Description: This article presents a multidisciplinary approach to the assessment of slope deformation at the Lower Hodruša mining water reservoir, which is part of a UNESCO cultural heritage site. The multidisciplinary approach was used to develop remedial measures. The Lower Hodruša mining water reservoir is situated in the Hodruša-Hámre municipality near Banská Štiavnica in the central part of Slovakia. The first mention of the construction of the reservoir is from 1743, and according to historical records, there were problems with slope stability already at that time. Nowadays, to increase the volume of water available for technical operations in the Hodruša valley, the decision was made to increase the dam’s output capacity. Slope movements were first detected while the reservoir was being drained. A part of the left shore 50 to 150 m from the dam crest moved, damaging adjacent buildings. The Hodruša-Hámre municipal authorities declared an emergency on 24 August 2015 because of the appearance of cracks in the asphalt surface of the national road and its subsidence. The main discontinuity conformed approximately to the contours of the known landslide area on the south side of the reservoir. The significant deformations involving the 0.20-m subsidence of the service road were reported during heavy rainfall in October 2014. A range of geoscientific disciplines was used to develop a detailed description of the landslide area and to determine the cause of the slope deformation. The depth and course of the shear surface were measured using boreholes and geophysical methods; the historic development of the landslide was analysed using dendrochronological measurements; and the present horizontal and vertical movement of the landslide over one and half years was determined using geodetic monitoring based on a network of stabilised points and inclinometer measurements.