In:
Arquivos do Mudi, Universidade Estadual de Maringa, Vol. 27, No. ESPECIAL ( 2023-05-10)
Kurzfassung:
Maternal nutritional insults during lactation can modulate the offspring phenotype associatedwith the risk of non-communicable diseases at different stages of ontogenetic development.The aim of this research was to analyze biometric and biochemical parameters of male Wistarrats, born to dams fed a low-protein diet in the first two-thirds of lactation. Therefore, themothers received ad libitum a normal (NP, 23%) or low-protein (LP, 4%) diet, originatingtwo experimental groups that were evaluated at 14 days old (NP-14 and LP-14). The resultsshowed that the LP-14 offspring male rats had lower body weight (p & lt;0.0001), reduced liver(p & lt;0.0001) and higher brown fat deposits (p & lt;0.0001), compared to the equivalent control.They also exhibited hyperglycemia (p & lt;0.05), hypercholesterolemia (p & lt;0.0001), and increasedserum β-hydroxybutyrate (p & lt;0.0001), contrasting with reduced triglycerides (p & lt;0.05) levels.We conclude that maternal exposure to a low-protein diet during lactation was able toprogram 14-day-old male neonates to develop a metabolic syndrome phenotype, probably dueto restriction of body and visceral growth in these animals.
Materialart:
Online-Ressource
ISSN:
1980-959X
,
1980-959X
DOI:
10.4025/arqmudi.v27iESPECIAL
DOI:
10.4025/arqmudi.v27iESPECIAL.68185
Sprache:
Unbekannt
Verlag:
Universidade Estadual de Maringa
Publikationsdatum:
2023