GLORIA

GEOMAR Library Ocean Research Information Access

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Milton :Jenny Stanford Publishing,
    Keywords: Electronic books.
    Description / Table of Contents: This book focuses on the current state of the art of polymer-based capsules. It discusses the fundamental knowledge of the formations and formulations and the properties and performances of typical polymers capsules, together with their applications.
    Type of Medium: Online Resource
    Pages: 1 online resource (419 pages)
    Edition: 1st ed.
    ISBN: 9780429767883
    Language: English
    Note: Cover -- Half Title -- Title Page -- Copyright Page -- Contents -- Preface -- 1. Redox-Responsive Nanocarriers: A Promising Drug Delivery Platform -- 1.1 Introduction -- 1.2 Redox-Responsive Polymeric Micelles -- 1.3 Redox-Responsive Liposomes -- 1.4 Redox-Responsive Polymersomes -- 1.5 Redox-Responsive Nanogels -- 1.6 Redox-Responsive Nanospheres -- 1.7 Redox-Responsive Nanocapsules -- 1.8 Conclusions -- 2. Smart Polymers-Functionalized Carbon Nanotubes Delivery Systems -- 2.1 Introduction -- 2.2 Polymers-Functionalized Carbon Nanotubes for Drugs Delivery -- 2.2.1 Paclitaxel -- 2.2.2 Doxorubicin -- 2.2.3 Platinum Metallodrugs -- 2.3 Polymers-Functionalized Carbon Nanotubes for Gene Delivery -- 2.4 Polymers-Functionalized Carbon Nanotubes for Protein Delivery -- 2.5 Summary and Future Perspectives -- 3. Smart Polymer Capsules -- 3.1 Introduction -- 3.2 Preparation -- 3.2.1 The Method of the Self-Assembly Approaches of Amphiphilic Block Copolymers -- 3.2.1.1 Film dispersion technique -- 3.2.1.2 Solvent-switching technique -- 3.2.1.3 Polymerization-induced self-assembly -- 3.2.2 Self-Assembly Approaches of Homopolymers -- 3.2.3 Self-Assembly Approaches of Hyperbranched Polymers -- 3.2.4 Self-Assembly Approaches of Graft Copolymers -- 3.2.5 Self-Assembly Approaches of Proteins -- 3.2.6 Dendrimers -- 3.2.7 Layer-by-Layer Assembly Approach -- 3.2.8 Surface/Interfacial Polymerization Approaches -- 3.2.8.1 NMRP techniques -- 3.2.8.2 ATRP techniques -- 3.2.8.3 RAFT techniques -- 3.2.8.4 Precipitation polymerization -- 3.2.8.5 Photopolymerization -- 3.2.9 Single-Step Adsorption Approaches -- 3.2.10 Polymerization and Self-Assembly Approaches in Nanodroplet -- 3.3 Application -- 3.3.1 Drug Delivery -- 3.3.1.1 Physical stimuli for drug delivery -- 3.3.1.2 Chemical stimuli for drug delivery -- 3.3.1.3 Biological stimuli for drug delivery. , 3.3.2 Gene Delivery -- 3.3.3 Biomimetic Microreactors -- 3.3.3.1 Enzyme catalysis -- 3.3.3.2 Polymerization -- 3.3.3.3 Nanoparticles synthesis -- 3.3.3.4 Artificial organelles -- 3.3.4 Sensing -- 3.4 Conclusion -- 4. On the Use of Complex Coacervates for Encapsulation -- 4.1 Introduction -- 4.2 Coacervation -- 4.2.1 Conditions for Complex Coacervation -- 4.2.1.1 Polyelectrolytes -- 4.2.1.2 Ions -- 4.2.1.3 Temperature -- 4.2.1.4 Foreign molecules -- 4.2.2 Properties of Complex Coacervate Phase -- 4.2.2.1 Response to changes in external conditions -- 4.2.2.2 Wetting -- 4.2.2.3 Rheological properties -- 4.3 Process of Encapsulation -- 4.3.1 Emulsification -- 4.3.2 Loading -- 4.3.3 Crosslinking -- 4.3.4 Separation and Further Processing -- 4.4 Application of Complex Coacervates for Encapsulation -- 4.5 Concluding