In:
Tumori Journal, SAGE Publications, Vol. 72, No. 4 ( 1986-08), p. 345-350
Abstract:
Growth of MCA-38/B colon adenocarcinoma was detectable 30-33 days after subcutaneous (s.c.) tumor cell inoculation in mice. Seventy percent of the mice receiving 10 7 tumor cells, 50 % of those receiving 10 4 , and 15% of the mice given 10 5 cells developed s.c. tumors (mean of 4 experiments, total of 80 mice per group). Metastases in the presence of a primary tumor were observed in 11% of 10 7 and in 10% of 10 6 tumor-cell injected animals. Lung metastases were detected in the absence of tumor growth at the site of s.c. cell injection in 19% of 10 7 , in 8% of 10 6 and in 5% of 10 5 and 10 4 tumor-cell inoculated mice. In parallel experiments an intravenous (i.v.) inoculum of tumor cells produced lung colonies in 40% of 10 6 and in 14% of 10 5 tumor-cell injected animals. Smaller inocula did not give rise to lung colonies, thus making it unlikely that accidental i.v. inoculations of tumor cells during the s.c. injections caused the observed metastatic dissemination to the lungs.
Type of Medium:
Online Resource
ISSN:
0300-8916
,
2038-2529
DOI:
10.1177/030089168607200402
Language:
English
Publisher:
SAGE Publications
Publication Date:
1986
detail.hit.zdb_id:
280962-X
detail.hit.zdb_id:
2267832-3
