Publication Date:
2014-12-18
Description:
Experiments on labeling of diclofenac, an anti-inflammatory drug, with 99 m Tc were performed. High (about 96%) yield of 99 m Tc-diclofenac is reached under the following conditions: 50 μg of Sn(II), 100 μg of the substrate, 30 min, pH 7. 99 m Tc-diclofenac was stable for 4 h. Biological distribution of 99 m Tc-diclofenac was investigated in mice bearing inflammations experimentally induced in the left thigh by Escherichia coli (bacterial infection model) and turpentine oil (sterile inflammation model). The uptake ratio in the inflamed and contralateral thighs (target-to-nontarget, T/NT) was evaluated. In the case of bacterial infection, the T/NT ratio only slightly exceeds unity, whereas in the case of sterile inflammation it reaches 4.46 ± 0.07 in 2 h. Thus, 99 m Tc-diclofenac allows differentiation between septic and aseptic inflammation and can be recommended for further clinical trials.
Print ISSN:
1066-3622
Electronic ISSN:
1608-3288
Topics:
Chemistry and Pharmacology