Remarks -- 5. Improving Drug Biological Effects by Encapsulation into Polymeric Nanocapsules -- 5.1 Introduction -- 5.2 Nanostructures -- 5.2.1 Nanoemulsion -- 5.2.2 Nanospheres -- 5.2.3 Nanotubes -- 5.2.4 Nanogels -- 5.2.5 Dendrimers -- 5.2.6 Nanocapsules -- 5.3 Nanocapsule and Its Advantages over Other Nanostructures -- 5.3.1 Nanocapsules -- 5.3.1.1 Efficiency parameters of nanocapsules -- 5.3.1.2 Fabrication techniques -- 5.4 Benefits of Polymeric Nanocapsules -- 5.4.1 Increased Drug Stability Against Chemical- and Photodegradation -- 5.4.2 Increased Interaction with Cells and Tissues and Drug Targeting -- 5.4.2.1 High Specific Surface Area to Volume Ratio -- 5.4.2.2 Polymeric Shell -- 5.4.2.3 Surface Modifications -- 5.4.2.4 Representative Examples of Polymeric Nanocapsules with Enhanced Interaction with Cells and Tissues -- 5.5 Other Ways to Enhance Efficiency of Polymeric Nanocapsules -- 5.6 Evaluation Tests on Efficiency of Polymeric Nanocapsules -- 5.6.1 In Vitro Research Test of Polymeric Nanocapsules. , 5.6.1.1 Antioxidative Effects of Drugs -- 5.6.1.2 Anti-inflammatory Effects of Drugs -- 5.6.1.3 Anti-proliferative Effects of Drugs -- 5.6.1.4 Anti-microbial Effects -- 5.6.1.5 Photodynamic Therapy -- 5.6.2 In Vivo Research Test of Polymeric Nanocapsules -- 5.6.2.1 Anti-proliferative Effects of Drugs -- 5.6.2.2 Surface Active Targeting Effects of Drugs -- 5.6.2.3 Photodynamic Therapy -- 5.6.2.4 Medical Applications of Drug Delivery -- 5.6.2.5 Efficacy of Lipid-Core Nanocapsules -- 5.6.2.6 Polymeric Nanocapsules Efficiency -- 5.7 Safety Concerns Over Polymeric Nanocapsules -- 5.7.1 In Vitro Tests -- 5.7.2 In Vivo Tests -- 5.8 Conclusion -- 6. Drug and Protein Encapsulation by Emulsification: Technology Enhancement Using Foam Formulations -- 6.1 Introduction -- 6.1.1 Particle Parameters -- 6.2 Double Emulsification-Based Techniques -- 6.2.1 Water in Oil in Water Emulsification (W/O/W) -- 6.2.2 Water in Oil in Oil Emulsification (W/O/O) -- 6.2.3 Solid in Oil in Water (S/O/W) or Solid in Oil in Oil (S/O/O) Emulsification -- 6.3 Supercritical Carbon Dioxide-Based Techniques -- 6.3.1 Particles from Gas Saturated Solutions (PGSS) -- 6.3.2 Rapid Expansion from Saturated Solutions (RESS) -- 6.3.3 Supercritical Anti-solvent (SAS) -- 6.4 Conclusion -- 7. Drug Delivery Vehicles with Improved Encapsulation Efficiency: Taking Advantage of Specific Drug-Carrier Interactions -- 7.1 Introduction -- 7.1.1 Drug Delivery Mechanism -- 7.2 Commonly Used Anticancer Drug: Doxorubicin -- 7.3 Types of Carriers -- 7.3.1 Dendrimers -- 7.3.1.1 Properties of dendrimers -- 7.3.1.2 Dendrimer-drug interactions -- 7.3.2 Solid Lipid Nanoparticles -- 7.3.2.1 Factors affecting loading capacity (EE) of lipids -- 7.3.2.2 Specific SLN interaction with DOX -- 7.3.2.3 Doxorubicin-docosahexaenoic acid (DHA) interactions -- 7.3.2.4 Doxorubicin-alpha-tocopherol succinate (TS). , 7.3.3 Polymeric Micelles -- 7.3.3.1 Formation of micelle and encapsulation interactions -- 7.3.3.2 Enhancing EE via π-π stacking interactions -- 7.3.3.3 Hydrogen bonding interactions and crystallinity of PCL-DOX drug delivery systems -- 7.3.4 Liposomes -- 7.3.4.1 Effect of composition on EE of hydrophilic drugs -- 7.3.4.2 Effect of charge -- 7.4 Conclusion -- 8. Biodegradable Multilayer Capsules for