In:
Journal of Cell Science, The Company of Biologists, Vol. 134, No. 12 ( 2021-06-15)
Kurzfassung:
Repressor element 1-silencing transcription factor (REST) plays a crucial role in the differentiation of neural progenitor cells (NPCs). C-terminal domain small phosphatases (CTDSPs) are REST effector proteins that reduce RNA polymerase II activity on genes required for neurogenesis. miR-26b regulates neurogenesis in zebrafish by targeting ctdsp2 mRNA, but the molecular events triggered by this microRNA (miR) remain unknown. Here, we show in a murine embryonic stem cell differentiation paradigm that inactivation of miR-26 family members disrupts the formation of neurons and astroglia and arrests neurogenesis at the neural progenitor level. Furthermore, we show that miR-26 directly targets Rest, thereby inducing the expression of a large set of REST complex-repressed neuronal genes, including miRs required for induction of the neuronal gene expression program. Our data identify the miR-26 family as the trigger of a self-amplifying system required for neural differentiation that acts upstream of REST-controlled miRs.
Materialart:
Online-Ressource
ISSN:
0021-9533
,
1477-9137
Sprache:
Englisch
Verlag:
The Company of Biologists
Publikationsdatum:
2021
ZDB Id:
219171-4
ZDB Id:
1483099-1
SSG:
12
