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  • 1
    Keywords: Biology -- Research. ; Life sciences. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (546 pages)
    Edition: 1st ed.
    ISBN: 9780309571098
    DDC: 570
    Language: English
    Note: The Life Sciences -- Copyright -- PREFACE -- CONTENTS -- MAJOR CONCLUSIONS AND RECOMMENDATIONS -- PROLOGUE -- RECOMMENDATIONS -- Population Problems -- The Environment -- Health -- Agriculture -- The Academic Endeavor in the Life Sciences -- INSTITUTIONAL SUPPORT PROGRAMS -- GRADUATE EDUCATION IN THE LIFE SCIENCES -- STIPENDS -- CURRICULA -- MEDICAL STUDENTS -- TECHNICAL ASSISTANTS -- POSTDOCTORAL EDUCATION -- RESEARCH SUPPORT -- FEDERAL RESEARCH-SUPPORTING AGENCIES -- SPECIALIZED FACILITIES -- INSTRUMENTS -- COMPUTERS -- LABORATORIES -- Museums -- Marine Biology Stations -- Biological Information -- CHAPTER ONE FRONTIERS OF BIOLOGY -- THE LANGUAGE OF LIFE -- The Genetic Material -- PROTEIN SYNTHESIS -- THE LIFE AND TIMES OF A CELL -- The Energy for Cell Work -- PHOTOSYNTHESIS -- Metabolism -- METABOLIC PATHWAYS -- METABOLIC CONTROLS -- ACTIVE TRANSPORT -- ENZYMES -- SUBCELLULAR ORGANELLES -- Cell Division -- DEVELOPMENT OF AN ORGANISM -- Development of the Nervous System -- Plant Embryogenesis -- Animal Viruses -- FORM AND FUNCTION -- Muscular Contraction -- THE CONSTANCY OF THE Milieu Interieur -- Endocrines -- PLANT AND INSECT HORMONES -- THE NERVOUS SYSTEM -- The Neuron -- SIGNALING IN NEURONS-THE TRANSFER OF INFORMATION -- INITIATION OF IMPULSE ACTIVITY AT SENSE ORGANS -- The Central Nervous System -- SMALL BRAINS -- LARGER BRAINS -- INTERCALATED SYSTEMS: HOMEOSTATIC REGULATION -- BEHAVIOR -- Evolution, Inheritance, and the Development of Behavior -- Physiological Analysis of Behavior -- ORIENTATION AND HOMING -- Learning and Memory -- ECOLOGY -- Some Areas of Ecological Research -- ENVIRONMENTAL CHALLENGES TO INDIVIDUAL ORGANISMS -- THE ABUNDANCE OF LIVING THINGS -- SPECIES INTERACTIONS -- ENERGY FLOW IN ECOSYSTEMS -- STABILITY AND DIVERSITY -- THE ORIGIN OF LIFE -- HEREDITY AND EVOLUTION -- Population Genetics-An Extension of Mendelism. , Cytogenetics -- HUMAN CYTOGENETICS -- Polymorphism -- Some Recent Accomplishments -- THE DIVERSITY OF LIFE -- What Is a Species? -- Origins of Species -- Origin of Higher Groups -- Extinction -- Diversity and the Conceptual Framework of Biology -- CHAPTER TWO BIOLOGY IN THE SERVICE OF MAN -- BIOLOGICAL RESEARCH AND MEDICAL PRACTICE -- The National Health -- Diagnosis, Disease, and Drugs -- SULFONAMIDES AND ANTIMETABOLITES -- ANTIBIOTICS -- VIRAL DISEASES -- CANCER THERAPY -- GOUT -- GENETIC DISEASES -- THE IMMUNE SYSTEM -- TISSUE TRANSPLANTATION -- CARDIAC DISORDERS -- Population Control -- The Early and Latter Years of Life -- ON FEEDING MAN -- Crop Yields -- GENETICS AND AGRICULTURAL PRACTICE -- Agricultural Practice -- Animal Science -- MAN AND HIS ENVIRONMENT -- Water Supplies -- Air -- Food and Drugs -- RENEWABLE RESOURCES -- Role of Science in the Management of Renewable Resources -- Principles of Management -- Environmental Management -- AGRICULTURE -- FORESTRY -- FISHERIES -- WILDLIFE -- RECREATION -- URBAN AND RURAL DEVELOPMENT -- INDUSTRIAL TECHNOLOGY -- Pharmaceuticals -- Food -- Pesticides -- Fermentation Industry -- Instrumentation -- CHAPTER THREE THE WORLD OF BIOLOGICAL RESEARCH -- WHERE LIFE SCIENTISTS WORK -- MOBILITY OF LIFE SCIENTISTS -- PREVIOUS EDUCATION OF WORKING LIFE SCIENTISTS -- POSTDOCTORAL TRAINING -- EDUCATIONAL LIMITATIONS -- WITH WHAT MATERIALS DO LIFE SCIENTISTS WORK? -- WITH WHAT SPECIES DO LIFE SCIENTISTS WORK? -- WHAT FACILITIES AND TOOLS DO LIFE SCIENTISTS USE? -- Specialized Biological Research Facilities -- Major Instruments -- THE RESEARCH GROUP -- WHAT DO LIFE SCIENTISTS DO? -- FINANCIAL SUPPORT OF RESEARCH IN THE LIFE SCIENCES -- Utilization of Research Grants -- Research Support as a Function of the Investigator's Age -- RESEARCH INSTITUTES -- NATURAL HISTORY MUSEUMS -- BIOLOGICAL DISCIPLINES. , CHAPTER FOUR THE ACADEMIC ENDEAVOR IN THE LIFE SCIENCES -- ACADEMIC DEPARTMENTS -- The Life Sciences Faculty -- UNFILLED FACULTY POSITIONS -- Graduate Education in the Life Sciences -- CAPACITY OF THE CURRENT GRADUATE EDUCATION SYSTEM -- STUDENT STIPENDS -- Postdoctoral Fellows -- FINANCING POSTDOCTORAL EDUCATION -- FOREIGN POSTDOCTORALS -- FOREIGN INTERNS AND RESIDENTS -- Laboratory Space -- The Tools of Biological Research -- SPECIALIZED RESEARCH FACILITIES -- UTILIZATION OF RESEARCH INSTRUMENTS -- MEDICAL SCHOOLS AS RESEARCH AND EDUCATIONAL ENTERPRISES -- Medical Students in Research -- AGRICULTURAL SCHOOLS AS RESEARCH AND EDUCATIONAL ENTERPRISES -- FINANCING ACADEMIC RESEARCH IN THE LIFE SCIENCES -- Faculty Salaries -- CHAPTER FIVE REQUIREMENTS FOR THE FUTURE OF THE ACADEMIC ENDEAVOR IN THE LIFE SCIENCES -- INDIVIDUAL SCIENTISTS -- Academic Scientists -- Nonacademic Scientists -- Personal Constraints on Research -- Specialized Facilities -- Instrumentation -- DEPARTMENT CHAIRMEN -- Specialized Facilities -- Instrumentation -- Improvement and Expansion of the Academic Research Endeavor -- Expansion of the Graduate Education Endeavor -- NATIONAL CONSIDERATIONS -- Museums -- In Conclusion -- CHAPTER SIX EDUCATION IN BIOLOGY -- ELEMENTARY AND SECONDARY EDUCATION -- UNIVERSITY EDUCATION -- The Setting -- Undergraduate Curricula -- The Teaching of Biology -- TEACHING AS AN ACTIVITY -- REWARDS FOR TEACHING -- NEW METHODS OF TEACHING -- THE TRAINING AND RETRAINING OF TEACHERS -- BIOLOGY AND LIBERAL EDUCATION -- Research Training: Graduate Education in the Life Sciences -- THE INSTITUTIONAL SYSTEM: FUNCTIONS AND DIVERSITY -- THE STUDENT POPULATION: SIZE, ATTRITION, LOCATION -- FINANCIAL SUPPORT OF THE GRADUATE STUDENT AND HIS EDUCATION -- THE GRADUATE PROGRAM -- THE FUTURE OF GRADUATE PROGRAMS -- CHAPTER SEVEN DIGITAL COMPUTERS IN THE LIFE SCIENCES. , GENERAL FACTS ABOUT COMPUTER USAGE -- THE STATE OF COMPUTER APPLICATION