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  • 1
    Electronic Resource
    Electronic Resource
    Design and Synthesis of 5-Lipoxygenase Inhibitors (1988)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 71 (1988), S. 1156-1176 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Based on the substrate specificity for 5-lipoxygenase and the known stereochemical course of the reaction, a hypothetical model of the enzyme active site was developed and used to design 2 types of selective inhibitors of 5-lipoxygenase. Both inhibitor types used aromatic rings in place of (Z)-olefins of the substrate and were designed to mimic the nonpolar end of arachidonic acid. One inhibitor type used a carboxylic-acid interaction with the O-binding centre of the enzyme in analogy with known cyclooxygenase inhibitors, whereas a second type employed a hydroxylamine function to interact with a presumed tyrosine or cysteinyl radical predicted to be in the enzyme active site. Selective 5-lipoxygenase inhibitors were 7-(hexyloxy) naphthalene-2-acetic acid (1) and N-methyl;-N(7-propoxynaphthalene-2-ethyl)hydroxylamine (2). Structure-activity relationships for both types of inhibitors are discussed.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19880710528
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Chemie des 2-Aminospiro[indan-1,3′-pyrrolidin]-Systems (1979)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 62 (1979), S. 2860-2866 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The chemistry of the 2-aminospiro[indan-1,3′-pyrrolidine]system2-Aminospir[indan-1,3′-pyrrolidines] 1 are easily synthesized from the α-hydroxyiminoketones 6 and 19 (Schemes 2 and 3, and 6 respectively). Removal of the N-acetyl group in the intermediate 8 of the trans series induces transposition to the 3a-aminomethyl-indano[2,1-b]pyrrolidine system. The configurations of all compounds have been determined by 1H-NMR. spectroscopy.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19790620837
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Valenzisomerisierungen bei 3.4-Diaza-bicyclo[4.2.0]octadienen und -trienen (1969)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 102 (1969), S. 1928-1936 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Es wird über die Darstellung und das thermische Verhalten von Verbindungen mit dem 3.4-Diaza-bicyclooctadien- und -trien-Ringgerüst berichtet. Die Ergebnisse sprechen dafür, daß valenztautomere Gleichgewichte der Art 1 ⇌ 2 und 3 ⇌ 4 vorliegen, die Konzentration der monocyclischen Tautomeren aber so klein ist, daß diese nicht direkt nachgewiesen werden können.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19691020618
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    Paper (German National Licenses)
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  • 4
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    An interdisciplinary investigation of a recent submarine mass transport deposit at the continental margin off Uruguay (2011)
    AGU (American Geophysical Union)
    In:  Geochemistry, Geophysics, Geosystems, 12 (8). Q08009.
    Details
    Publication Date: 2019-09-23
    Description: Assessing frequency and extent of mass movement at continental margins is crucial to evaluate risks for offshore constructions and coastal areas. A multidisciplinary approach including geophysical, sedimentological, geotechnical, and geochemical methods was applied to investigate multistage mass transport deposits (MTDs) off Uruguay, on top of which no surficial hemipelagic drape was detected based on echosounder data. Nonsteady state pore water conditions are evidenced by a distinct gradient change in the sulfate (SO42−) profile at 2.8 m depth. A sharp sedimentological contact at 2.43 m coincides with an abrupt downward increase in shear strength from ∼10 to 〉20 kPa. This boundary is interpreted as a paleosurface (and top of an older MTD) that has recently been covered by a sediment package during a younger landslide event. This youngest MTD supposedly originated from an upslope position and carried its initial pore water signature downward. The kink in the SO42− profile ∼35 cm below the sedimentological and geotechnical contact indicates that bioirrigation affected the paleosurface before deposition of the youngest MTD. Based on modeling of the diffusive re-equilibration of SO42− the age of the most recent MTD is estimated to be 〈30 years. The mass movement was possibly related to an earthquake in 1988 (∼70 km southwest of the core location). Probabilistic slope stability back analysis of general landslide structures in the study area reveals that slope failure initiation requires additional ground accelerations. Therefore, we consider the earthquake as a reasonable trigger if additional weakening processes (e.g., erosion by previous retrogressive failure events or excess pore pressures) preconditioned the slope for failure. Our study reveals the necessity of multidisciplinary approaches to accurately recognize and date recent slope failures in complex settings such as the investigated area.
    Type: Article , PeerReviewed
    Format: text
    DOI: 10.1029/2011GC003669
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    OceanRep: Article in a Scientific Journal - peer-reviewed
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