterranean Sea, robust warming is observed but with distinct inter-annual to decadal variability. Four out of seven domains showed record-high heat content in 2021. The anomalous global and regional ocean warming established in this study should be incorporated into climate risk assessments, adaptation, and mitigation.
    Description: Published
    Description: 373–385
    Description: 4A. Oceanografia e clima
    Description: JCR Journal
    Keywords: ocean warming
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 10
    Publication Date: 2022-05-26
    Description: Author Posting. © The Author(s), 2014. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution. The definitive version was published in Palaeogeography, Palaeoclimatology, Palaeoecology 415 (2014): 3-13, doi:10.1016/j.palaeo.2014.05.030.
    Description: Reconstructions of surface paleoceanographic conditions of the western equatorial Atlantic and past climates of the adjacent Northeast Brazilian (the "Nordeste") continental margin were undertaken by analyzing sediments from a piston core and associated gravity and box cores recovered from 3107 meter water depth at 0° 20’ N on the equatorial Brazilian continental slope. The record is dated by radiocarbon analysis and oxygen isotopic stratigraphy of planktonic foraminifers and spans from near- modern to approximately 110 Ka. High-resolution XRF analysis provides insight into the paleoclimate history of the Nordeste during the last glacial interval. Several large-amplitude and abrupt peaks are observed in the time series of Ti/Ca and are usually accompanied by peaks of Fe/K. Together these record periods of increased precipitation and intense weathering on the adjacent continent and increased terrestrial sediment discharge from Nordeste rivers into the Atlantic. Within the limits of dating accuracy, most Ti/Ca peaks correlate with Heinrich events in the North Atlantic. This record thus corroborates, and extends back in time, the previous record of Arz et al (1998) determined on sediment cores from farther southeast along the Nordeste margin. Stable oxygen isotopic analysis and Mg/Ca paleothermometry on the near- surface-dwelling planktonic foraminiferal species Globierinoides ruber find that mean sea-surface temperature (SST) during glacial time (20 to 55 Ka, n = 97) was 23.89 ± 0.79 °C and the mean SST during the late Holocene (0 to 5 Ka, n = 14) was 26.89 ± 0.33 °C. SSTs were 0.5 to 2 °C higher and inferred sea-surface salinities were lower during most of the periods of elevated Ti/Ca, thus, as observed in previous studies, the western equatorial Atlantic was warm (at least locally) and the adjacent southern tropical continent was wet at the same time that the high-latitude North Atlantic was cold. Using the SYNTRACE-CCSM3 fully coupled climate model with transient forcing for the period 22 Ka to present, we find that decreased transport of the North Brazil Current co-occurs with reduced Atlantic meridional overturning circulation, and colder-than-normal SSTs in the North Atlantic region. These simulated conditions are invariably associated with significantly increased precipitation in the Nordeste region.
    Description: Funding for the cruise and post-cruise science was provided to PAB by NSF-OCE-0823650.
    Keywords: North Brazil Current ; Amazon margin ; Late Quaternary ; Heinrich events
    Repository Name: Woods Hole Open Access Server
    Type: Preprint
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