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  • 1
    Online Resource
    Online Resource
    Cham :Springer International Publishing AG,
    Keywords: Neurosciences. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (180 pages)
    Edition: 1st ed.
    ISBN: 9783319553108
    Series Statement: Intelligent Systems Reference Library ; v.126
    DDC: 006.3
    Language: English
    Note: Intro -- Preface -- Contents -- Acronyms -- 1 Introduction -- 1.1 Background -- 1.2 Spiking Neurons -- 1.2.1 Biological Background -- 1.2.2 Generations of Neuron Models -- 1.2.3 Spiking Neuron Models -- 1.3 Neural Codes -- 1.3.1 Rate Code -- 1.3.2 Temporal Code -- 1.3.3 Temporal Code Versus Rate Code -- 1.4 Cognitive Learning and Memory in the Brain -- 1.4.1 Temporal Learning -- 1.4.2 Cognitive Memory in the Brain -- 1.5 Objectives and Contributions -- 1.6 Outline of the Book -- References -- 2 Rapid Feedforward Computation by Temporal Encoding and Learning with Spiking Neurons -- 2.1 Introduction -- 2.2 The Spiking Neural Network -- 2.3 Single-Spike Temporal Coding -- 2.4 Temporal Learning Rule -- 2.4.1 The Tempotron Rule -- 2.4.2 The ReSuMe Rule -- 2.4.3 The Tempotron-Like ReSuMe Rule -- 2.5 Simulation Results -- 2.5.1 The Data Set and the Classification Problem -- 2.5.2 Encoding Images -- 2.5.3 Choosing Among Temporal Learning Rules -- 2.5.4 The Properties of Tempotron Rule -- 2.5.5 Recognition Performance -- 2.6 Discussion -- 2.6.1 Encoding Benefits from Biology -- 2.6.2 Types of Synapses -- 2.6.3 Schemes of Readout -- 2.6.4 Extension of the Network for Robust Sound Recognition -- 2.7 Conclusion -- References -- 3 A Spike-Timing Based Integrated Model for Pattern Recognition -- 3.1 Introduction -- 3.2 The Integrated Model -- 3.2.1 Neuron Model and General Structure -- 3.2.2 Latency-Phase Encoding -- 3.2.3 Supervised Spike-Timing Based Learning -- 3.3 Numerical Simulations -- 3.3.1 Network Architecture and Encoding of Grayscale Images -- 3.3.2 Learning Performance -- 3.3.3 Generalization Capability -- 3.3.4 Parameters Evaluation -- 3.3.5 Capacity of the Integrated System -- 3.4 Related Works -- 3.5 Conclusions -- References -- 4 Precise-Spike-Driven Synaptic Plasticity for Hetero Association of Spatiotemporal Spike Patterns. , 4.1 Introduction -- 4.2 Methods -- 4.2.1 Spiking Neuron Model -- 4.2.2 PSD Learning Rule -- 4.3 Results -- 4.3.1 Association of Single-Spike and Multi-spike Patterns -- 4.3.2 Generality to Different Neuron Models -- 4.3.3 Robustness to Noise -- 4.3.4 Learning Capacity -- 4.3.5 Effects of Learning Parameters -- 4.3.6 Classification of Spatiotemporal Patterns -- 4.4 Discussion and Conclusion -- References -- 5 A Spiking Neural Network System for Robust Sequence Recognition -- 5.1 Introduction -- 5.2 The Integrated Network for Sequence Recognition -- 5.2.1 Rationale of the Whole System -- 5.2.2 Neural Encoding Method -- 5.2.3 Item Recognition with the PSD Rule -- 5.2.4 The Spike Sequence Decoding Method -- 5.3 Experimental Results -- 5.3.1 Learning Performance Analysis of the PSD Rule -- 5.3.2 Item Recognition -- 5.3.3 Spike Sequence Decoding -- 5.3.4 Sequence Recognition System -- 5.4 Discussions -- 5.4.1 Temporal Learning Rules and Spiking Neurons -- 5.4.2 Spike Sequence Decoding Network -- 5.4.3 Potential Applications in Authentication -- 5.5 Conclusion -- References -- 6 Temporal Learning in Multilayer Spiking Neural Networks Through Construction of Causal Connections -- 6.1 Introduction -- 6.2 Multilayer Learning Rules -- 6.2.1 Spiking Neuron Model -- 6.2.2 Multilayer PSD Rule -- 6.2.3 Multilayer Tempotron Rule -- 6.3 Heuristic Discussion on the Multilayer Learning Rules -- 6.4 Simulation Results -- 6.4.1 Construction of Causal Connections -- 6.4.2 The XOR Benchmark -- 6.4.3 The Iris Benchmark -- 6.5 Discussion and Conclusion -- References -- 7 A Hierarchically Organized Memory Model with Temporal Population Coding -- 7.1 Introduction -- 7.2 The Hierarchical Organized Memory Model -- 7.2.1 Neuron Models and Neural Oscillations -- 7.2.2 Temporal Population Coding -- 7.2.3 The Tempotron Learning and STDP -- 7.3 Simulation Results. , 7.3.1 Auto-Associative Memory -- 7.3.2 Episodic Memory -- 7.4 Discussion -- 7.4.1 Information Flow and Emergence of Neural Cliques -- 7.4.2 Storage, Recall and Organization of Memory -- 7.4.3 Temporal Compression and Information Binding -- 7.4.4 Related Works -- 7.5 Conclusion -- References -- 8 Spiking Neuron Based Cognitive Memory Model -- 8.1 Introduction -- 8.2 SRM-Based CA3 Model -- 8.2.1 Spike Response Model -- 8.2.2 SRM-Based Pyramidal Cell -- 8.2.3 SRM-Based Interneuron -- 8.3 Convergence of Synaptic Weight -- 8.4 Maximum Synaptic Weight to Prevent Early Activation -- 8.5 Pattern Completion of Auto-Associative Memory -- 8.6 Discussion -- 8.7 Conclusion -- References.
