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  • American Meteorological Society  (3)
  • Elsevier  (1)
  • Springer  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Two recurrent nonsense mutations and a 4 bp deletion in a quasi-symmetric element in exon 37 of the NF1 gene (1995)
    Springer
    Human genetics 〈Berlin〉 96 (1995), S. 95-98 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We screened a total of 92 unrelated patients with neurofibromatosis type 1 (NF1) for mutations in exon 37 of the NF1 gene, by using temperature gradient gel electrophoresis. Two novel mutations were found: a 4 bp deletion in a so-called quasi-symmetric element (6789delTTAC) and a recurrent nonsense mutation, which was identified in two unrelated patients, at codon 2264 (C6792A). The independent origin of the latter mutation in two families was confirmed by haplotype analysis. The nonsense mutation and the 4 bp deletion are both predicted to lead to a truncated protein product lacking the Cterminal 20% (aproximately) of its sequence. The occurrence of three independent mutations among 92 NF1 patients at codons 2263–2264 (exon 37) suggests that a specific search for mutations in this area should be undertaken in screening programs for NF1 mutations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00214193
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    Paper (German National Licenses)
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  • 2
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    Tracking the Mediterranean outflow in the Gulf of Cadiz (2017)
    Elsevier
    In:  Progress in Oceanography, 157 . pp. 47-71.
    Details
    Publication Date: 2020-02-06
    Description: Highlights • We track the preferential pathways of the Mediterranean Outflow Water (MOW). • A topographic analysis method is used to identify the MOW hydrological avenues. • Contour avenues and cross-slope channels have complementary roles steering the MOW. • The MOW is a density-driven current steered by both bottom topography and the Coriolis force. Abstract The Mediterranean Water leaves the western end of the Strait of Gibraltar as a bottom wedge of salty and warm waters flowing down the continental slope. The salinity of the onset Mediterranean Outflow Water (MOW) is so high that leads to water much denser (initially in excess of 1.5 kg m−3) than the overlying central waters. During much of its initial descent, the MOW retains large salinity anomalies – causing density anomalies that induce its gravity current character – and relatively high westward speeds – causing a substantial Coriolis force over long portions of its course. We use hydrographic data from six cruises (a total of 1176 stations) plus velocity data from two cruises, together with high-resolution bathymetric data, to track the preferential MOW pathways from the Strait of Gibraltar into the western Gulf of Cadiz and to examine the relation of these pathways to the bottom topography. A methodology for tributary systems in drainage basins, modified to account for the Coriolis force, emphasizes the good agreement between the observed trajectories and those expected from a topographically-constrained flow. Both contour avenues and cross-slope channels are important and have complementary roles steering the MOW along the upper and middle continental slope before discharging as a neutrally buoyant flow into the western Gulf of Cadiz. Our results show that the interaction between bottom flow and topography sets the path and final equilibrium depths of the modern MOW. Furthermore, they support the hypothesis that, as a result of the high erosive power of the bottom flow and changes in bottom-water speed, the MOW pathways and mixing rates have changed in the geological past.
    Type: Article , PeerReviewed
    Format: text
    DOI: 10.1016/j.pocean.2017.05.015
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    OceanRep: Article in a Scientific Journal - peer-reviewed
  • 3
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    Mixing and entrainment in the Red Sea outflow plume. Part I : plume structure (2010)
    American Meteorological Society
    Details
    Publication Date: 2022-05-25
    Description: Author Posting. © American Meteorological Society, 2005. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Physical Oceanography 35 (2005): 569–583, doi:10.1175/JPO2679.1.
    Description: When the salty and heavy water of the Red Sea exits from the Strait of Bab el Mandeb, it continues downslope into the Gulf of Aden mainly along two channels. The 130-km-long “Northern Channel” (NC) is topographically confined and is typically only 5 km wide. In it, the Red Sea plume shows unanticipated patterns of vertical structure, turbulent mixing, and entrainment. Above the seafloor a 25–120-m-thick weakly stratified layer shows little dilution along the channel. Hence this bottom layer undergoes only weak entrainment. In contrast, a 35–285-m-thick interfacial layer shows stronger entrainment and is shown in a companion paper to undergo vigorous turbulent mixing. It is thus the interface that exhibits the bulk of entrainment of the Red Sea plume in the NC. The interfacial layer also carries most of the overall plume transport, increasingly so with downstream distance. The “Southern Channel” (SC) is wider than the NC and is accessed from the latter by a sill about 33 m above the floor of the NC. Entrainment into the bottom layer of the SC is diagnosed to be strong near the entry into the SC such that the near-bottom density and salinity are smaller in the SC than in the NC at the same distance from Bab el Mandeb. In comparison with winter conditions, the authors encountered weaker outflow with shallower equilibration depths during the summer cruise. Bulk Froude numbers computed for the whole plume varied within the range 0.2–1. Local maxima occurred in relatively steep channel sections and coincided with locations of significant entrainment.
