Description: Highlights • Temporally close-spaced double eruption within a couple of hundreds of years. • Magmas are variably tapped from zoned magma chambers during eruptions due to changing magma discharge rates and/or vent migration. • Eruptions started with a series of fallouts featuring stable eruption columns followed by fluctuating and partially collapsing eruption columns. • Eruptive volumes sum up to a total of 25.6 km3 and 40.5 km3 tephra volume, eruption column heights have been between 20–33 km. • Potential hazards from similar sized eruptions around Coatepeque Caldera are indicated even in the distal regions around San Salvador. Abstract The Coatepeque volcanic complex in El Salvador produced at least four Plinian eruptions within the last 80 kyr. The eruption of the 72 ka old Arce Tephra formed the Coatepeque Caldera and was one of the most powerful explosive eruptions in El Salvador. Hitherto it was thought that the Arce tephra had been emplaced only by one, mostly Plinian, eruptive event that ended with the deposition of a thick ignimbrite. However, our stratigraphic, geochemical, and zircon data reveal a temporally closely- spaced double eruption separated by a gap of only a couple of hundred years, and we therefore distinguish Lower and Upper Arce Tephras. Both eruptions produced in the beginning a series of fallout units generated from fluctuating eruption columns and turning wind directions. The final phase of the Upper Arce eruption produced surge deposits by several eruption column collapses before the terminal phase of catastrophic ignimbrite eruption and caldera collapse. Mapping of the individual tephra units including the occurrences of distal marine and lacustrine ash layers in the Pacific Ocean, the Guatemalan lowlands and the Caribbean Sea, result in 25.6 km3 tephra volume, areal distribution of 4 × 105 km2 and eruption column heights between 20–33 km for the Lower Arce eruption, and 40.5 km3 tephra volume, including 10 km3 for the ignimbrite, distributed across 6 × 105 km2 and eruption column heights of 23–28 km for the Upper Arce eruption. These values and the detailed eruptive sequence emphasize the great hazard potential of possible future highly explosive eruptions at Coatepeque Caldera, especially for this kind of double eruption.

Description: Venous thromboembolism (VTE) is the third most common life-threatening cardiovascular condition in the United States, with African Americans (AAs) having a 30% to 60% higher incidence compared with other ethnicities. The mechanisms underlying population differences in the risk of VTE are poorly understood. We conducted the first genome-wide association study in AAs, comprising 578 subjects, followed by replication of highly significant findings in an independent cohort of 159 AA subjects. Logistic regression was used to estimate the association between genetic variants and VTE risk. Through bioinformatics analysis of the top signals, we identified expression quantitative trait loci (eQTLs) in whole blood and investigated the messenger RNA expression differences in VTE cases and controls. We identified and replicated single-nucleotide polymorphisms on chromosome 20 (rs2144940, rs2567617, and rs1998081) that increased risk of VTE by 2.3-fold ( P 〈 6 x 10 –7 ). These risk variants were found in higher frequency among populations of African descent (〉20%) compared with other ethnic groups (〈10%). We demonstrate that SNPs on chromosome 20 are cis -eQTLs for thrombomodulin ( THBD ), and the expression of THBD is lower among VTE cases compared with controls ( P = 9.87 x 10 –6 ). We have identified novel polymorphisms associated with increased risk of VTE in AAs. These polymorphisms are predominantly found among populations of African descent and are associated with THBD gene expression. Our findings provide new molecular insight into a mechanism regulating VTE susceptibility and identify common genetic variants that increase the risk of VTE in AAs, a population disproportionately affected by this disease.