Functional Foods Applications -- 8.1 Introduction -- 8.2 Polysaccharides-Based Polyelectrolyte Multilayers -- 8.3 Proteins or Poly(Amino Acid)s-Based Multilayers -- 8.4 Composite Multilayers -- 8.5 Conclusion -- 9. Essential Oils: From Extraction to Encapsulation -- 9.1 Introduction -- 9.1.1 Structure of Oil-Secreting Plants -- 9.1.2 Chemical Composition and Structure of Essential Oils -- 9.1.2.1 Terpenes -- 9.1.2.2 Terpenoids -- 9.1.3 Properties and Applications of Essential Oils -- 9.2 Extraction Methods -- 9.2.1 Hydrodistillation -- 9.2.1.1 Turbo-distillation -- 9.2.2 Organic Solvent Extraction -- 9.2.3 Cold Pressing -- 9.2.4 Innovations in Essential Oils Extraction -- 9.2.4.1 Supercriticalfluidextraction (SCFE) -- 9.2.4.2 Subcritical extraction liquids -- 9.2.4.3 Extraction with subcritical carbon dioxide -- 9.2.4.4 Ultrasound-assisted extraction (UAE) -- 9.2.4.5 Microwave-assisted extraction (MAE) -- 9.2.4.6 Solvent-free microwave extraction (SFME) -- 9.2.4.7 Microwave hydrodiffusion and gravity (MHG) -- 9.2.4.8 Microwave steam distillation (MSD) and microwave steam diffusion (MSDf) -- 9.3 Methods of Encapsulation -- 9.3.1 Encapsulation in Polymeric Particles -- 9.3.1.1 Nanoprecipitation -- 9.3.1.2 Coacervation -- 9.3.1.3 Spray drying -- 9.3.1.4 Rapid expansion of supercritical solutions (RESS) -- 9.3.2 Encapsulation in Liposomes -- 9.3.2.1 Thin film hydration -- 9.3.2.2 Reverse phase evaporation -- 9.3.2.3 Supercritical fluid technology. , 9.4 Encapsulation in Solid Lipid Nanoparticles -- 9.5 Conclusion -- 10. Semipermeable Polymeric Envelopes for Living Cells: Biomedical Applications -- 10.1 Introduction -- 10.2 Properties of Semipermeable Envelopes -- 10.2.1 Permeation Selectivity -- 10.2.2 Biocompatibility and Biostability -- 10.2.3 Mechanical Stability -- 10.3 Types of Semipermeable Envelopes -- 10.3.1 Macro-isolation Systems -- 10.3.1.1 Intravascular devices -- 10.3.1.2 Extravascular devices -- 10.3.2 Micro-isolation Systems -- 10.4 Fabrication Methods -- 10.4.1 Conformal Coating -- 10.4.2 Layer-by-Layer Technique -- 10.4.3 EMC Formation -- 10.4.4 Thermoreversible Gelation -- 10.4.5 Interfacial Polymerization -- 10.4.6 In Situ Polymerization -- 10.4.7 Interfacial Precipitation -- 10.4.8 Coacervation -- 10.4.9 Suspension Crosslinking -- 10.4.10 Coloidosomes -- 10.4.11 Incorporation of Porins -- 10.5 Polymers for Cell Encapsulation -- 10.6 Applications -- 10.6.1 Mammal Cells -- 10.6.1.1 Cell therapy -- 10.6.1.2 Cell transplantation -- 10.6.1.3 In vivo gene therapy by viral vectors -- 10.6.1.4 Stem cell therapy -- 10.6.1.5 Assisted reproduction technologies -- 10.6.1.6 Biosensors -- 10.6.1.7 Advanced tissue engineering -- 10.6.1.8 Minimizing of cell injuries upon cryopreservation -- 10.6.1.9 Other bioapplications -- 10.6.2 Bacteria -- 10.6.2.1 Probiotics -- 10.6.2.2 Bioreactor for delivery of therapeutic products -- 10.7 Conclusion -- 11. Bacteriophage Encapsulation: Trends and Potential Applications -- 11.1 Introduction -- 11.2 Motivations and Potential Applications -- 11.2.1 Food Preservation Technology -- 11.2.2 Healthcare -- 11.3 Biomaterials Involved in Encapsulation -- 11.3.1 Encapsulation Techniques -- 11.3.2 Emulsification -- 11.3.3 Extrusion -- 11.3.4 Spraydrying -- 11.3.5 Electrospun Nanofibers -- 11.4 Conclusion -- Index.
