ISSN:
1440-1681
Quelle:
Blackwell Publishing Journal Backfiles 1879-2005
Thema:
Medizin
Notizen:
1. Polyriboinosinic-polyribocytidylic acid (Poly I:Poly C), an interferon inducer was studied for its effect on gastric ulceration in rats. Polyriboinosinic-polyribocytidylic acid (1,2 and 4 mg/kg, i.m.) showed a dose-dependent inhibition of gastric ulcers induced by aspirin, cold restraint stress and pylorus ligation (Shay's model). Protective dose (PD50)±SEM values of Poly I:Poly C on these models of ulcers were 1.9±0.2, 2.3±0.4 and 2.8±0.4 (mg/kg, i.m.) respectively.2. Polyriboinosinic-polyribocytidylic acid (10-60 μg) produced dose-dependent inhibition of gastric proton pump (H+/K+-ATPase) activity in the gastric parietal microsomal fraction. The concentration of Poly I:Poly C causing a 50% inhibition (IC50)±SEM was found to be 17.6±1.2 μg.3. Polyriboinosinic-polyribocytidylic acid caused a significant decrease in free and total acid and pepsin and an increase in mucin content in Shay (pylorus-ligated) rat.4. Polyriboinosinic-polyribocytidylic acid did not exert a significant influence on isolated tissue preparations for anticholinergic (acetylcholine-induced contraction of guinea-pig ileum) and H2-anti-histaminic (histamine-induced contraction of rat uterus and guinea-pig auricle) activities.5. Thus, the present study indicates that Poly I:Poly C may possess anti-gastric ulcer activity as a result of inhibition of the gastric proton pump.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1111/j.1440-1681.1998.tb02252.x
