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  • 1
    Electronic Resource
    Electronic Resource
    Induction of interleukin-2 receptor by tumor necrosis factor α on cultured ovarian tumor-associated lymphocytes (1992)
    Springer
    Cancer immunology immunotherapy 35 (1992), S. 83-91 
    Details
    ISSN: 1432-0851
    Keywords: TNFα ; CD8+ CTL ; IL-2R ; TIL/TAL
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have recently reported that autologous tumor-specific cytotoxic T lymphocyte (CTL) lines and clones can be developed from lymphocytes infiltrating ovarian malignant ascites (TAL). In this study, we investigated the biological effects of tumor necrosis factor α (TNFα) in the induction, expansion, long-term proliferation and lytic function of CD8+ TAL. TNFα up-regulated the IL-2 receptor (IL-2R) α chain (Tac antigen) on the surface of CD3+ CD8+ CD4− TAL, enhanced the proliferation of autologous tumor-specific CTL, and potentiated their lytic function in long-term cultures. Furthermore, in the induction and expansion phase of CD8+ TAL, the presence of TNFα was associated with a selective increase in CD8+ IL-2R+ (Tac+) cells, and subsequent decrease in CD4+ IL-2R+ (Tac+) cells. These results suggest that the observed facilitation of the outgrowth of CD8+ cells in TAL cultures may be due, at least in part, to the up-regulation of IL-2R, and indicate the usefulness of TNFα in the analysis of signalling in autologous tumor-reactive CTL.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01741854
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  • 2
    Electronic Resource
    Electronic Resource
    Activity of 2-fluoro-Ara AMP against gynecologic tumors in the soft agar assay (1986)
    Springer
    Investigational new drugs 4 (1986), S. 141-148 
    Details
    ISSN: 1573-0646
    Keywords: in vitro ; 2-fluoro-Ara AMP ; gynecologic tumors ; cross-resistance ; chemosensitivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary To characterize in vitro activity of 2-fluoro-Ara AMP and its relation to the activities of cisplatin and doxorubicin, 28 specimens from patients with gynecologic tumors (predominantly ovarian) were tested in a soft agar assay. Twenty-six of 28 (93%) grew when the medium was supplemented with four hormones (epidermal growth factor, hydrocortisone, estradiol-17, and insulin). Normal bone marrow cells were utilized as a biologic control to define in vitro concentrations of the three drugs. Tumors were exposed continuously to three different concentrations of each drug. 2-fluoro-Ara AMP was tested against 26 tumors, cisplatin against 24, and doxorubicin against 14. In vitro sensitivity was defined as ≥ 50% colony inhibition at a drug concentration within the bone marrow inhibitory range. Seven of 26 (27%) tumor specimens were sensitive to 2-fluoro-Ara AMP. Among these, four tumors were derived from previously treated patients. However, in the 2-fluoro-Ara AMP concentration range (0.26 μg/ml to 0.78 μg/ml) tested, five of eight (62.5%) tumors from untreated patients achieved IC50 compared to only seven of 18 (39%) tumors from treated patients. Five of six (83%) specimens demonstrated cross-sensitivity between cisplatin and 2-fluoro-Ara AMP. Seventeen of 18 (94%) specimens demonstrated cross-resistance between cisplatin and 2-fluoro-Ara AMP, and 13 of 13 (100%) specimens demonstrated cross-resistance between 2-fluoro-Ara AMP and doxorubicin. A higher proportion of tumors from previously untreated patients achieved ≥ 50% colony inhibition when exposed to 2-fluoro-Ara-AMP or cisplatin than did those from previously treated patients. Our data suggest that 2-fluoro-Ara AMP has in vitro activity against gynecologic tumors (predominantly ovarian). Tumors from untreated patients were more sensitive than tumors from treated patients. At all concentrations of 2-fluoro-Ara AMP tested, bone marrow cells were more sensitive than the tumor cells suggesting a concerning notion that the clinical efficacy of this agent could be compromised by the myelosuppressive properties of this agent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00194593
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