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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 69 (1991), S. 413-415 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Mathematische Zeitschrift 148 (1976), S. 107-118 
    ISSN: 1432-1823
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Numerische Mathematik 25 (1976), S. 185-200 
    ISSN: 0945-3245
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Summary For two-fold integrals, a lower bound is derived for the number of nodes in a cubature formula of degree 2s-1. There is a formula of degree 2s-1 for which the number of nodes attains this lower bound, iff a certain condition is fullfilled. By this condition, all formulas of degree 2s-1 with that minimal number of nodes can be constructed. Examples and a generalization to then-dimensional case are given.
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 284 (1992), S. 242-245 
    ISSN: 1432-069X
    Keywords: Immunogold ; Electron microscopy ; Human skin ; Actin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Normal human skin was embedded in Lowicryl K4M. Actin microfilaments were localized by applyinga postembedding immunogold technique using the monoclonal anti-actin antibody HHF35. Actin microfilaments are part of the cytoskeleton in muscle and nonmuscle cells. Together with myosin they produce contraction. The antibody labelled myofilaments in smooth muscle arrector pili cells, myoepithelial cells and pericytes. In sweat gland cells the microvilli system, a zone beneath the cytoplasma membrane correponding to the adhesion belt region, and apocrine decapitation formations showed labelling.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Applicable algebra in engineering, communication and computing 4 (1993), S. 103-145 
    ISSN: 1432-0622
    Keywords: Gröbner bases ; Polynomial ideals ; Dual bases ; Interpolation ; 0-dimensional schemes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics , Technology
    Notes: Abstract In this paper we study 0-dimensional polynomial ideals defined by a dual basis, i.e. as the set of polynomials which are in the kernel of a set of linear morphisms from the polynomial ring to the base field. For such ideals, we give polynomial complexity algorithms to compute a Gröbner basis, generalizing the Buchberger-Möller algorithm for computing a basis of an ideal vanishing at a set of points and the FGLM basis conversion algorithm. As an application to Algebraic Geometry, we show how to compute in polynomial time a minimal basis of an ideal of projective points.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Applicable algebra in engineering, communication and computing 4 (1993), S. 217-230 
    ISSN: 1432-0622
    Keywords: Algebraic variety decomposition ; Gröbner bases ; Systems of nonlinear equations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics , Technology
    Notes: Abstract This paper deals with systems ofm polynomial equations inn unknown, which have only finitely many solutions. A method is presented which decomposes the solution set into finitely many subsets, each of them given by a system of type $$f_1 \left( {x_1 } \right) = 0,f_2 \left( {x_1 ,x_2 } \right) = 0, \ldots ,f_n \left( {x_1 , \ldots ,x_n } \right) = 0$$ . The main tools for the decomposition are from ideal theory and use symbolical manipulations. For the ideal generated by the polynomials which describe the solution set, a lexicographical Gröbner basis is required. A particular element of this basis allows the decomposition of the solution set. By a recursive application of these decomposition techniques the triangular subsystems are finally obtained. The algorithm gives even for non-finite solution sets often also usable decompositions.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-2072
    Keywords: Schizophrenia ; negative symptoms ; clinical trials ; psychiatric status rating scales ; neuroleptics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract There is little agreement about the methodology of clinical trials of antipsychotic drugs in patients with negative symptoms. A literature review revealed wide variation in experimental design, rating scales and study duration. This reflects differing views as to the definition and response to treatment of negative symptoms. Some degree of standardization would improve comparability of studies and aid the development of new compounds. Patients included in such studies should have displayed negative symptoms for at least 6 months. Depressive symptoms, positive schizophrenic symptoms and extrapyramidal signs may all influence or be confused with negative symptoms and may respond to treatment; they should be at a low level at baseline and should be measured during the study period. Studies should last at least 8 weeks. Several scales are available for measuring negative symptoms and are reviewed; a global impression score should be used additionally.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 152 (1993), S. 110-114 