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  • 2
    Publication Date: 2022-05-25
    Description: © The Author(s), 2018. This is the author's version of the work and is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Current Opinion in Environmental Sustainability 33 (2018): 104-113, doi:10.1016/j.cosust.2018.04.003.
    Description: Increased natural and anthropogenic stresses have threatened the Earth’s ability to meet growing human demands of food, energy and water (FEW) in a sustainable way. Although much progress has been made in the provision of individual component of FEW, it remains unknown whether there is an optimized strategy to balance the FEW nexus as a whole, reduce air and water pollution, and mitigate climate change on national and global scales. Increasing FEW conflicts in the agroecosystems make it an urgent need to improve our understanding and quantification of how to balance resource investment and enhance resource use efficiencies in the FEW nexus. Therefore, we propose an integrated modeling system of the FEW nexus by coupling an ecosystem model, an economic model, and a regional climate model, aiming to mimic the interactions and feedbacks within the ecosystem-human-climate systems. The trade-offs between FEW benefit and economic cost in excess resource usage, environmental degradation, and climate consequences will be quantitatively assessed, which will serve as sustainability indicators for agricultural systems (including crop production, livestock and aquaculture). We anticipate that the development and implementation of such an integrated modeling platform across world’s regions could build capabilities in understanding the agriculture-centered FEW nexus and guiding policy and land management decision making for a sustainable future.
    Description: This study has been supported by National Key R & D Program of China (no. 2017YFA0604702), CAS STS Program (KFJ-STS-ZDTP-010-05), SKLURE Grant (SKLURE2017-1-6), National Science Foundation (1210360, 1243232), NOAA Grants (NA16NOS4780207, NA16NOS4780204), and AU-OUC Joint Center Program.
    Description: 2020-05-28
    Repository Name: Woods Hole Open Access Server
    Type: Preprint
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  • 3
    Publication Date: 2015-01-30
    Description: Cell loss due to apoptosis induced by oxidative stress is a major hurdle for endothelial progenitor cells (EPCs)-based therapy. Sirtuin 1 (SIRT1) plays important roles in many pathophysiological processes by deacetylating various substrates, including forkhead transcription factor (FOXO). However, after deacetylation, the fate of FOXO protein remains to be explored. In the present study, we investigated whether SIRT1 exerted a protective effect on hydrogen peroxide (H 2 O 2 )-induced EPCs apoptosis and, if so, what the underlying mechanism might be. EPCs were isolated and obtained from human umbilical cord blood by density gradient centrifugation and identified by morphology, tube formation ability, cell surface markers and the ability to take up acetylated low density lipoprotein (Dil-Ac-LDL) and bind ulex europaeus agglutinin 1 (FITC-UEA-1). Immunofluorescence showed that SIRT1 localized in the nucleus of EPCs in the presence or absence of H 2 O 2 . SIRT1 protein level in EPCs was increased by the treatment with H 2 O 2 for 24 h. Incubation of EPCs with H 2 O 2 dose dependently induced EPCs apoptosis. SIRT1 overexpression reduced the rate of EPCs apoptosis induced by H 2 O 2 , while SIRT1 downregulation and EX527, a specific SIRT1 inhibitor, exerted the opposite effect. SIRT1 overexpression decreased the total FOXO3a protein expression, whereas SIRT1 downregulation and EX527 increased the amount of FOXO3a protein. SIRT1 reduced FOXO3a transcriptional activity according to Bim expression. Co-immunoprecipitation (Co-IP) assay showed that SIRT1 could bind to FOXO3a, reduce its acetylation level and increase its ubiquitination level. To sum up, our work demonstrated that SIRT1 had a pivotally protective role in the regulation of EPCs apoptosis induced by H 2 O 2 and that SIRT1 protected against apoptosis by inhibiting FOXO3a via FOXO3a ubiquitination and subsequent degradation. This article is protected by copyright. All rights reserved
    Electronic ISSN: 1097-4652
    Topics: Biology , Medicine
    Published by Wiley-Blackwell
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  • 4
    Publication Date: 2015-09-19
    Description: Energy & Fuels DOI: 10.1021/acs.energyfuels.5b01507
    Print ISSN: 0887-0624
    Electronic ISSN: 1520-5029
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering , Process Engineering, Biotechnology, Nutrition Technology
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  • 5
    Publication Date: 2015-11-20