    Description: The Red Sea Outflow Experiment was funded by the National Science Foundation under Contracts OCE-9819506 and OCE-9818464. Additional support was provided to the “Climate Process Team Gravity Currents” under OCE-0336799.
    Repository Name: Woods Hole Open Access Server
    Type: Article
    Format: application/pdf
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  • 4
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    Equilibration and circulation of Red Sea Outflow water in the western Gulf of Aden (2010)
    American Meteorological Society
    Details
    Publication Date: 2022-05-25
    Description: Author Posting. © American Meteorological Society, 2005. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Physical Oceanography 35 (2005): 1963–1985, doi:10.1175/JPO2787.1.
    Description: Hydrographic, direct velocity, and subsurface float observations from the 2001 Red Sea Outflow Experiment (REDSOX) are analyzed to investigate the gravitational and dynamical adjustment of the Red Sea Outflow Water (RSOW) where it is injected into the open ocean in the western Gulf of Aden. During the winter REDSOX cruise, when outflow transport was large, several intermediate-depth salinity maxima (product waters) were formed from various bathymetrically confined branches of the outflow plume, ranging in depth from 400 to 800 m and in potential density from 27.0 to 27.5 σθ, a result of different mixing intensity along each branch. The outflow product waters were not dense enough to sink to the seafloor during either the summer or winter REDSOX cruises, but analysis of previous hydrographic and mooring data and results from a one-dimensional plume model suggest that they may be so during wintertime surges of strong outflow currents, or about 20% of the time during winter. Once vertically equilibrated in the Gulf of Aden, the shallowest RSOW was strongly influenced by mesoscale eddies that swept it farther into the gulf. The deeper RSOW was initially more confined by the walls of the Tadjura Rift, but eventually it escaped from the rift and was advected mainly southward along the continental slope. There was no evidence of a continuous boundary undercurrent of RSOW similar to the Mediterranean Undercurrent in the Gulf of Cadiz. This is explained by considering 1) the variability in outflow transport and 2) several different criteria for separation of a jet at a sharp corner, which indicate that the outflow currents should separate from the boundary where they are injected into the gulf.
    Description: This work was supported by the U.S. National Science Foundation under Grants OCE-9818464 (WHOI) and OCE-9819506 (RSMAS).
    Repository Name: Woods Hole Open Access Server
    Type: Article
    Format: application/pdf
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  • 5
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    Improving oceanic overflow representation in climate models : the Gravity Current Entrainment Climate Process Team (2010)
    American Meteorological Society
    Details
    Publication Date: 2022-05-26
    Description: Author Posting. © American Meteorological Society, 2009. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Bulletin of the American Meteorological Society 90 (2009): 657-670, doi:10.1175/2008BAMS2667.1.
    Description: Oceanic overflows are bottom-trapped density currents originating in semienclosed basins, such as the Nordic seas, or on continental shelves, such as the Antarctic shelf. Overflows are the source of most of the abyssal waters, and therefore play an important role in the large-scale ocean circulation, forming a component of the sinking branch of the thermohaline circulation. As they descend the continental slope, overflows mix vigorously with the surrounding oceanic waters, changing their density and transport significantly. These mixing processes occur on spatial scales well below the resolution of ocean climate models, with the result that deep waters and deep western boundary currents are simulated poorly. The Gravity Current Entrainment Climate Process Team was established by the U.S. Climate Variability and Prediction (CLIVAR) Program to accelerate the development and implementation of improved representations of overflows within large-scale climate models, bringing together climate model developers with those conducting observational, numerical, and laboratory process studies of overflows. Here, the organization of the Climate Process Team is described, and a few of the successes and lessons learned during this collaboration are highlighted, with some emphasis on the well-observed Mediterranean overflow. The Climate Process Team has developed several different overflow parameterizations, which are examined in a hierarchy of ocean models, from comparatively well-resolved regional models to the largest-scale global climate models.
    Description: The Gravity Current Entrainment Climate Process Team was funded by NSF grants OCE-0336850 and OCE-0611572 and NOAA as a contribution to U.S.CLIVAR.
    Repository Name: Woods Hole Open Access Server
    Type: Article
    Format: application/pdf
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