    ISSN: 1432-1076
    Keywords: Deuterium oxide ; Water turnover ; Fluid intake
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract For healthy children up to 15 years of age, no data exist regarding water turnover as directly measured using stable isotope techniques. Water turnover was measured in 171 healthy children (88 girls, 83 boys, age: 6 weeks–15 years) whilst living in their normal environment. Water turnover was calculated from the equilibrium of2H2O concentration reached in the urine 2–3 h after an oral test load of 2 ml2H2O/kg and the subsequent elimination rate of2H2O. Daily water turnover decreased from 160 ml/kg (3 months), 100 ml/kg (12 months), 65 ml/kg (3 years) to 40 ml/kg at 15 years of age. Fluid intake was then calculated by subtracting the estimated metabolic water production from water turnover and this data was compared with recommended values. Our calculation of spontaneous daily fluid intake for these healthy children is within the recommended range during the 1st year of life, whereas for older children the recommendations exceed the spontaneous intake by a factor of 1,2–2.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-1076
    Keywords: Phenylketonuria ; Myelination ; Magnetic resonance imaging ; 1H spectroscopy ; T2 relaxometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to further clarify the pathogenesis and clinical significance of MRI white matter abnormalities in treated hyperphenylalaninaemia (HPA), ten patients (seven type I HPA, two type II and one type III) underwent T2 relaxometry (n=8) and/or1H spectroscopy (n=7) in addition to conventional MR spin-echo imaging at 1.5 T. Two patients with severe MRI abnormalities had repeat examinations during and after a 6-to 8-month period of strict diet control. The clinical evaluation included a detailed neurological examination. In nine out of ten patients visual evoked potentials (VEP) were obtained parallel to the MR examination. MR imaging demonstrated typical symmetrical areas of prolonged T2 relaxation time predominantly in the posterior periventricular white matter in all but one of type I and II patients. There was no consistent relationship between MRI findings and time of diagnosis/initiation of therapy, IQ or visual evoked potential changes. MRI abnormalities tended to be more severe in patients with poor dietary control and high current plasma phenylalanine levels, whereas a normal MRI was found only in patients with plasma phenylalanine levels continuously below 0.36 mmol/l. There was marked regression of MRI abnormalities already after 3 months of strict diet control. T2 relaxometry showed a bi-exponential behaviour of T2 in the affected white matter, with a slow component of about 200–450 ms, indicating an increase in free (extracellular) water.1H spectroscopy revealed no signs of severe neuronal damage. We conclude, that the observed white matter changes in treated HPA probably represent reversible structural myelin changes rather than permanent demyelination.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 227 (1979), S. 301-317 
    ISSN: 1433-8491
    Keywords: Manic psychoses ; Beta blockers ; Manische Psychosen ; Beta-Blocker
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Im Rahmen einer doppelblind durchgeführten, placebokontrollierten Studie wurden sechs manische Patienten mit hohen Dosen doder d- und dl-Propranolol behandelt. Dabei wurden folgende Variablen gemessen: Propranolol-Dosis, Propranolol-Serumkonzentration, Pulsfrequenz, Blutdruck und Psychopathologie. In allen Fällen konnte eine klinische Besserung festgestellt werden, aber hohe Dosen waren erforderlich, um einen befriedigenden therapeutischen Effekt zu erreichen. Die antimanische Wirksamkeit von d-Propranolol erschien, verglichen mit der von dl-Propranolol, um etwa 50% geringer. Aus diesem Ergebnis kann geschlossen werden, daß wenigstens ein Teil der antimanischen Wirksamkeit von Beta-Blockern unabhängig ist von den beta-blockierenden Eigenschaften dieser Substanzen.
    Notes: Summary Six manic patients were treated with high doses of d-propranolol or d- and dl-propranolol in a double-blind, placebo controlled study. The following variables were measured: propranolol dosage, propranolol serum concentration, pulse frequency, blood pressure, and psychotic behavior. In all cases an improvement was noticed. High dosages were necessary to obtain sufficient effect. The antimanic property of d-propranolol was approximately 50% smaller than the antimanic property of dl-propranolol. We conclude that at least some part of the antimanic action of beta-blockers is independent from the beta-blocking property.
    Type of Medium: Electronic Resource
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