    Description: Background: Hook plate (HP) is popularly used for acute and severely displaced acromioclavicular (AC) dislocations. However, subacromial impingement and acromion osteolysis induced by transarticular fixation are notorious. The current case–control study was to compare transarticular fixation by HP to coracoclavicular (CC) stabilization by single multistrand titanium cable (MSTC). Methods: Between January 2006 and August 2009, 24 patients with acute AC dislocations were surgically treated by open reduction and transarticular fixation with HP. These patients were matched to a series of 24 patients, who were managed by CC stabilization with MSTC in the same period. All AC dislocations were graded as Rockwood type V. Implant was removed 8 -- 12 months after the primary operation in all patients, and 12 months at least were needed to assess the maintenance of AC joint. Functional results were evaluated before implant removal as well as in the last follow-up based on Constant-Murley criteria. Results: There were no differences of demographic data including age, dominant gender and side, injury-to-surgery interval, operation time and follow-up period. In terms of functionality, Constant score was 95.8 ± 4.1 in MSTC group, while 76.7 ± 8.0 in HP group before implant removal (P 
    Electronic ISSN: 1471-2474
    Topics: Medicine
    Published by BioMed Central
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  • 6
    Publication Date: 2016-05-20
    Description: Nature Immunology 17, 695 (2016). doi:10.1038/ni.3456 Authors: Shaojun Xing, Fengyin Li, Zhouhao Zeng, Yunjie Zhao, Shuyang Yu, Qiang Shan, Yalan Li, Farrah C Phillips, Peterson K Maina, Hank H Qi, Chengyu Liu, Jun Zhu, R Marshall Pope, Catherine A Musselman, Chen Zeng, Weiqun Peng & Hai-Hui Xue
    Print ISSN: 1529-2908
    Electronic ISSN: 1529-2916
    Topics: Biology , Medicine
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  • 7
    Publication Date: 2015-06-21
    Description: Background: Burden of non-communicable diseases (NCDs) is increasing rapidly in most of the developing countries including China, even in rural areas. Dearth of representative data called for an investigation to estimate the burden and identify the correlates of NCDs in rural China. Methods: A cross-sectional study was conducted involving a representative sample of 6003 consenting randomly selected rural residents aged 15 years or more, from 36 villages of Shijiazhuang in Hebei province of China between July 2010 and June 2011. Information on demographics and behavior were collected, body mass index (BMI) and blood pressure were measured and blood samples were tested to diagnose diabetes and hyperlipidemia. Results: Majority participants were aged 
    Electronic ISSN: 1471-2458
    Topics: Medicine
    Published by BioMed Central
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  • 8
    Publication Date: 2016-06-10
    Description: Atmospheric wet nitrogen (N) and phosphorus (P) depositions are important sources of bioavailable N and P, and the input of N and P and their ratios significantly influence nutrient availability and balance in terrestrial as well as aquatic ecosystems. Here we monitored atmospheric P depositions by measuring monthly dissolved P concentration in rainfall at 41 field stations in China. Average deposition fluxes of N and P were 13.69 ± 8.69 kg N ha –1 a –1 (our previous study) and 0.21 ± 0.17 kg P ha –1 a –1 , respectively. Central and southern China had higher N and P deposition rates than northwest China, northeast China, Inner Mongolia, or Qinghai-Tibet. Atmospheric N and P depositions showed strong seasonal patterns and were dependent upon seasonal precipitation. Fertilizer and energy consumption were significantly correlated with N deposition but less correlated with P deposition. The N:P ratios of atmospheric wet deposition (with the average of 77 ± 40, by mass), were negatively correlated with current soil N:P ratios in different ecological regions, suggesting that the imbalanced atmospheric N and P deposition will alter nutrient availability and strengthen P limitation, which may further influence the structure and function of terrestrial ecosystems. The findings provide the assessments of both wet N and P deposition and their N:P ratio across China and indicate potential for strong impacts of atmospheric deposition on broad range of terrestrial ecosystems.
    Print ISSN: 0148-0227
    Topics: Biology , Geosciences
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  • 9
    Publication Date: 2016-09-15
    Description: Endothelial progenitor cells (EPCs) play important roles in the regeneration of the vascular endothelial cells (ECs). Platelet-derived growth factor receptor (PDGFR)-β is known to contribute to proliferation, ...
    Electronic ISSN: 1471-2261
    Topics: Medicine
    Published by BioMed Central
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  • 10
    Publication Date: 2017-08-15
    Description: Author(s): Qiu-shi Chen, Aurelio Patelli, Hugues Chaté, Yu-qiang Ma, and Xia-qing Shi We show that fore-aft asymmetry, a generic feature of living organisms and some active matter systems, can have a strong influence on the collective properties of even the simplest flocking models. Specifically, an arbitrarily weak asymmetry favoring front neighbors changes qualitatively the phase d... [Phys. Rev. E 96, 020601(R)] Published Mon Aug 14, 2017
    Keywords: Colloids, Complex Fluids, and Active Matter
    Print ISSN: 1539-3755
    Electronic ISSN: 1550-2376
    Topics: Physics
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