IN THE LIFE SCIENCES -- Extent of Use -- Types of Use -- Computer Use in Research Areas of the Life Sciences -- The Growth of Computer Usage -- Institutional Arrangements for Computer Use -- Funding of Computer Use -- CONCLUSIONS AND RECOMMENDATIONS -- CHAPTER EIGHT COMMUNICATION IN THE LIFE SCIENCES -- SPECIAL PROBLEMS IN HANDLING BIOLOGICAL INFORMATION -- USERS OF BIOLOGICAL INFORMATION -- INFORMAL INFORMATION TRANSFER -- Meetings -- Informal Publications and Correspondence -- PRIMARY PUBLICATION -- The Journal -- New Forms of Primary Publication -- Future Forms of Primary Publication -- The International Literature -- REVIEW ARTICLES AND DATA COMPILATION -- SECONDARY INFORMATION SERVICES -- Functions and Desirable Characteristics of a Secondary Service -- SPECIALIZED INFORMATION CENTERS -- LIBRARIES -- LOOKING FORWARD -- CHAPTER NINE BIOLOGY AND THE FUTURE OF MAN -- THE NATURE OF MAN -- THE GREAT HAZARDS -- War -- Man and His Environment -- The Size of Human Populations -- FOOD PRODUCTION: THE SHORT-TERM PROBLEM -- POPULATION CONTROL: THE LONG-TERM PROBLEM -- Guarding the Genetic Quality of Man -- THE OPPORTUNITIES -- Biology and Medicine -- MOLECULAR DISEASES -- INFECTIOUS DISEASES -- TRANSPLANTATION AND ARTIFICIAL ORGANS -- THE ETHICS OF TERMINAL MEDICAL CARE -- GENETIC DISEASES -- REGENERATION -- THE DELIVERY OF MEDICAL CARE -- Early Environmental Influences -- Controlled Sex Determination -- Differential Fertility -- Selection and the Variability of Man -- APPENDIX A METHODOLOGY: SURVEY OF INDIVIDUAL LIFE SCIENTISTS -- POPULATION SELECTION -- DATA ANALYSIS: DEFINITIONS AND TABULATION CONSTRAINTS -- Definitions -- Constraints -- SUBCATEGORY LISTINGS REQUIRED TO ANSWER QUESTIONS 18 AND 19 -- VALIDITY OF THE RESPONDENT POPULATION. , APPENDIX B METHODOLOGY: SURVEY OF ACADEMIC LIFE SCIENCE DEPARTMENTS -- SOURCE OF DEPARTMENTAL MAILING LIST -- POPULATION SELECTION -- Definition of a Department -- Exclusion Criteria -- DATA ANALYSIS -- Definitions and Coding Restrictions -- SPECIAL DEFINITIONS -- PANELS AND CONTRIBUTORS -- PANELS OF THE COMMITTEE ON RESEARCH IN THE LIFE SCIENCES -- Origins of Life -- Molecular Biology -- The Materials of Life and Their Transformations -- Cellular and Subcellular Structure and Function -- Developmental Biology -- Function of Tissues and Organs -- Anatomical Sciences -- Structure and Function of the Nervous System -- Behavioral Biology -- Ecology -- Evolutionary Mechanisms and Population Biology -- The Diversity of Life -- Biological Science and the Production of Food and Fiber -- Biological Science and the Advancement of Medicine -- Human Development and Changes With Time -- Biology and Industrial Technology -- Biology and Education -- Biology and Renewable Resources -- Biology and the Future of Man -- The Role of Computers in the Life Sciences -- Environmental Health -- Biology and National Defense -- INDIVIDUAL CONTRIBUTORS TO LIFE SCIENCES STUDY -- COUNCIL ON BIOLOGICAL SCIENCES INFORMATION.
