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  • 2010-2014  (1,895)
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  • 1
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    miR-374a promotes cell proliferation, migration and invasion by targeting SRCIN1 in gastric cancer (2014)
    Elsevier
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    Publication Date: 2014-12-31
    Description: Publication date: Available online 29 December 2014 Source: FEBS Letters Author(s): Xinyun Xu , Weijun Wang , Ning Su , Xujun Zhu , Jun Yao , Wenchao Gao , Zhiqian Hu , Yanping Sun MicroRNAs (miRNAs) play a prominent role in Gastric cancer (GC) initiation and progression. In this study, we found that miR-374a expression was up-regulated in human GC cell lines and tissues. Inhibition of miR-374a suppressed GC cell proliferation, migration and invasion in vitro and slowed tumor growth in vivo . SRC kinase signaling inhibitor 1 (SRCIN1) was identified as a direct target of miR-374a. Silencing of SRCIN1 significantly enhanced cell proliferation, migration and invasion, whereas SRCIN1 reintroduction partially abrogated the oncogenic effects of miR-374a. Taken together, these findings suggest that miR-374a functions as a candidate oncogene in GC by directly targeting SRCIN1. miR-374a may therefore be useful as a promising therapeutic target for malignant GC.
    Print ISSN: 0014-5793
    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
    Published by Elsevier
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  • 2
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    MiR-10a and miR-181c regulate collagen type I generation in hypertrophic scars by targeting PAI-1 and uPA (2014)
    Elsevier
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    Publication Date: 2014-12-31
    Description: Publication date: Available online 29 December 2014 Source: FEBS Letters Author(s): Chao Li , Hua-Yu Zhu , Wen-Dong Bai , Lin-Lin Su , Jia-Qi Liu , Wei-Xia Cai , Bin Zhao , Jian-Xin Gao , Shi-Chao Han , Jun Li , Da-Hai Hu Urokinase type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) have been proposed to play key roles in extracellular matrix (ECM) deposition in hypertrophic scars (HS). Here, we found that in HS fibroblasts (HFs) miR-181c and miR-10a were differentially-expressed and targeted uPA and PAI-1, respectively. The production of Type 1 collagen (Col1) was inhibited by miR-181c knockdown or miR-10a overexpression in HFs, and this resulted in increased levels of metalloproteinase 1 (MMP1). These results suggest that the miR-181c–uPA and miR-10a–PAI-1 regulatory pathways have an integral role in HS pathogenesis.
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    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
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  • 3
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    Interaction of Bordetella adenylate cyclase toxin with complement receptor 3 involves multivalent glycan binding (2014)
    Elsevier
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    Publication Date: 2014-12-31
    Description: Publication date: Available online 29 December 2014 Source: FEBS Letters Author(s): Shakir Hasan , Adriana Osickova , Ladislav Bumba , Petr Novák , Peter Sebo , Radim Osicka The interaction of Bordetella pertussis adenylate cyclase toxin (CyaA) with complement receptor 3 (CR3, CD11b/CD18) involves N-linked oligosaccharide chains. To investigate the relative importance of the individual N-glycans of CR3 for the toxin activity, the asparagine residues of the consensus N-glycosylation sites of CR3 were substituted with glutamine residues that cannot be glycosylated. Examination of the CR3 mutant variants and mass spectrometry analysis of the N-glycosylation pattern of CR3 revealed that N-glycans located in the C-terminal part of the CD11b subunit are involved in binding and cytotoxic activity of CyaA. We suggest that these N-glycans form a defined clustered saccharide patch that enables multivalent contact of CR3 with CyaA, enhancing both affinity and specificity of the integrin-toxin interaction.
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    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
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  • 4
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    Divergent signalling pathways regulate lipopolysaccharide-induced eRNA expression in human monocytic THP1 cells (2014)
    Elsevier
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    Publication Date: 2014-12-31
    Description: Publication date: Available online 29 December 2014 Source: FEBS Letters Author(s): James A. Heward , Benoit T. Roux , Mark A. Lindsay Recent studies have indicated that non-coding RNAs transcribed from enhancer regions are important regulators of enhancer function and gene expression. In this report, we have characterised the expression of six enhancer RNAs (eRNAs) induced in human monocytic THP1 cells following activation of the innate immune response in response to lipopolysaccharide (LPS). Specifically, we have demonstrated that LPS-induced expression of individual eRNAs is mediated through divergent intracellular signalling pathways that includes NF-κB and the mitogen activated protein kinases, extracellular regulated kinase-1/2 and p38.
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    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
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  • 5
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    K153R polymorphism in myostatin gene increases the rate of promyostatin activation by furin (2014)
    Elsevier
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    Publication Date: 2014-12-27
    Description: Publication date: Available online 25 December 2014 Source: FEBS Letters Author(s): György Szláma , Mária Trexler , László Buday , László Patthy Recent studies demonstrated an association between the K153R polymorphism in the myostatin gene with extreme longevity, lower muscle strength and obesity but the molecular basis of these associations has not been clarified. Here, we show that the K153R mutation significantly increases the rate of proteolysis of promyostatin by furin, but has no effect on the activity of the latent complex or the cleavage of the latent complex by bone morphogenetic protein 1 (BMP-1). The increased rate of activation of K153R mutant promyostatin may explain why this polymorphism is associated with obesity, lower muscle strength and extension of lifespan.
