In:
The Korean Journal of Parasitology, Korean Society for Parasitology, Vol. 58, No. 2 ( 2020-04-30), p. 195-200
Abstract:
Soil-transmitted helminths, including 〈 i 〉 Ascaris lumbricoides 〈 /i 〉 and 〈 i 〉 Trichuris trichiura 〈 /i 〉 , are important intestinal parasites mostly affecting younger people in developing countries. In 2014-2015, we performed mass fecal examinations targeting a total of 2,227 schoolchildren in 3 districts (South Dagon, North Dagon, and Hlaing-thar-yar) of Yangon Region, Myanmar, using the Kato-Katz thick smear technique. The egg positive children were subjected to a mass drug administration (MDA) using a single oral dose of 400 mg albendazole. The pre-treatment egg positive rate (EPG/person) of 〈 i 〉 A. lumbricoides 〈 /i 〉 averaged 17.2% (15,532); it was 25.2% (21,796), 14.2% (11,816), and 12.8% (12,983) in 3 districts, respectively, and that of 〈 i 〉 T. trichiura 〈 /i 〉 averaged 19.4% (1,074), and was 24.1% (1,040), 12.3% (852), and 21.2% (1,330) in 3 districts, respectively. Follow-up fecal examinations performed 4 months post-MDA revealed considerable decreases of 〈 i 〉 A. lumbricoides 〈 /i 〉 prevalence (EPG/person) to av. 8.3% (12,429), and 13.7% (17,640), 8.0% (7,797), and 4.5% (11,849) in 3 districts, respectively. However, 〈 i 〉 T. trichiura 〈 /i 〉 did not show any recognizable decrease in the prevalence (EPG/person) remaining at av. 18.2% (862), and 18.5% (888), 11.5% (812), and 23.3% (887) in 3 districts, respectively. The results demonstrated difficulty in short-term control of 〈 i 〉 T. trichiura 〈 /i 〉 by MDA using albendazole and suggested necessity of either a long-term MDA ( 〉 10 years) or changing the albendazole regimen into 2~3-day course (total 800 or 1,200 mg), or using an alternative drug/drug combination.
Type of Medium:
Online Resource
ISSN:
0023-4001
,
1738-0006
DOI:
10.3347/kjp.2020.58.2.195
Language:
English
Publisher:
Korean Society for Parasitology
Publication Date:
2020
detail.hit.zdb_id:
2163174-8
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