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  • 2
    Publication Date: 2014-11-11
    Description: Publication date: Available online 4 November 2014 Source: International Journal of Production Economics Author(s): Klaus Reinholdt Nyhuus Hansen , Martin Grunow Shorter product life cycles and the resulting increase in new product introductions boost the importance of product launch operations. In the pharmaceutical sector, product launch operations are of particular importance, as companies seek to reduce time-to-market to better exploit patent protection. Large volumes of product need to be ready to fill the downstream supply chain immediately at market launch. Building up the required inventory is, however, connected to several risks. In addition to the risk associated with the lack of demand information for a new product, there are several risks unique to the pharmaceutical sector. After approval by central authorities such as the FDA or EMA, a new drug still needs to receive market authorization, which is in most cases granted by some local authorities - in Europe, for example, by more than 30 national and regional bodies. The duration of these different market authorization processes as well as their outcomes (e.g. price and reimbursement levels, requirements of label or leaflet changes) are highly uncertain. We develop a two-stage stochastic model to support market launch preparation decisions. It trades off the costs of accepting these risks, for example by risk packaging before authorization, against the lost revenue caused by risk-averse operations. The model is applied to a case based on an empirical study. Our approach results in significant savings compared to current practices. We hereby provide an example of how quantitative methodology can provide valuable decision support for product launch operations, even when complex regulatory affairs need to be considered.
    Print ISSN: 0925-5273
    Electronic ISSN: 1873-7579
    Topics: Technology , Economics
    Published by Elsevier
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  • 3
    Publication Date: 2022-02-18
    Description: Based on the European Waste Framework Directive and the German Recycling Management Act of 01.06.2012 the objectives for a national waste prevention programme were defined. As main objective, according to art. 1 WFD, the "prevention or reduction of the disadvantageous impacts of waste generation and management on the human health and the environment" is recommended. Indicators for a quantitative and qualitative monitoring are derived for both, the individual measures as well as for a waste prevention programme.
    Keywords: ddc:320
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: English
    Type: report , doc-type:report
    Format: application/pdf
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  • 4
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie | Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2022-02-18
    Description: This report presents the findings and recommendations of the EMI case study undertaken as part of the Digital Europe project. Chapter 2 sets out the background to the case study; chapter 3 investigates the environmental impacts of digital music; and chapter 4 highlights the social impacts of digital music. Chapter 5 outlines future scenarios for the sector and chapter 6 draws recommendations for business and government.
    Keywords: ddc:600
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: English
    Type: report , doc-type:report
    Format: application/pdf
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  • 5
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    International Phycological Society
    In:  Phycologia, 52 (4, Supplement). p. 119.
    Publication Date: 2019-09-23
    Description: To evaluate the importance of anti-herbivore resistance for algal invasion success we compared resistance traits among specimens of the red macroalga Gracilaria vermiculophylla from six native populations in Korea and China and eight invasive populations in Europe and Mexico that were maintained under identical conditions in the laboratory. Herbivorous snails both from the native range (Littorina brevicula) and from the invaded range (Littorina littorea) consumed significantly less of seaweed specimens originating from non-native populations. Metabolome profiling revealed that this preference was correlated with an increased woundactivated production of deterring prostaglandins and hydroxyeicosatetraenoic acids. Thus, invasive populations of G. vermiculophylla are more strongly defended against challenge by herbivores and other biological enemies that cause local tissue or cell disruption and activate oxylipin production. Anthropogenic distribution of genotypes adapted to resist elevated feeding pressure probably contributed to the invasion success of this species.
    Type: Article , PeerReviewed
    Format: text
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  • 6
    Publication Date: 2019-09-23
    Description: Grazing by the isopod Idotea baltica induces chemical defenses in the brown seaweed Fucus vesiculosus. A combination of a 33 day induction experiment, feeding choice assays and functional genomic analyses was used to investigate temporal defense patterns and to correlate changes in palatability to changes in gene expression. Despite permanent grazing, seaweed palatability varied over time. Controls were significantly more consumed than grazed pieces only after 18 and 27 days of grazing. Relative to controls, 562/402 genes were up-/down-regulated in seaweed pieces that were grazed for 18 days, i.e. when defense induction was detected. Reprogramming of the regulative expression orchestra (translation, transcription), up-regulation of genes involved in lipid and carbohydrate metabolism, intracellular trafficking, defense and stress response, as well as downregulation of photosynthesis was found in grazed seaweed. These findings indicate short-term temporal variation in defenses and that modified gene expression patterns arise at the same time when grazed seaweed pieces show reduced palatability. Several genes with putative defensive functions and cellular processes potentially involved in defence, such as reallocation of resources from primary to secondary metabolism, were revealed
    Type: Article , PeerReviewed
    Format: text
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  • 7
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    DCE – Danish Centre for Environment and Energy, Aarhus Univ.