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 2
    Publication Date: 2020-07-08
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 3
    Publication Date: 2022-01-31
    Description: We present Nemo-Nordic, a Baltic and North Sea model based on the NEMO ocean engine. Surrounded by highly industrialized countries, the Baltic and North seas and their assets associated with shipping, fishing and tourism are vulnerable to anthropogenic pressure and climate change. Ocean models providing reliable forecasts and enabling climatic studies are important tools for the shipping infrastructure and to get a better understanding of the effects of climate change on the marine ecosystems. Nemo-Nordic is intended to be a tool for both short-term and long-term simulations and to be used for ocean forecasting as well as process and climatic studies. Here, the scientific and technical choices within Nemo-Nordic are introduced, and the reasons behind the design of the model and its domain and the inclusion of the two seas are explained. The model's ability to represent barotropic and baroclinic dynamics, as well as the vertical structure of the water column, is presented. Biases are shown and discussed. The short-term capabilities of the model are presented, especially its capabilities to represent sea level on an hourly timescale with a high degree of accuracy. We also show that the model can represent longer timescales, with a focus on the major Baltic inflows and the variability in deep-water salinity in the Baltic Sea.
    Type: Article , PeerReviewed
    Format: text
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 4
    Publication Date: 2015-03-29
    Description: Background: Our previous study suggested that the recurrent CHEK2 H371Y mutation is a novel pathogenic mutation that confers an increased risk of breast cancer. The purpose of this study was to investigate whether breast cancer patients with CHEK2 H371Y mutation were more likely to respond to neoadjuvant chemotherapy. Methods: We screened a cohort of 2334 Chinese women with operable primary breast cancer who received a neoadjuvant chemotherapy regimen for CHEK2 H371Y germline mutations. Pathologic complete response (pCR) was defined as the absence of tumor cells in the breast after the completion of neoadjuvant chemotherapy. Results: Thirty-nine patients (1.7%) with CHEK2 H371Y germline mutation were identified in this cohort of 2334 patients. CHEK2 H371Y mutation carriers had a significantly higher pCR rate than non-carriers (33.3% versus 19.5%, P = 0.031) in the entire study population, and CHEK2 H371Y mutation-positive status remained an independent favorable predictor of pCR in a multivariate analysis (odds ratio [OR] = 3.01; 95% confidence interval [CI]: 1.34- 6.78, P = 0.008). CHEK2 H371Y carriers had a slightly worse distant recurrence-free survival than non-carriers (adjusted hazard ratio [HR] =1.24, 95% CI: 0.59-2.63). Conclusions: CHEK2 H371Y mutation carriers are more likely to respond to neoadjuvant chemotherapy than are non-carriers.
    Electronic ISSN: 1471-2407
    Topics: Medicine
    Published by BioMed Central
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 5
    Publication Date: 2015-03-03
    Description: Catheter-related infection makes up a large part of hospital infection and contributes 80% to all nosocomial urological infection, costing hundreds of millions dollar per year for treatment. Biodegradable hydrophilic material incorporating antibiotic substance is a promising way to prevent catheter-related infection. And antimicrobial peptide seems an optimal drug for its desirable antibiotic effect. In the current research, we produced a new kind of antibiotic material by incorporating antimicrobial peptide Bmap-28 with polyurethane PEGU25 and tested its effect on Proteus mirabilis in vitro. Compared with the control group, PEGU25 membrane incorporating Bmap-28 had a significant lower bacteria load after co-cultured with the Proteus mirabilis. And its antibiotic effect could be observed throughout the whole 7-day test. Also the Bmap-28 membrane could delay catheter obstruction caused by encrustation. Our findings reveal that PEGU25 incorporating Bmap-28 can well inhibit bacterial biofilm formation of common pathogens for catheter-related urinary tract infection in vitro, which makes it a promising antibiotic material for medical tubes for urology. Scientific Reports 5 doi: 10.1038/srep08634
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 6
    Publication Date: 2015-03-31
    Description: Herein, we present a feasible, general protocol for quantum communication within a network via generalized remote preparation of an arbitrary m-qubit entangled state designed with genuine tripartite Greenberger–Horne–Zeilinger-type entangled resources. During the implementations, we construct novel collective unitary operations; these operations are tasked with performing the necessary phase transfers during remote state preparations. We have distilled our implementation methods into a five-step procedure, which can be used to faithfully recover the desired state during transfer. Compared to previous existing schemes, our methodology features a greatly increased success probability. After the consumption of auxiliary qubits and the performance of collective unitary operations, the probability of successful state transfer is increased four-fold and eight-fold for arbitrary two- and three-qubit entanglements when compared to other methods within the literature, respectively. We conclude this paper with a discussion of the presented scheme for state preparation, including: success probabilities, reducibility and generalizability.
