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  • 2005-2009  (6)
  • 1990-1994
  • 2005  (6)
  • 1
    Online Resource
    Online Resource
    London :Elsevier Science & Technology,
    Keywords: Neurobiology. ; Neurosciences. ; Electronic books.
    Description / Table of Contents: Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.
    Type of Medium: Online Resource
    Pages: 1 online resource (305 pages)
    Edition: 1st ed.
    ISBN: 9780080458311
    Series Statement: Issn Series ; v.Volume 63
    DDC: 573.8
    Language: English
    Note: front cover -- copyright -- table of contents -- contributors -- MAPPING NEURORECEPTORS AT WORK: ON THE DEFINITION AND INTERPRETATION OF BINDING POTENTIALS AFTER 20 YEARS OF PROGRESS -- I. Twenty Years of Progress -- II. Remaining Issues -- III. Solutions -- References 1 -- MITOCHONDRIAL DYSFUNCTION IN BIPOLAR DISORDER: FROM MAGNETIC RESONANCE SPECTROSCOPIC FINDINGS TO THEIR MOLECULAR MECHANISMS -- I. Introduction 2 -- II. Phosphorus-31 Magnetic Resonance Spectroscopy -- III. Near-Infrared Spectroscopy -- IV. Molecular Genetic Findings -- V. Roles of Mitochondrial Calcium Regulation -- VI. Conclusions -- References 2 -- LARGE-SCALE MICROARRAY STUDIES OF GENE EXPRESSION IN MULTIPLE REGIONS OF THE BRAIN IN SCHIZOPHRENIA AND ALZHEIMER'S DISEASE -- I. Introduction 3 -- II. Gene Expression Profiling Using Microarrays: Technologies Overview -- III. Postmortem Brains and Gene Expression Studies -- IV. Comparison of Gene Expression Profiles among Normal Brain Regions -- V. Gene Expression Profiles of Brain Regions in Alzheimer's Disease -- VI. Gene Expression Profiling in Schizophrenia -- VII. Future Perspectives -- References 3 -- REGULATION OF SEROTONIN 2C RECEPTOR PRE-mRNA EDITING BY SEROTONIN -- I. Introduction 4 -- II. Modification of RNA Sequences by RNA Editing via Hydrolytic Deaminations of Adenosines -- III. Enzymes Responsible for A-to-I Editing and Their Substrate Requirements -- IV. A-to-I Editing of the 5- HT2C Receptor Pre- mRNA -- V. Modulation of 5- HT2C Receptor Function by RNA Editing -- VI. 5- HT2C Pre- mRNA Editing Responses to Sustained Changes of Postsynaptic 5-HT2C Receptor Activation -- VII. 5- HT2C Pre- mRNA Editing in the Human Prefrontal Cortex and Alterations in Editing-Site Preferences in Brains of Subjects with Major Depression -- VIII. Conclusions and Future Directions -- References 4. , THE DOPAMINE HYPOTHESIS OF DRUG ADDICTION: HYPODOPAMINERGIC STATE -- I. Drug Addiction as a Brain Disease -- II. The Mesolimbic Dopamine System -- III. Behavioral Animal Models -- IV. Biochemical Studies -- V. Primate Studies -- VI. Conclusions -- Acknowledgments 5 -- References 5 -- HUMAN AND ANIMAL SPONGIFORM ENCEPHALOPATHIES ARE AUTOIMMUNE DISEASES: A NOVEL THEORY AND ITS SUPPORTING EVIDENCE -- I. Introduction 6 -- II. A New Theory on the Mechanism of Pathogenesis of Spongiform Encephalopathies (SEs) -- III. Supporting Evidence -- IV. Early Diagnosis, Treatment, and Prevention of Various SE Diseases -- V. Conclusions -- Acknowledgments 6 -- References 6 -- ADENOSINE AND BRAIN FUNCTION -- I. Introduction 7 -- II. Regulation of Brain Adenosine Levels in the Central Nervous System -- III. Adenosine Receptors -- IV. Functions of Adenosine Receptors -- V. Adenosine-Dopamine Interactions in Brain -- VI. Phenotypes of Knockout Mice -- VII. Adenosine Receptors and Protection against Ischemic and Excitotoxic Brain Injuries -- VIII. Adenosine A2A Receptors and Neurodegenerative Disorders -- IX. Adenosine Receptors and Psychiatric Disorders -- X. Adenosine and the Regulation of Sleep- Wake Cycles -- XI. Adenosine and Epilepsy -- XII. Adenosine and Pain -- Acknowledgments 7 -- References 7 -- Index -- Contents of Recent Volumes.
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  • 2
    Online Resource
    Online Resource
    San Diego :Elsevier Science & Technology,
    Keywords: Serotonin. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (289 pages)
    Edition: 1st ed.
