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  • Articles  (1,895)
  • 2010-2014  (1,895)
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  • Articles  (1,895)
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  • 1
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    miR-374a promotes cell proliferation, migration and invasion by targeting SRCIN1 in gastric cancer (2014)
    Elsevier
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    Publication Date: 2014-12-31
    Description: Publication date: Available online 29 December 2014 Source: FEBS Letters Author(s): Xinyun Xu , Weijun Wang , Ning Su , Xujun Zhu , Jun Yao , Wenchao Gao , Zhiqian Hu , Yanping Sun MicroRNAs (miRNAs) play a prominent role in Gastric cancer (GC) initiation and progression. In this study, we found that miR-374a expression was up-regulated in human GC cell lines and tissues. Inhibition of miR-374a suppressed GC cell proliferation, migration and invasion in vitro and slowed tumor growth in vivo . SRC kinase signaling inhibitor 1 (SRCIN1) was identified as a direct target of miR-374a. Silencing of SRCIN1 significantly enhanced cell proliferation, migration and invasion, whereas SRCIN1 reintroduction partially abrogated the oncogenic effects of miR-374a. Taken together, these findings suggest that miR-374a functions as a candidate oncogene in GC by directly targeting SRCIN1. miR-374a may therefore be useful as a promising therapeutic target for malignant GC.
    Print ISSN: 0014-5793
    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
    Published by Elsevier
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  • 2
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    MiR-10a and miR-181c regulate collagen type I generation in hypertrophic scars by targeting PAI-1 and uPA (2014)
    Elsevier
    Details
    Publication Date: 2014-12-31
    Description: Publication date: Available online 29 December 2014 Source: FEBS Letters Author(s): Chao Li , Hua-Yu Zhu , Wen-Dong Bai , Lin-Lin Su , Jia-Qi Liu , Wei-Xia Cai , Bin Zhao , Jian-Xin Gao , Shi-Chao Han , Jun Li , Da-Hai Hu Urokinase type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) have been proposed to play key roles in extracellular matrix (ECM) deposition in hypertrophic scars (HS). Here, we found that in HS fibroblasts (HFs) miR-181c and miR-10a were differentially-expressed and targeted uPA and PAI-1, respectively. The production of Type 1 collagen (Col1) was inhibited by miR-181c knockdown or miR-10a overexpression in HFs, and this resulted in increased levels of metalloproteinase 1 (MMP1). These results suggest that the miR-181c–uPA and miR-10a–PAI-1 regulatory pathways have an integral role in HS pathogenesis.
    Print ISSN: 0014-5793
    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
    Published by Elsevier
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  • 3
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    Divergent signalling pathways regulate lipopolysaccharide-induced eRNA expression in human monocytic THP1 cells (2014)
    Elsevier
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    Publication Date: 2014-12-31
    Description: Publication date: Available online 29 December 2014 Source: FEBS Letters Author(s): James A. Heward , Benoit T. Roux , Mark A. Lindsay Recent studies have indicated that non-coding RNAs transcribed from enhancer regions are important regulators of enhancer function and gene expression. In this report, we have characterised the expression of six enhancer RNAs (eRNAs) induced in human monocytic THP1 cells following activation of the innate immune response in response to lipopolysaccharide (LPS). Specifically, we have demonstrated that LPS-induced expression of individual eRNAs is mediated through divergent intracellular signalling pathways that includes NF-κB and the mitogen activated protein kinases, extracellular regulated kinase-1/2 and p38.
    Print ISSN: 0014-5793
    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
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  • 4
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    Interaction of Bordetella adenylate cyclase toxin with complement receptor 3 involves multivalent glycan binding (2014)
    Elsevier
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    Publication Date: 2014-12-31
    Description: Publication date: Available online 29 December 2014 Source: FEBS Letters Author(s): Shakir Hasan , Adriana Osickova , Ladislav Bumba , Petr Novák , Peter Sebo , Radim Osicka The interaction of Bordetella pertussis adenylate cyclase toxin (CyaA) with complement receptor 3 (CR3, CD11b/CD18) involves N-linked oligosaccharide chains. To investigate the relative importance of the individual N-glycans of CR3 for the toxin activity, the asparagine residues of the consensus N-glycosylation sites of CR3 were substituted with glutamine residues that cannot be glycosylated. Examination of the CR3 mutant variants and mass spectrometry analysis of the N-glycosylation pattern of CR3 revealed that N-glycans located in the C-terminal part of the CD11b subunit are involved in binding and cytotoxic activity of CyaA. We suggest that these N-glycans form a defined clustered saccharide patch that enables multivalent contact of CR3 with CyaA, enhancing both affinity and specificity of the integrin-toxin interaction.
