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  • 1
    Publication Date: 2022-05-26
    Description: Author Posting. © The Author(s), 2015. This is the author's version of the work. It is posted here by permission of Nature Publishing Group for personal use, not for redistribution. The definitive version was published in Nature 531 (2016): 225-228, doi:10.1038/nature16946.
    Description: The terrestrial biosphere can release or absorb the greenhouse gases, carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O) and therefore plays an important role in regulating atmospheric composition and climate1. Anthropogenic activities such as land use change, agricultural and waste management have altered terrestrial biogenic greenhouse gas fluxes and the resulting increases in methane and nitrous oxide emissions in particular can contribute to climate warming2,3. The terrestrial biogenic fluxes of individual greenhouse gases have been studied extensively4-6, but the net biogenic greenhouse gas balance as a result of anthropogenic activities and its effect on the climate system remains uncertain. Here we use bottom-up (BU: e.g., inventory, statistical extrapolation of local flux measurements, process-based modeling) and top-down (TD: atmospheric inversions) approaches to quantify the global net biogenic greenhouse gas balance between 1981-2010 as a result of anthropogenic activities and its effect on the climate system. We find that the cumulative warming capacity of concurrent biogenic CH4 and N2O emissions is about a factor of 2 larger than the cooling effect resulting from the global land CO2 uptake in the 2000s. This results in a net positive cumulative impact of the three GHGs on the planetary energy budget, with a best estimate of 3.9±3.8 Pg CO2 eq/yr (TD) and 5.4±4.8 Pg CO2 eq/yr (BU) based on the GWP 100 metric (global warming potential on a 100-year time horizon). Our findings suggest that a reduction in agricultural CH4 and N2O emissions in particular in Southern Asia may help mitigate climate change.
    Description: This research has been supported partially by National Aeronautics and 255 Space Administration (NASA) Grants (NNX08AL73G, NNX14AO73G, NNX10AU06G, NNX11AD47G, NNG04GM39C), National Science Foundation (NSF) Grants (CNH1210360; AGS 1243232; AGS-1243220). JGC was supported by the Australian Climate Change Science Program. ES was supported by NOAA Climate Program Office (award # NA13OAR4310059). CRS was supported by NASA Grants (#NNX12AP74G, #NNX10AG01A, and #NNX11AO08A). KRG was supported by NSF CAREER (AGS-0846358). RGP was supported by NASA Upper Atmosphere Research Program AGAGE Grant (NNX11AF17G to MIT).
    Description: 2016-09-09
    Repository Name: Woods Hole Open Access Server
    Type: Preprint
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  • 2
    Publication Date: 2016-10-09
    Description: A hollow fiber temperature sensor filled with graphene-Ag composite nanowire and liquid is presented and numerically characterized. The coupling properties and sensing performances are analyzed by finite element method (FEM) using both wavelength and amplitude interrogations. Due to the asymmetrical surface plasmon resonance sensing (SPR) region, the designed sensor exhibits strong birefringence, supporting two separate resonance peaks in orthogonal polarizations. Results show that x-polarized resonance peak can provide much better signal to noise ratio (SNR), wavelength and amplitude sensitivities than y-polarized, which is more suitable for tempertature detecting. The graphene-Ag composite nanowire filled into the hollow fiber core can not only solve the oxidation problem but also avoid the metal coating. A wide temperature range from 22 ∘ C to 47 ∘ C with steps of 5 ∘ C is calculated and the temperature sensitivities we obtained are 9.44 nm/ ∘ C for x-polarized and 5.33 nm/ ∘ C for y-polarized, much higher than other sensors of the same type.
    Electronic ISSN: 1424-8220
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Published by MDPI Publishing
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  • 3
    Publication Date: 2016-05-23
    Description: Disease similarity study provides new insights into disease taxonomy, pathogenesis, which plays a guiding role in diagnosis and treatment. The early studies were limited to estimate disease similarities based ...
    Electronic ISSN: 1752-0509
    Topics: Biology
    Published by BioMed Central
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  • 4
    Publication Date: 2016-01-07
    Description: In genome-wide association studies (GWAS) for complex diseases, the association between a SNP and each phenotype is usually weak. Combining multiple related phenotypic traits can increase the power of gene sea...
    Electronic ISSN: 1471-2105
    Topics: Biology , Computer Science
    Published by BioMed Central
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  • 5
    Publication Date: 2016-02-21
    Description: In recent years, we have seen many applications of secure query in two-tiered wireless sensor networks. Storage nodes are responsible for storing data from nearby sensor nodes and answering queries from Sink. It is critical to protect data security from a compromised storage node. In this paper, the Communication-efficient Secure Range Query (CSRQ)—a privacy and integrity preserving range query protocol—is proposed to prevent attackers from gaining information of both data collected by sensor nodes and queries issued by Sink. To preserve privacy and integrity, in addition to employing the encoding mechanisms, a novel data structure called encrypted constraint chain is proposed, which embeds the information of integrity verification. Sink can use this encrypted constraint chain to verify the query result. The performance evaluation shows that CSRQ has lower communication cost than the current range query protocols.