    ISBN: 9780080460765
    Series Statement: Issn Series
    Language: English
    Note: front cover -- copyright -- table of contents -- Preface -- SECTION I THE CHOLINERGIC SYSTEM -- PART I. INTRODUCTION -- I. Anatomy -- PART II. THE MUSCARINIC SYSTEM -- I. Anatomy -- II. Electrical Activity -- III. Interactions with Other Transmitters -- IV. Postsynaptic Cascades -- V. Other Topics -- PART III. THE NICOTINIC SYSTEM -- I. Microanatomy -- II. Functional Microanatomy -- III. Interactions with Other Transmitters -- IV. Learning -- V. Miscellaneous Topics -- Section I References -- Section I Further Reading -- SECTION II THE DOPAMINE SYSTEM -- Section II Further Reading -- Section II References -- IX. Miscellaneous Items -- VIII. Parkinson's Disease -- VII. Dopamine and Behavior -- VI. Dopamine and Learning -- V. Miscellaneous Items -- IV. Dopamine-Induced Signaling Cascades -- III. Interaction between Dopamine and other Transmitters -- II. Electrical Reactions -- I. Anatomy -- SECTION III THE NOREPINEPHRINE SYSTEM -- Section III Further Reading -- Section III References -- VIII. Miscellaneous Items -- VII. Memory and Learning (LTP) -- VI. Tropins and Cytokines -- V. Postsynaptic Cascades -- IV. Interactions with Other Transmitters -- III. Electrical Activity -- II. Functional Neuroanatomy -- I. Microanatomy -- SECTION IV THE ADRENALINE SYSTEM -- Section IV References -- SECTION V SEROTONIN SYSTEM -- Section V Further Readings -- Section V References -- VIII. Miscellaneous -- VII. Sleep -- VI. Serotonin and the Development of Neural Systems -- V. Serotonin and Synaptic Plasticity -- IV. Postsynaptic Cascades -- III. Interactions Between Serotonin and Other Neurotransmitter Systems -- II. Electrical Actions -- I. Anatomy -- SECTION VI CONCLUSION -- Section VI References -- Possibly Obscure Acronyms for some Readers -- index.
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  • 3
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: High-mobility group box chromosomal protein 1 (HMGB1) is a protein with both intranuclear functions and extracellular cytokine-like effects. In this report, we study possible candidate receptors for HMGB1 on macrophages (Mφ) and define pathways activated by HMGB1 binding. Bone marrow Mφ were prepared from Dark Agouti (DA) rats and stimulated in vitro with HMGB1. The kinetics of tumour necrosis factor (TNF) production, NO production, activation of p38 mitogen-activated protein kinase (MAPK), p44/42 MAPK- and SAPK/JNK-signalling pathways, nuclear translocation of nuclear factor kappa B (NF-κB) and HMGB1-induced upregulation of major histocompatibility complex (MHC) class II and CD86 were analysed. Mφ from interleukin (IL)-1 receptor type I–/–, Toll-like receptor 2 (TLR2–/–) and RAGE–/– mice were used to investigate the role of these receptors in HMGB1 signalling. HMGB1 induced TNF and NO production by Mφ, phosphorylation of all investigated MAP kinase pathways and NF-κB translocation, and expression of MHC class II was increased. Mφ from RAGE–/– mice produced significantly lower amounts of TNF, IL-1β and IL-6, while IL-1RI–/– and TLR2–/– Mφ produced cytokine levels comparable with wildtype controls in response to HMGB1 stimulation. We conclude that HMGB1 has the potential to induce a proinflammatory phenotype in Mφ, with RAGE as the major activation-inducing receptor.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Asthma is a common disease affecting an increasing number of children throughout the world. In asthma, pulmonary airways narrow in response to contraction of surrounding smooth muscle. The precise nature of functional changes during an acute asthma attack is unclear. The tree structure of ...
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Obtaining high-quality measurements close to a large earthquake is not easy: one has to be in the right place at the right time with the right instruments. Such a convergence happened, for the first time, when the 28 September 2004 Parkfield, California, earthquake occurred on the San Andreas fault ...
    Type of Medium: Electronic Resource
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  • 6
    Publication Date: 2016-10-05
    Description: We review current knowledge and understanding of the biology and ecology of the calanoid copepod Calanus helgolandicus in European waters, as well as provide a collaborative synthesis of data from 18 laboratories and 26 sampling stations in areas distributed from the northern North Sea to the Aegean and Levantine Seas. This network of zooplankton time-series stations has enabled us to collect and synthesise seasonal and multi-annual data on abundance, body size, fecundity, hatching success and vertical distribution of C. helgolandicus. An aim was to enable comparison with its congener Calanus finmarchicus, which has been studied intensively as a key component of European and north east Atlantic marine ecosystems. C. finmarchicus is known to over-winter at depth, whereas the life-cycle of C. helgolandicus is less well understood. Overwintering populations of C. helgolandicus have been observed off the Atlantic coast between 400 and 800 m, while in the Mediterranean there is evidence of significant deep-water populations at depths as great as 4200 m. The biogeographical distribution of C. helgolandicus in European coastal waters covers a wide range of habitats, from open ocean to coastal environments, and its contribution to mesozooplankton biomass ranges from 6% to 93%. Highest abundances were recorded in the Adriatic and off the west coast of Spain. C. helgolandicus is generally found in 9–20 °C water, with maximum abundances from 13–17 °C. In contrast, C. finmarchicus is found in cooler water between 0 and 15 °C, with peak abundances from 0 to 9 °C. As water has warmed in the North Atlantic over recent decades, the range of C. helgolandicus and its abundance on the fringes of its expanding range have increased. This review will facilitate development of population models of C. helgolandicus. This will not only help answer remaining questions but will improve our ability to forecast future changes, in response to a warming climate, in the abundance and distribution of this important species.
    Type: Article , PeerReviewed
    Format: text
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