In:
Organic Chemistry Frontiers, Royal Society of Chemistry (RSC), Vol. 9, No. 3 ( 2022), p. 757-763
Abstract:
A facile silver-catalyzed dual decarboxylation of arylthio-difluoroacetic acid with coumarin-3-carboxylic acids/chromone-3-carboxylic acids was developed. This method provided a unique way to synthesize a series of C-4 arylthiodifluoromethylated 3,4-dihydrcoumarins/C-2 arylthiodifluoro-methylated chromanone derivatives in moderate to good yields under mild conditions. Mechanistic studies confirmed that the methodology proceeds via a bimolecular decarboxylative radical pathway. In addition, experimental studies showed that the C-3 carboxyl group of coumarin-3-carboxylic acids/chromone-3-carboxylic acids and the CF 2 group of arylthiodifluoroacetic acids play a crucial role in this transformation.
Type of Medium:
Online Resource
ISSN:
2052-4129
Language:
English
Publisher:
Royal Society of Chemistry (RSC)
Publication Date:
2022