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  • 1
    Publikationsdatum: 2014-11-11
    Beschreibung: Publication date: Available online 4 November 2014 Source: International Journal of Production Economics Author(s): Klaus Reinholdt Nyhuus Hansen , Martin Grunow Shorter product life cycles and the resulting increase in new product introductions boost the importance of product launch operations. In the pharmaceutical sector, product launch operations are of particular importance, as companies seek to reduce time-to-market to better exploit patent protection. Large volumes of product need to be ready to fill the downstream supply chain immediately at market launch. Building up the required inventory is, however, connected to several risks. In addition to the risk associated with the lack of demand information for a new product, there are several risks unique to the pharmaceutical sector. After approval by central authorities such as the FDA or EMA, a new drug still needs to receive market authorization, which is in most cases granted by some local authorities - in Europe, for example, by more than 30 national and regional bodies. The duration of these different market authorization processes as well as their outcomes (e.g. price and reimbursement levels, requirements of label or leaflet changes) are highly uncertain. We develop a two-stage stochastic model to support market launch preparation decisions. It trades off the costs of accepting these risks, for example by risk packaging before authorization, against the lost revenue caused by risk-averse operations. The model is applied to a case based on an empirical study. Our approach results in significant savings compared to current practices. We hereby provide an example of how quantitative methodology can provide valuable decision support for product launch operations, even when complex regulatory affairs need to be considered.
    Print ISSN: 0925-5273
    Digitale ISSN: 1873-7579
    Thema: Technik allgemein , Wirtschaftswissenschaften
    Publiziert von Elsevier
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Publikationsdatum: 2022-02-18
    Beschreibung: Based on the European Waste Framework Directive and the German Recycling Management Act of 01.06.2012 the objectives for a national waste prevention programme were defined. As main objective, according to art. 1 WFD, the "prevention or reduction of the disadvantageous impacts of waste generation and management on the human health and the environment" is recommended. Indicators for a quantitative and qualitative monitoring are derived for both, the individual measures as well as for a waste prevention programme.
    Schlagwort(e): ddc:320
    Repository-Name: Wuppertal Institut für Klima, Umwelt, Energie
    Sprache: Englisch
    Materialart: report , doc-type:report
    Format: application/pdf
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  • 3
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie | Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publikationsdatum: 2022-02-18
    Beschreibung: This report presents the findings and recommendations of the EMI case study undertaken as part of the Digital Europe project. Chapter 2 sets out the background to the case study; chapter 3 investigates the environmental impacts of digital music; and chapter 4 highlights the social impacts of digital music. Chapter 5 outlines future scenarios for the sector and chapter 6 draws recommendations for business and government.
    Schlagwort(e): ddc:600
    Repository-Name: Wuppertal Institut für Klima, Umwelt, Energie
    Sprache: Englisch
    Materialart: report , doc-type:report
    Format: application/pdf
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  • 4
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    International Phycological Society
    In:  Phycologia, 52 (4, Supplement). p. 119.
    Publikationsdatum: 2019-09-23
    Beschreibung: To evaluate the importance of anti-herbivore resistance for algal invasion success we compared resistance traits among specimens of the red macroalga Gracilaria vermiculophylla from six native populations in Korea and China and eight invasive populations in Europe and Mexico that were maintained under identical conditions in the laboratory. Herbivorous snails both from the native range (Littorina brevicula) and from the invaded range (Littorina littorea) consumed significantly less of seaweed specimens originating from non-native populations. Metabolome profiling revealed that this preference was correlated with an increased woundactivated production of deterring prostaglandins and hydroxyeicosatetraenoic acids. Thus, invasive populations of G. vermiculophylla are more strongly defended against challenge by herbivores and other biological enemies that cause local tissue or cell disruption and activate oxylipin production. Anthropogenic distribution of genotypes adapted to resist elevated feeding pressure probably contributed to the invasion success of this species.
    Materialart: Article , PeerReviewed
    Format: text
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Publikationsdatum: 2019-09-23
    Beschreibung: Grazing by the isopod Idotea baltica induces chemical defenses in the brown seaweed Fucus vesiculosus. A combination of a 33 day induction experiment, feeding choice assays and functional genomic analyses was used to investigate temporal defense patterns and to correlate changes in palatability to changes in gene expression. Despite permanent grazing, seaweed palatability varied over time. Controls were significantly more consumed than grazed pieces only after 18 and 27 days of grazing. Relative to controls, 562/402 genes were up-/down-regulated in seaweed pieces that were grazed for 18 days, i.e. when defense induction was detected. Reprogramming of the regulative expression orchestra (translation, transcription), up-regulation of genes involved in lipid and carbohydrate metabolism, intracellular trafficking, defense and stress response, as well as downregulation of photosynthesis was found in grazed seaweed. These findings indicate short-term temporal variation in defenses and that modified gene expression patterns arise at the same time when grazed seaweed pieces show reduced palatability. Several genes with putative defensive functions and cellular processes potentially involved in defence, such as reallocation of resources from primary to secondary metabolism, were revealed
    Materialart: Article , PeerReviewed
    Format: text
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  • 6
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    DCE – Danish Centre for Environment and Energy, Aarhus Univ.