    Publication Date: 2020-02-12
    Description: This book is about management of arctic and northern alpine research stations. It has been produced by a group of station managers participating in the EU 7th Framework Programme Infrastructure project called INTERACT. With this book we want to share the knowledge and experiences we have gained from managing very different research stations in very different environmental and climatic settings. The target audience for the book is mainly managers of research stations in arctic and alpine areas, but we hope that it will also be useful for others involved in science coordination and logistics, e.g. research institutions, chief scientists and expedition planners. The book has been produced mainly based on input from practising station managers being part of ‘INTERACT Station Managers’ Forum (SMF), a forum established to provide a platform for exchange of information between station managers and other participants within INTERACT, and to collect and disseminate knowledge embedded within the network. The scope of this book is to identify and describe best practices and key considerations of relevance to station management under arctic and alpine conditions. As research stations operate under very different legal regimes, financial conditions, environmental and climatic conditions, as well as remoteness, it is not possible to identify specific best practices that fit all stations. Instead, we have described key issues that should be considered and addressed by station management, and supplemented this with examples of good practices from stations operating under different conditions (e.g. different climate, remoteness or size).
    Language: English
    Type: info:eu-repo/semantics/book
    Format: application/pdf
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  • 8
    Publication Date: 2017-04-04
    Description: Population growth, urbanization and global climate change have increased urban and agricultural water demands, stressing aquifer systems where groundwater is a source of water supply. The availability and utility of groundwater may further be threatened by factors stressing the quality of groundwater, such as industrial and domestic wastes and agricultural intensification. Consequences include, for example, over-allocation of groundwater, groundwater overdraft, declining well yields and land subsidence; degraded groundwater quality due to mobilization of natural pollutants (arsenic), salt contamination caused by seawater intrusion; increased demand for conjunctively used surface water, and resulting conflicts with junior users; and streamflow capture and resulting damage to ecosystems. These consequences may occur incrementally and inequitably across an aquifer. Natural environmental problems can further complicate use of groundwater and increase strain on the aquifer system; for example, underground structures, geothermal heating (such as heat islands), and geochemical evolution (such as karst formation, excessive salinity, acidity, fluoride, radioactivity, hardness, or turbidity). To address this issue, a joint symposium on the Trends and Sustainability of Groundwater in Highly Stressed Aquifers was held during the 8th Scientific Assembly of the International Association of Hydrological Sciences, IAHS, and the 37th Congress of the International Association of Hydrogeology, IAH, in Hyderabad, India, September 2009. The symposium was organized by the IAHS International Commission on Groundwater (ICGW), supported IAH and by the IAHS International Commission on Water Quality (ICWQ). This symposium brought together scientists, including modellers, geochemists and hydro-geologists, with water supply managers and policy makers to discuss scientific and management ideas and approaches for improving the sustainability of highly stressed aquifers. The importance of this topic was reflected in the large number of contributions to the symposium. Selected papers from this symposium have been compiled in this volume. The editors gratefully acknowledge the assistance of the reviewers who made valuable contributions to this volume. We thank Penny Perrins and Cate Gardner from IAHS Press for their professional approach and help with the processing of the manuscripts.
    Description: Published
    Description: V
    Description: open
    Keywords: goundwater ; 03. Hydrosphere::03.02. Hydrology::03.02.03. Groundwater processes
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: book chapter
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  • 9
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie | Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2022-02-18
    Keywords: ddc:600
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: English
    Type: workingpaper , doc-type:workingPaper
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  • 10
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    In:  EPIC3Aquaculture Economics and Management 14(4):, pp. 1365-7305
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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