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  • Articles  (1,895)
  • 2010-2014  (1,895)
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  • Articles  (1,895)
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  • 1
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    miR-374a promotes cell proliferation, migration and invasion by targeting SRCIN1 in gastric cancer (2014)
    Elsevier
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    Publication Date: 2014-12-31
    Description: Publication date: Available online 29 December 2014 Source: FEBS Letters Author(s): Xinyun Xu , Weijun Wang , Ning Su , Xujun Zhu , Jun Yao , Wenchao Gao , Zhiqian Hu , Yanping Sun MicroRNAs (miRNAs) play a prominent role in Gastric cancer (GC) initiation and progression. In this study, we found that miR-374a expression was up-regulated in human GC cell lines and tissues. Inhibition of miR-374a suppressed GC cell proliferation, migration and invasion in vitro and slowed tumor growth in vivo . SRC kinase signaling inhibitor 1 (SRCIN1) was identified as a direct target of miR-374a. Silencing of SRCIN1 significantly enhanced cell proliferation, migration and invasion, whereas SRCIN1 reintroduction partially abrogated the oncogenic effects of miR-374a. Taken together, these findings suggest that miR-374a functions as a candidate oncogene in GC by directly targeting SRCIN1. miR-374a may therefore be useful as a promising therapeutic target for malignant GC.
    Print ISSN: 0014-5793
    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
    Published by Elsevier
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  • 2
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    MiR-10a and miR-181c regulate collagen type I generation in hypertrophic scars by targeting PAI-1 and uPA (2014)
    Elsevier
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    Publication Date: 2014-12-31
    Description: Publication date: Available online 29 December 2014 Source: FEBS Letters Author(s): Chao Li , Hua-Yu Zhu , Wen-Dong Bai , Lin-Lin Su , Jia-Qi Liu , Wei-Xia Cai , Bin Zhao , Jian-Xin Gao , Shi-Chao Han , Jun Li , Da-Hai Hu Urokinase type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) have been proposed to play key roles in extracellular matrix (ECM) deposition in hypertrophic scars (HS). Here, we found that in HS fibroblasts (HFs) miR-181c and miR-10a were differentially-expressed and targeted uPA and PAI-1, respectively. The production of Type 1 collagen (Col1) was inhibited by miR-181c knockdown or miR-10a overexpression in HFs, and this resulted in increased levels of metalloproteinase 1 (MMP1). These results suggest that the miR-181c–uPA and miR-10a–PAI-1 regulatory pathways have an integral role in HS pathogenesis.
    Print ISSN: 0014-5793
    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
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  • 3
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    Divergent signalling pathways regulate lipopolysaccharide-induced eRNA expression in human monocytic THP1 cells (2014)
    Elsevier
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    Publication Date: 2014-12-31
    Description: Publication date: Available online 29 December 2014 Source: FEBS Letters Author(s): James A. Heward , Benoit T. Roux , Mark A. Lindsay Recent studies have indicated that non-coding RNAs transcribed from enhancer regions are important regulators of enhancer function and gene expression. In this report, we have characterised the expression of six enhancer RNAs (eRNAs) induced in human monocytic THP1 cells following activation of the innate immune response in response to lipopolysaccharide (LPS). Specifically, we have demonstrated that LPS-induced expression of individual eRNAs is mediated through divergent intracellular signalling pathways that includes NF-κB and the mitogen activated protein kinases, extracellular regulated kinase-1/2 and p38.
    Print ISSN: 0014-5793
    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
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  • 4
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    Interaction of Bordetella adenylate cyclase toxin with complement receptor 3 involves multivalent glycan binding (2014)
    Elsevier
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    Publication Date: 2014-12-31
    Description: Publication date: Available online 29 December 2014 Source: FEBS Letters Author(s): Shakir Hasan , Adriana Osickova , Ladislav Bumba , Petr Novák , Peter Sebo , Radim Osicka The interaction of Bordetella pertussis adenylate cyclase toxin (CyaA) with complement receptor 3 (CR3, CD11b/CD18) involves N-linked oligosaccharide chains. To investigate the relative importance of the individual N-glycans of CR3 for the toxin activity, the asparagine residues of the consensus N-glycosylation sites of CR3 were substituted with glutamine residues that cannot be glycosylated. Examination of the CR3 mutant variants and mass spectrometry analysis of the N-glycosylation pattern of CR3 revealed that N-glycans located in the C-terminal part of the CD11b subunit are involved in binding and cytotoxic activity of CyaA. We suggest that these N-glycans form a defined clustered saccharide patch that enables multivalent contact of CR3 with CyaA, enhancing both affinity and specificity of the integrin-toxin interaction.
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    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
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  • 5
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    K153R polymorphism in myostatin gene increases the rate of promyostatin activation by furin (2014)
    Elsevier
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    Publication Date: 2014-12-27
    Description: Publication date: Available online 25 December 2014 Source: FEBS Letters Author(s): György Szláma , Mária Trexler , László Buday , László Patthy Recent studies demonstrated an association between the K153R polymorphism in the myostatin gene with extreme longevity, lower muscle strength and obesity but the molecular basis of these associations has not been clarified. Here, we show that the K153R mutation significantly increases the rate of proteolysis of promyostatin by furin, but has no effect on the activity of the latent complex or the cleavage of the latent complex by bone morphogenetic protein 1 (BMP-1). The increased rate of activation of K153R mutant promyostatin may explain why this polymorphism is associated with obesity, lower muscle strength and extension of lifespan.