    Publikationsdatum: 2020-02-12
    Beschreibung: This book is about management of arctic and northern alpine research stations. It has been produced by a group of station managers participating in the EU 7th Framework Programme Infrastructure project called INTERACT. With this book we want to share the knowledge and experiences we have gained from managing very different research stations in very different environmental and climatic settings. The target audience for the book is mainly managers of research stations in arctic and alpine areas, but we hope that it will also be useful for others involved in science coordination and logistics, e.g. research institutions, chief scientists and expedition planners. The book has been produced mainly based on input from practising station managers being part of ‘INTERACT Station Managers’ Forum (SMF), a forum established to provide a platform for exchange of information between station managers and other participants within INTERACT, and to collect and disseminate knowledge embedded within the network. The scope of this book is to identify and describe best practices and key considerations of relevance to station management under arctic and alpine conditions. As research stations operate under very different legal regimes, financial conditions, environmental and climatic conditions, as well as remoteness, it is not possible to identify specific best practices that fit all stations. Instead, we have described key issues that should be considered and addressed by station management, and supplemented this with examples of good practices from stations operating under different conditions (e.g. different climate, remoteness or size).
    Sprache: Englisch
    Materialart: info:eu-repo/semantics/book
    Format: application/pdf
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  • 7
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    IAHS Press
    Publikationsdatum: 2017-04-04
    Beschreibung: Population growth, urbanization and global climate change have increased urban and agricultural water demands, stressing aquifer systems where groundwater is a source of water supply. The availability and utility of groundwater may further be threatened by factors stressing the quality of groundwater, such as industrial and domestic wastes and agricultural intensification. Consequences include, for example, over-allocation of groundwater, groundwater overdraft, declining well yields and land subsidence; degraded groundwater quality due to mobilization of natural pollutants (arsenic), salt contamination caused by seawater intrusion; increased demand for conjunctively used surface water, and resulting conflicts with junior users; and streamflow capture and resulting damage to ecosystems. These consequences may occur incrementally and inequitably across an aquifer. Natural environmental problems can further complicate use of groundwater and increase strain on the aquifer system; for example, underground structures, geothermal heating (such as heat islands), and geochemical evolution (such as karst formation, excessive salinity, acidity, fluoride, radioactivity, hardness, or turbidity). To address this issue, a joint symposium on the Trends and Sustainability of Groundwater in Highly Stressed Aquifers was held during the 8th Scientific Assembly of the International Association of Hydrological Sciences, IAHS, and the 37th Congress of the International Association of Hydrogeology, IAH, in Hyderabad, India, September 2009. The symposium was organized by the IAHS International Commission on Groundwater (ICGW), supported IAH and by the IAHS International Commission on Water Quality (ICWQ). This symposium brought together scientists, including modellers, geochemists and hydro-geologists, with water supply managers and policy makers to discuss scientific and management ideas and approaches for improving the sustainability of highly stressed aquifers. The importance of this topic was reflected in the large number of contributions to the symposium. Selected papers from this symposium have been compiled in this volume. The editors gratefully acknowledge the assistance of the reviewers who made valuable contributions to this volume. We thank Penny Perrins and Cate Gardner from IAHS Press for their professional approach and help with the processing of the manuscripts.
    Beschreibung: Published
    Beschreibung: V
    Beschreibung: open
    Schlagwort(e): goundwater ; 03. Hydrosphere::03.02. Hydrology::03.02.03. Groundwater processes
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: book chapter
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  • 8
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie | Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publikationsdatum: 2022-02-18
    Schlagwort(e): ddc:600
    Repository-Name: Wuppertal Institut für Klima, Umwelt, Energie
    Sprache: Englisch
    Materialart: workingpaper , doc-type:workingPaper
    Format: application/pdf
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  • 9
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    In:  EPIC3Aquaculture Economics and Management 14(4):, pp. 1365-7305
    Publikationsdatum: 2019-07-17
    Repository-Name: EPIC Alfred Wegener Institut
    Materialart: Article , isiRev
    Format: application/pdf
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  • 10
    Publikationsdatum: 2019-07-17
    Repository-Name: EPIC Alfred Wegener Institut
    Materialart: PANGAEA Documentation , notRev
    Format: application/pdf
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