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    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
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  • 6
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    Botulinum neurotoxin homologs in non-Clostridium species (2014)
    Elsevier
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    Publication Date: 2014-12-26
    Description: Publication date: Available online 23 December 2014 Source: FEBS Letters Author(s): Michael J. Mansfield , Jeremy B. Adams , Andrew C. Doxey Clostridial neurotoxins (CNTs) are the deadliest toxins known and the causative agents of botulism and tetanus. Despite their structural and functional complexity, no CNT homologs are currently known outside Clostridium . Here, we report the first homologs of Clostridium CNTs within the genome of the rice fermentation organism Weissella oryzae SG25. One gene in W. oryzae S25 encodes a protein with a four-domain architecture and HExxH protease motif common to botulinum neurotoxins. An adjacent gene with partial similarity to CNTs is also present, and both genes seem to have been laterally transferred into the W. oryzae genome from an unknown source. Identification of mobile, CNT-related genes outside of Clostridium has implications for our understanding of the evolution of this important toxin family.
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    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
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  • 7
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    Zinc finger protein ZBTB20 promotes cell proliferation in non-small cell lung cancer through repression of FoxO1 (2014)
    Elsevier
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    Publication Date: 2014-12-26
    Description: Publication date: 20 December 2014 Source: FEBS Letters, Volume 588, Issue 24 Author(s): Jun-gang Zhao , Kai-ming Ren , Jun Tang In the present study, we found that ZBTB20, a member of the POK (POZ and Krüppel) family of transcriptional repressors, was significantly up-regulated in lung cancer tissues, compared with adjacent normal tissues. Our in vitro studies further found that ZBTB20 overexpression promoted, while its inhibition using small interfering RNA suppressed cell proliferation. Consistently, key regulators in cell-cycle progression, such as Cyclin D1, Cyclin E, P21 and P27, were also regulated by ZBTB20. At the molecular level, we further revealed that FoxO1, a tumor suppressor in multiple human cancers, was transcriptionally repressed by ZBTB20. Therefore, our results highlight an important role for ZBTB20 in controlling NSCLC development, which might be helpful to identify potential therapeutic targets for its treatment.
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    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
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  • 8
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    Low-intensity pulsed ultrasound-induced ATP increases bone formation via the P2X7 receptor in osteoblast-like cells (2014)
    Elsevier
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    Publication Date: 2014-12-26
    Description: Publication date: Available online 24 December 2014 Source: FEBS Letters Author(s): Soichiro Manaka , Natsuko Tanabe , Taro Kariya , Masako Naito , Tadahiro Takayama , Mayu Nagao , Di Liu , Koichi Ito , Masao Maeno , Naoto Suzuki , Masashi Miyazaki Low-intensity pulsed ultrasound (LIPUS) is used for bone healing in orthopedics and dentistry. It has been shown that LIPUS induces the secretion of extracellular adenosine triphosphate (ATP), a key mediator of osteoblast response to mechanical stimuli. However, the detailed mechanism of LIPUS-induced osteogenesis has been elusive. In this study, we investigated the role of the P2X7 receptor in LIPUS-induced osteogenesis. LIPUS induced the release of extracellular ATP, differentiation of osteoblasts and osteogenesis via the P2X7 receptor, without affecting the activity of alkaline phosphatase (ALPase). These results suggest that LIPUS-induced extracellular ATP promotes bone formation via the osteoblast P2X7 receptor independently of ALPase.
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    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
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  • 9
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    Revisiting the mechanism of activation of cyclic AMP Receptor Protein (CRP) by cAMP in Escherichia coli: Lessons from a subunit-crosslinked form of CRP (2014)
    Elsevier
    Details
    Publication Date: 2014-12-26
    Description: Publication date: Available online 23 December 2014 Source: FEBS Letters Author(s): Abinit Saha , Jayanta Mukhopadhyay , Ajit Bikram Datta , Pradeep Parrack Cyclic AMP receptor protein (CRP), the global transcription regulator in prokaryotes, is active only as a cAMP–CRP complex. Binding of cAMP changes the conformation of CRP, transforming it from a transcriptionally ‘inactive’ to an ‘active’ molecule. These conformers are also characterized by distinct biochemical properties including the ability to form an S–S crosslink between the C178 residues of its two monomeric subunits. We studied a CRP variant (CRP cl ), in which the subunits are crosslinked. We demonstrate that CRP cl can activate transcription even in the absence of cAMP. Implications of these results on the crystallographically-determined structure of cAMP-CRP are discussed.
    Print ISSN: 0014-5793
    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
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  • 10
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    Chemical activation of the cyanobacterial orange carotenoid protein (2014)
    Elsevier
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    Publication Date: 2014-12-26
    Description: Publication date: 20 December 2014 Source: FEBS Letters, Volume 588, Issue 24 Author(s): Jeremy D. King , Haijun Liu , Guannan He , Gregory S. Orf , Robert E. Blankenship The effects of the Hofmeister series of ions on the activation of the orange carotenoid protein (OCP) from the inactive orange form to the active red form were tested. Kosmotropes led to lower OCP activation, whereas chaotropes led to greater OCP activation. Concentrations of thiocyanate exceeding 1.5 M dark activate the orange carotenoid protein to its red form. This chemically activated OCP was studied by UV–vis and circular dichroism spectroscopies. The chemically-activated OCP quenches the fluorescence of phycobilisomes in vitro, to a level comparable to that of the light-activated OCP.
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    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
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