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  • 1
    Electronic Resource
    Electronic Resource
    Chemie des 2-Aminospiro[indan-1,3′-pyrrolidin]-Systems (1979)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 62 (1979), S. 2860-2866 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The chemistry of the 2-aminospiro[indan-1,3′-pyrrolidine]system2-Aminospir[indan-1,3′-pyrrolidines] 1 are easily synthesized from the α-hydroxyiminoketones 6 and 19 (Schemes 2 and 3, and 6 respectively). Removal of the N-acetyl group in the intermediate 8 of the trans series induces transposition to the 3a-aminomethyl-indano[2,1-b]pyrrolidine system. The configurations of all compounds have been determined by 1H-NMR. spectroscopy.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19790620837
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Design and Synthesis of 5-Lipoxygenase Inhibitors (1988)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 71 (1988), S. 1156-1176 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Based on the substrate specificity for 5-lipoxygenase and the known stereochemical course of the reaction, a hypothetical model of the enzyme active site was developed and used to design 2 types of selective inhibitors of 5-lipoxygenase. Both inhibitor types used aromatic rings in place of (Z)-olefins of the substrate and were designed to mimic the nonpolar end of arachidonic acid. One inhibitor type used a carboxylic-acid interaction with the O-binding centre of the enzyme in analogy with known cyclooxygenase inhibitors, whereas a second type employed a hydroxylamine function to interact with a presumed tyrosine or cysteinyl radical predicted to be in the enzyme active site. Selective 5-lipoxygenase inhibitors were 7-(hexyloxy) naphthalene-2-acetic acid (1) and N-methyl;-N(7-propoxynaphthalene-2-ethyl)hydroxylamine (2). Structure-activity relationships for both types of inhibitors are discussed.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19880710528
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Valenzisomerisierungen bei 3.4-Diaza-bicyclo[4.2.0]octadienen und -trienen (1969)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 102 (1969), S. 1928-1936 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Es wird über die Darstellung und das thermische Verhalten von Verbindungen mit dem 3.4-Diaza-bicyclooctadien- und -trien-Ringgerüst berichtet. Die Ergebnisse sprechen dafür, daß valenztautomere Gleichgewichte der Art 1 ⇌ 2 und 3 ⇌ 4 vorliegen, die Konzentration der monocyclischen Tautomeren aber so klein ist, daß diese nicht direkt nachgewiesen werden können.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19691020618
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    Paper (German National Licenses)
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