    Electronic ISSN: 1099-4300
    Topics: Chemistry and Pharmacology , Physics
    Published by MDPI Publishing
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 7
    Publication Date: 2015-03-23
    Description: Background: Polyunsaturated fatty acids (PUFAs) are necessary for the body's metabolism, growth and development. Although PUFAs play an important role in the regulation of reproduction, their role in testis development in the rooster is unknown. The present study was conducted to investigate the effects of omega-3/omega-6 (n-3/n-6, PUFAs) ratios on reproductive performance in young breeder roosters. Plasma levels of reproductive hormones, testis development, and reproductive hormone receptor and StAR mRNA expression were also assessed. Results: Although PUFAs (n-3/n-6: 1/4.15) had no significant effect on the testis index (P 〉 0.05), the spermatogonial development and germ cell layers were increased. Moreover, serum levels of hormones (GnRH, FSH, LH and T) on day 35 were also significantly increased by PUFAs (n-3/n-6: 1/4.15). To investigate whether PUFAs regulate the expression of hormone receptors and StAR, real time-PCR was used to measure GnRHR, FSHR, LHR and StAR mRNA levels. PUFAs significantly increased the mRNA levels of all of these genes. Conclusions: These results indicate that PUFAs enhance the reproductive performance of young roosters by increasing hormone secretion and function, the latter by up-regulating receptor expression. These findings provide a sound basis for a balanced n-3/n-6 PUFA ratio being beneficial to young rooster reproduction.
    Electronic ISSN: 1746-6148
    Topics: Medicine
    Published by BioMed Central
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 8
    Publication Date: 2015-07-21
    Description: Author(s): Xiaohui Wang, Tingting Liu, Ye Xiong, and Peiqing Tong The spontaneous parity-time ( PT ) symmetry breaking is discussed in non-Hermitian PT -symmetric Kitaev and extended Kitaev models whose Hermiticity is broken by the presence of two conjugated imaginary potentials ± i γ at two end sites. In the case of the non-Hermitian Kitaev model, a spontaneous PT -sym… [Phys. Rev. A 92, 012116] Published Mon Jul 20, 2015
    Keywords: Fundamental concepts
    Print ISSN: 1050-2947
    Electronic ISSN: 1094-1622
    Topics: Physics
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 9
    Publication Date: 2016-06-14
    Description: Author(s): Bohdan Senyuk, Qingkun Liu, Ye Yuan, and Ivan I. Smalyukh Nematic colloids exhibit a large diversity of topological defects and structures induced by colloidal particles in the orientationally ordered liquid crystal host fluids. These defects and field configurations define elastic interactions and medium-mediated self-assembly, as well as serve as model s… [Phys. Rev. E 93, 062704] Published Mon Jun 13, 2016
    Keywords: Liquid Crystals
    Print ISSN: 1539-3755
    Electronic ISSN: 1550-2376
    Topics: Physics
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 10
    Publication Date: 2016-07-21
    Description: Background: although alcohol abuse is known to increase serum uric acid, the relation between moderate drinking and uric acid have remained poorly understood. We performed this study to evaluate whether different alcohol consumption level has different effects on the risk of hyperuricemia based on a rural general population. Method: multi-stage cluster sampling method was used to select a representative sample of individuals aged 35 years or older. Participants were asked to provide information about their alcohol consumption. Data regarding the demographic and lifestyle characteristics and the blood biochemical indexes of these participants were collected by well-trained personnel. Results: in total, 11,039 participants aged 35 years or older were included (4997 men and 6042 women). The prevalence of hyperuricemia in the different male alcohol consumption groups was 11.9% in non-drinkers, 12.6% in moderate drinkers, and 16.3% in heavy drinkers (p 〈 0.001). In females, the rates were 6.3% in non-drinkers, 8.1% in moderate drinkers, and 6.6% for heavy drinkers (p = 0.818). In males, multivariate logistic regression analyses shows heavy drinkers had an approximately 1.7-fold higher risk of hyperuricemia (OR: 1.657, 95% CI: 1.368 to 2.007, p 〈 0.001) than non-drinkers; moderate drinkers did not experience a significant increase in risk (OR: 1.232, 95% CI: 0.951 to 1.596, p = 0.114)). Multivariate logistic regression analyses of females showed that, compared with non-drinkers, neither moderate nor heavy drinkers had a significantly increased risk of hyperuricemia (OR: 1.565, 95% CI: 0.521 to 4.695, p = 0.425 for heavy drinkers; OR: 0.897, 95% CI: 0.117 to 6.855, p = 0.916 for moderate drinkers). Conclusions: heavy alcohol consumption increased the risk of hyperuricemia for males but not for females. Among both males and females, moderate alcohol consumption did not increase the risk of hyperuricemia.
    Print ISSN: 1661-7827
    Electronic ISSN: 1660-4601
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Published by MDPI Publishing
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...