    Electronic ISSN: 1424-8220
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Published by MDPI Publishing
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  • 6
    Publication Date: 2016-06-23
    Description: Nitrogen is an essential nutrient element in crop photosynthesis and yield improvement. Thus, it is urgent and important to accurately estimate the leaf nitrogen contents (LNC) of crops for precision nitrogen management. Based on the correlation between LNC and reflectance spectra, the hyperspectral LiDAR (HSL) system can determine three-dimensional structural parameters and biochemical changes of crops. Thereby, HSL technology has been widely used to monitor the LNC of crops at leaf and canopy levels. In addition, the laser-induced fluorescence (LIF) of chlorophyll, related to the histological structure and physiological conditions of green plants, can also be utilized to detect nutrient stress in crops. In this study, four regression algorithms, support vector machines (SVMs), partial least squares (PLS) and two artificial neural networks (ANNs), back propagation NNs (BP-NNs) and radial basic function NNs (RBF-NNs), were selected to estimate rice LNC in booting and heading stages based on reflectance and LIF spectra. These four regression algorithms were used for 36 input variables, including the reflectance spectral variables on 32 wavelengths and four peaks of the LIF spectra. A feature weight algorithm was proposed to select different band combinations for the LNC retrieval models. The determination coefficient (R2) and the root mean square error (RMSE) of the retrieval models were utilized to compare their abilities of estimating the rice LNC. The experimental results demonstrate that (I) these four regression methods are useful for estimating rice LNC in the order of RBF-NNs > SVMs > BP-NNs > PLS; (II) The LIF data in two forms, including peaks and indices, display potential in rice LNC retrieval, especially when using the PLS regression (PLSR) model for the relationship of rice LNC with spectral variables. The feature weighting algorithm is an effective and necessary method to determine appropriate band combinations for rice LNC estimation.
    Electronic ISSN: 2072-4292
    Topics: Architecture, Civil Engineering, Surveying , Geography
    Published by MDPI Publishing
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  • 7
    Publication Date: 2016-10-27
    Description: TET-mediated DNA demethylation controls gastrulation by regulating Lefty–Nodal signalling Nature 538, 7626 (2016). doi:10.1038/nature20095 Authors: Hai-Qiang Dai, Bang-An Wang, Lu Yang, Jia-Jia Chen, Guo-Chun Zhu, Mei-Ling Sun, Hao Ge, Rui Wang, Deborah L. Chapman, Fuchou Tang, Xin Sun & Guo-Liang Xu Mammalian genomes undergo epigenetic modifications, including cytosine methylation by DNA methyltransferases (DNMTs). Oxidation of 5-methylcytosine by the Ten-eleven translocation (TET) family of dioxygenases can lead to demethylation. Although cytosine methylation has key roles in several processes such as genomic imprinting and X-chromosome inactivation, the functional significance of cytosine methylation and demethylation in mouse embryogenesis remains to be fully determined. Here we show that inactivation of all three Tet genes in mice leads to gastrulation phenotypes, including primitive streak patterning defects in association with impaired maturation of axial mesoderm and failed specification of paraxial mesoderm, mimicking phenotypes in embryos with gain-of-function Nodal signalling. Introduction of a single mutant allele of Nodal in the Tet mutant background partially restored patterning, suggesting that hyperactive Nodal signalling contributes to the gastrulation failure of Tet mutants. Increased Nodal signalling is probably due to diminished expression of the Lefty1 and Lefty2 genes, which encode inhibitors of Nodal signalling. Moreover, reduction in Lefty gene expression is linked to elevated DNA methylation, as both Lefty–Nodal signalling and normal morphogenesis are largely restored in Tet-deficient embryos when the Dnmt3a and Dnmt3b genes are disrupted. Additionally, a point mutation in Tet that specifically abolishes the dioxygenase activity causes similar morphological and molecular abnormalities as the null mutation. Taken together, our results show that TET-mediated oxidation of 5-methylcytosine modulates Lefty–Nodal signalling by promoting demethylation in opposition to methylation by DNMT3A and DNMT3B. These findings reveal a fundamental epigenetic mechanism featuring dynamic DNA methylation and demethylation crucial to regulation of key signalling pathways in early body plan formation.
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 2016-12-08
    Description: A protein fragment derived from DNA-topoisomerase I as a novel tumour-associated antigen for the detection of early stage carcinoma British Journal of Cancer 115, 1555 (6 December 2016). doi:10.1038/bjc.2016.369 Authors: Shang-mian Yie, Shang-rong Ye, Xiao-li Ma, Ke Xie, Jian-bo Zhang, Mei Cao, Xu He, Zhen-bo Hu, Cheng-lu Yang, Jia Zhang & Jie Zeng
    Keywords: tumour-associated antigenautoantibodiesDNA-topoisomerase Iearly diagnosis of carcinomaTOPO48anti-TOPO48 autoantibodies
    Print ISSN: 0007-0920
    Electronic ISSN: 1532-1827
    Topics: Medicine
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