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    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
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  • 6
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    Uncapped 5’ ends of mRNAs targeted by cytoplasmic capping map to the vicinity of downstream CAGE tags (2014)
    Elsevier
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    Publication Date: 2014-12-26
    Description: Publication date: Available online 23 December 2014 Source: FEBS Letters Author(s): Daniel L. Kiss , Kenji Oman , Ralf Bundschuh , Daniel R. Schoenberg In mammalian transcriptomes approximately 25% of 5’ ends determined by Capped Analysis of Gene Expression (CAGE) map to locations within spliced exons. The current study sought to determine if the cytoplasmic capping complex participates in generating these downstream CAGE tags. 5’-RACE was used to amplify the uncapped ends of target transcripts that accumulate when cytoplasmic capping is blocked. Sequencing of these RACE products mapped the positions of uncapped ends either exactly to or just downstream of archived CAGE tags. These findings support a role for cytoplasmic capping in generating the downstream capped ends identified by CAGE.
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    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
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  • 7
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    Effects of detyrosinated tubulin on Na+,K+-atpase activity and erythrocyte function in hypertensive subjects (2014)
    Elsevier
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    Publication Date: 2014-12-26
    Description: Publication date: Available online 23 December 2014 Source: FEBS Letters Author(s): Marina R. Amaiden , Verónica S. Santander , Noelia E. Monesterolo , Ayelen D. Nigra , Juan F. Rivelli , Alexis N. Campetelli , Juan Pie , Cesar H. Casale Formation of tubulin/Na + ,K + -ATPase (NKA) complex in erythrocytes of hypertensive subjects results in a 50% reduction in NKA activity. We demonstrate here that detyrosinated tubulin, which is increased in hypertensive erythrocytes membranes, enhances the inhibitory effect of acetylated tubulin on NKA activity. Moreover, we report a reduced content and activity of the enzyme tubulin tyrosine ligase in erythrocytes of hypertensive subjects. Such alterations are related to changes in erythrocyte deformability. Our findings indicate that the detyrosination/tyrosination cycle of tubulin is important in regulation of NKA activity, and that abnormalities in this cycle are involved in hypertension development.
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    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
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  • 8
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    Wilms’ tumor 1 enhances Cisplatin-resistance of advanced NSCLC (2014)
    Elsevier
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    Publication Date: 2014-12-26
    Description: Publication date: 20 December 2014 Source: FEBS Letters, Volume 588, Issue 24 Author(s): Chen Wu , Yonggong Wang , Yang Xia , Shaohua He , Zhiqiang Wang , Yijiang Chen , Changping Wu , Yongqian Shu , Jingting Jiang Wilms’ tumor 1 ( WT1 ) is an oncogene that has been correlated with tumor progression, bad prognosis and chemo-resistance in Non-Small-Cell lung cancer (NSCLC). Here, we found that WT1 expression is significantly higher in NSCLCs than in benign controls, and that Cisplatin-resistant patients display a notable increase in WT1 expression following relapse. In vitro, WT1 levels were associated with the IC50 of NSCLC cells and increased along with treatment time and dose of Cisplatin. Furthermore, WT1 enhanced Major Vault Protein ( MVP ) transcription via binding to its promoter. Therefore, WT1 may be a potential therapeutic target for solving resistance.
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    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
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  • 9
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    Enzyme processivity changes with the extent of recalcitrant polysaccharide degradation (2014)
    Elsevier
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    Publication Date: 2014-12-26
    Description: Publication date: 20 December 2014 Source: FEBS Letters, Volume 588, Issue 24 Author(s): Anne Grethe Hamre , Silje Benedicte Lorentzen , Priit Väljamäe , Morten Sørlie Glycoside hydrolases depolymerize polysaccharides. They can subtract single carbohydrate chains from polymer crystals and cleave glycosidic bonds without dissociating from the substrate after each catalytic event. This processivity is thought to conserve energy during polysaccharide degradation. Herein, we compare the processivity of components of the chitinolytic machinery of Serratia marcescens . The two processive chitinases ChiA and ChiB, the ChiB-W97A mutant, and the endochitinase ChiC were analyzed for the extent of degradation of three different chitin substrates. Moreover, enzyme processivity was assessed on the basis of the [(GlcNAc)2]/[GlcNAc] product ratio. The results show that the apparent processivity (Papp) greatly diminishes with the extent of degradation and confirm the hypothesis that Papp is limited by the length of obstacle free path on the substrate.
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    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
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  • 10
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    Secondary conformational conversion is involved in glycosaminoglycans-mediated cellular uptake of the cationic cell-penetrating peptide PACAP (2014)
    Elsevier
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    Publication Date: 2014-12-26
    Description: Publication date: 20 December 2014 Source: FEBS Letters, Volume 588, Issue 24 Author(s): Armelle Tchoumi Neree , Phuong Trang Nguyen , David Chatenet , Alain Fournier , Steve Bourgault Glycosaminoglycans (GAGs) contribute to the cellular uptake of cationic cell-penetrating peptides (CPPs). However, molecular details about the contributions of GAGs in CPP internalization remain unclear. In this study, we examined the cellular uptake mechanism of the arginine-rich CPP pituitary adenylate-cyclase-activating polypeptide (PACAP). We observed that the uptake efficacy of PACAP is dependent on the expression of cell surface GAGs. As the binding of PACAP to sulfated GAGs induced a random coil-to-α-helix conformational conversion, we investigated the role of the helical formation in PACAP internalization. Whereas this secondary structure was not crucial for efficient internalization in GAGs-deficient cells, PACAP α-helix was essential for GAGs-dependent uptake.
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    Topics: Biology , Chemistry and Pharmacology , Physics
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