Electronic Resource
Springer
Archives of virology
7 (1957), S. 307-332
ISSN:
1432-8798
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The incubation time titration method has been applied to a study of the neutralization of adenovirus by antibody. Following dilution of mixtures of virus and serum a marked “reactivation phenomenon” was apparent. The results indicate that this phenomenon was partly caused by remaining reactive antibody in the medium, partly by a faster and more extensive reaction between virus and serum in higher concentrations. Whether or not a real reactivation also contributed to the “dilution effect” cannot be definitely decided upon. The results indicated, furthermore, that antibody may influence the virus in another way than by a complete inactivation. This effect was correlated to the dose of inoculum. Some possibilities regarding the mechanism of the phenomenon are discussed. With suitable concentrations of virus the incubation time titration method has been found applicable for routine work.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01240740
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