Publication Date:
2014-12-15
Description:
Publication date: Available online 13 December 2014 Source: FEBS Open Bio Author(s): Tadaho Nakamura , Takeo Yoshikawa , Fumito Naganuma , Attayeb Mohsen , Tomomitsu Iida , Yamato Miura , Akira Sugawara , Kazuhiko Yanai Pancreatic α-cells secrete glucagon to maintain energy homeostasis. Although histamine has an important role in energy homeostasis, the expression and function of histamine receptors in pancreatic α-cells remains unknown. We found that the histamine H 3 receptor (H 3 R) was expressed in mouse pancreatic α-cells and αTC1.6 cells, a mouse pancreatic α-cell line. H 3 R inhibited glucagon secretion from αTC1.6 cells by inhibiting an increase in intracellular Ca 2+ concentration. We also found that immepip, a selective H 3 R agonist, decreased serum glucagon concentration in rats. These results suggest that H 3 R modulates glucagon secretion from pancreatic α-cells.
Electronic ISSN:
2211-5463
Topics:
Biology
