Description: Due to their favorable P-T conditions and organic-rich deposits, sub-seafloor sediments in the northern Gulf of Mexico are known to have a large potential for gas hydrate accumulations. The presence of gas hydrates within sediments of the Green Canyon block has been proven by various methods, incl. seismic imaging, geochemical analysis, and drilling conducted mainly as a part of Joint Industry Project (JIP) Phase II. Gas hydrates reported therein usually occur as tens up to hundreds of meters thick sections with moderate to high concentrations within a range of 50 – 70 vol. % of pore space, and hence, seem to offer a considerable natural deposit of methane gas. The main focus of this study was to explore the complex effects of a set of control- parameters responsible for hydrocarbon migration and storage within the Gas Hydrate Stability Zone (GHSZ) on the accumulation of gas hydrates. To investigate the processes of basin formation and its subsidence history, source rock maturation, hydrocarbon migration and expulsion, and to quantify the gas hydrate accumulation potential, 3-D numerical study has been conducted using PetroMod. The area of interest extends over ~14 km x 33 km and covers the edge of the Sigsbee Escarpment representing the main salt mobility front in the region. The simulation contains full depositional history of the Green Canyon block, incl. salt deposition and re-mobilization as well as its further implications for temperature field, fluids migration and sedimentary layers distribution. Methane generation has been resolved by in-situ POC degradation and deep thermogenic mobilization from two distinct hydrocarbon sources. As a result, we present a number of likely scenarios of gas hydrate formation and accumulation in the study area that have been calibrated against available data.