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1

Digitale Medien

Radioimaging of implants in rats using Tc-99m-MDP (2001)

McCracken, Michael ; Lemons, Jack E. ; Zinn, Kurt ; [weitere]

Copenhagen : Munksgaard International Publishers

Clinical oral implants research 12 (2001), S. 0

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ISSN: 1600-0501

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: Abstract: Radiopharmaceutical isotopes are widely used clinically to detect tumors of osteogenic origin. One example is Technetium-99m methylene diphosphonate (Tc-99m-MDP). When viewed with a gamma camera, the concentration of the isotope (increased gamma activity) indicates an area of increased bone activity. This technology provides an opportunity to measure bone growth around implants in vivo. The purpose of this study was to measure Tc-99m-MDP activity around titanium alloy implants placed in the tibiae of rats. Some implant sites were treated with a growth factor; other sites served as controls. The hypothesis tested was that implants placed with a growth factor would have greater associated Tc-99m-MDP activity. Twelve adult male Sprague-Dawley rats were anesthetized and surgical access to the medial proximal tibiae was obtained. Titanium alloy screw implants were placed in six animals along with 65 μg of acidic fibroblast growth factor (FGF-1); the other six animals received implants only and served as controls. After five days, rats were injected with 1500 μCi of Tc-99m-MDP. After 3 hours, rats were imaged with a gamma camera. The Tc-99m-MDP intensity associated with each implant was quantified and the means for each group were compared using ANOVA. Implants treated with FGF-1 demonstrated significantly more Tc-99m-MDP activity than implants alone. This suggests that Tc-99m-MDP analysis may be a useful tool for determining bone growth around implants in laboratory animals in vivo.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1034/j.1600-0501.2001.012004372.x

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2

Digitale Medien

Histomorphological evaluation of loaded plate-form and root-form implants in Macaca mulatta monkeys (2002)

McCracken, Michael ; Lemons, Jack E. ; Jeffcoat, Marjorie ; [weitere]

Oxford, UK : Munksgaard International Publishers

Clinical oral implants research 13 (2002), S. 0

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ISSN: 1600-0501

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: Abstract: As part of a long-term evaluation of endosteal dental implants in primates, this paper describes the histological response to plate-form and root-form implants. Thirty-six primates received 48 mandibular distal abutment implants. After healing, the implants were restored with fixed partial dentures, which remained in function for two years. A subset of the group was ligated at the gingival sulcus to biologically stress tissues supporting the implants. Crestal bone height around implants was quantified using digital subtraction radiographic techniques. The ligated implants lost more crestal bone than non-ligated implants, as shown by ANOVA (P 〈 0.05). After retrieval, implants were embedded and sectioned for histomorphometric analysis including measurement of per cent osseointegration. Both plate-form and root-form non-ligated implants demonstrated about 60% osseointegration. When ligated, plate-form implants dropped to an average integration of only 34%, while root-form implants maintained 62% integration, a significant difference. These data show that in this primate model, plate-form and root-form implants maintained integration while in function for two years. When stressed with ligation, root-form implants maintained relative amounts of osseointegration, while per cent osseointegration of plate-form implants decreased.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1034/j.1600-0501.2002.130212.x

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3

Digitale Medien

Surface energy characterization of unalloyed titanium implants (1994)

Kilpadi, Deepak V. ; Lemons, Jack E.

Hoboken, NJ : Wiley-Blackwell

Journal of Biomedical Materials Research 28 (1994), S. 1419-1425

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ISSN: 0021-9304

Schlagwort(e): Chemistry ; Polymer and Materials Science

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Medizin , Technik allgemein

Notizen: Osteointegration is dependent on a variety of biomechanical and biochemical factors. One factor is the wettability of an implant surface that is directly influenced by its surface energy. This investigation used the Zisman plot to determine critical surface energy. The effects of surface treatment, bulk grain size, and surface roughness on the critical surface tension of unalloyed titanium (Ti) were examined. Radio frequency glow discharge-treated Ti had the highest critical surface tension, followed by the passivated and heat-sterlized conditions. Titanium with no surface treatment had the lowest critical surface tension. The surface energy of Ti with an average grain size of 23 μm was not significantly different from that with a grain size of 70 μm. Surface roughness was shown to cause significant difference in measurements and definitely should be considered in studies of this kind. © 1994 John Wiley & Sons, Inc.

Zusätzliches Material: 6 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/jbm.820281206

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4

Digitale Medien

Erratum (1995)

Kilpadi, Deepak V. ; Lemons, Jack E.

Hoboken, NJ : Wiley-Blackwell

Journal of Biomedical Materials Research 29 (1995), S. 1469-1469

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ISSN: 0021-9304

Schlagwort(e): Chemistry ; Polymer and Materials Science

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Medizin , Technik allgemein

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/jbm.820291119

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5

Digitale Medien

Handbook of bioactive ceramics. vol. 1, bioactive glasses and glass-ceramics and vol. 2, calcium phosphate and hydroxylapatite ceramics. T. Yamamuro L. Hench J. Wilson CRC Press, Boca Raton, FL, 1990. (1991)

Lemons, Jack E.

Hoboken, NJ : Wiley-Blackwell

Journal of Biomedical Materials Research 25 (1991), S. 903-904

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ISSN: 0021-9304

Schlagwort(e): Chemistry ; Polymer and Materials Science

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Medizin , Technik allgemein

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/jbm.820250709

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