ISSN:
1432-1327
Schlagwort(e):
Key words Cisplatin
;
Guanosine monophosphate
;
Dinucleotide
;
Nucleotide
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Biologie
,
Chemie und Pharmazie
Notizen:
Abstract The interaction of the new antitumor-active platinum organoamide complexes [Pt{N(p–HC6F4)CH2}2(py)2] and [Pt{N(C6F5)CH2}2(py)2] (py = pyridine) with small G-containing (oligo)nucleotides [GMP, d(GpG)] has been studied to establish whether or not these compounds can bind to DNA in an analogous manner to cisplatin. The reaction products have been analyzed by 1H, 19F and 31P NMR spectroscopy. From the NMR data it is concluded that the {Pt(py)2}2+ moiety binds to the N7 position of the G base, analogously to cisplatin, with the organoamide ligand acting as the leaving group. For the GG-N7,N7 adduct, structural differences are found for the sugar conformation, compared with cisplatin. These differences may account for the activity of these new compounds in tumor cell lines resistant to cisplatin.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/s007750050054
