ISSN:
1432-0533
Keywords:
Progressive Multifocal Leukoencephalopathy
;
CNS Demyelination, Progressive
;
Leukemia
;
Papovavirus in CNS
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In 7 cases of progressive multifocal leukoencephalopathy (PML), five with papova-like viral inclusions, the clinical and neuropathological features varied both within the group and in relation to the accepted, uniform pattern of the disease. Two were „spontaneous” and unrelated to any disease. One ran a protracted, remitting course, and in another the disease appeared stationary. From different points of view the differential diagnosis of multiple sclerosis was considered in these two cases. Two or three were subclinical, a variety which may be more common than hitherto recognized. Pronounced asymmetry in the distribution of lesions appears to be diagnostic interest in this disease, which would be expected to involve the brain in a generalized manner. The occurrence of atypical astrocytes, regarded as a striking feature of old lesions, was unimpressive except in two cases. These two cases on the other hand showed a glial reaction, in some respects simulating a glioma. This was deemed of particular interest in connection with an infection with the papova-group of viruses which is used experimentally to induce tumour. Recent results of virological research in this field can be expected to provide new and better means to study the virus, its occurrence in man and its possible role in PML.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00687593
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