    Print ISSN: 0014-5793
    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
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  • 5
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    K153R polymorphism in myostatin gene increases the rate of promyostatin activation by furin (2014)
    Elsevier
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    Publication Date: 2014-12-27
    Description: Publication date: Available online 25 December 2014 Source: FEBS Letters Author(s): György Szláma , Mária Trexler , László Buday , László Patthy Recent studies demonstrated an association between the K153R polymorphism in the myostatin gene with extreme longevity, lower muscle strength and obesity but the molecular basis of these associations has not been clarified. Here, we show that the K153R mutation significantly increases the rate of proteolysis of promyostatin by furin, but has no effect on the activity of the latent complex or the cleavage of the latent complex by bone morphogenetic protein 1 (BMP-1). The increased rate of activation of K153R mutant promyostatin may explain why this polymorphism is associated with obesity, lower muscle strength and extension of lifespan.
    Print ISSN: 0014-5793
    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
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  • 6
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    Uncapped 5’ ends of mRNAs targeted by cytoplasmic capping map to the vicinity of downstream CAGE tags (2014)
    Elsevier
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    Publication Date: 2014-12-26
    Description: Publication date: Available online 23 December 2014 Source: FEBS Letters Author(s): Daniel L. Kiss , Kenji Oman , Ralf Bundschuh , Daniel R. Schoenberg In mammalian transcriptomes approximately 25% of 5’ ends determined by Capped Analysis of Gene Expression (CAGE) map to locations within spliced exons. The current study sought to determine if the cytoplasmic capping complex participates in generating these downstream CAGE tags. 5’-RACE was used to amplify the uncapped ends of target transcripts that accumulate when cytoplasmic capping is blocked. Sequencing of these RACE products mapped the positions of uncapped ends either exactly to or just downstream of archived CAGE tags. These findings support a role for cytoplasmic capping in generating the downstream capped ends identified by CAGE.
    Print ISSN: 0014-5793
    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
    Published by Elsevier
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  • 7
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    Low-intensity pulsed ultrasound-induced ATP increases bone formation via the P2X7 receptor in osteoblast-like cells (2014)
    Elsevier
    Details
    Publication Date: 2014-12-26
    Description: Publication date: Available online 24 December 2014 Source: FEBS Letters Author(s): Soichiro Manaka , Natsuko Tanabe , Taro Kariya , Masako Naito , Tadahiro Takayama , Mayu Nagao , Di Liu , Koichi Ito , Masao Maeno , Naoto Suzuki , Masashi Miyazaki Low-intensity pulsed ultrasound (LIPUS) is used for bone healing in orthopedics and dentistry. It has been shown that LIPUS induces the secretion of extracellular adenosine triphosphate (ATP), a key mediator of osteoblast response to mechanical stimuli. However, the detailed mechanism of LIPUS-induced osteogenesis has been elusive. In this study, we investigated the role of the P2X7 receptor in LIPUS-induced osteogenesis. LIPUS induced the release of extracellular ATP, differentiation of osteoblasts and osteogenesis via the P2X7 receptor, without affecting the activity of alkaline phosphatase (ALPase). These results suggest that LIPUS-induced extracellular ATP promotes bone formation via the osteoblast P2X7 receptor independently of ALPase.
    Print ISSN: 0014-5793
    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
    Published by Elsevier
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  • 8
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    MicroRNAs in the immune organs of chickens and ducks indicate divergence of immunity against H5N1 avian influenza (2014)
    Elsevier
    Details
    Publication Date: 2014-12-26
    Description: Publication date: Available online 23 December 2014 Source: FEBS Letters Author(s): Zezhong Li , Jinyu Zhang , Jiazi Su , Yinuo Liu , Jiang Guo , Yonghong Zhang , Chunyan Lu , Shenyang Xing , Yuntao Guan , Yanbing Li , Boxing Sun , Zhihui Zhao Chickens are susceptible to the highly pathogenic H5N1 strain of avian influenza virus (HPAIV), whereas ducks are not. Here, we used high-throughput sequencing to analyse the microRNA expression in the spleen, thymus and bursa of Fabricius of H5N1-HPAIV-infected and non-infected chickens and ducks.We annotated the genomic positions of duck microRNAs and we compared the microRNA repertoires of chickens and ducks. Our results showed that the microRNA expression patterns in the homologous immune organs of specific-pathogen-free (SPF) chickens and ducks diverge substantially. Moreover, there was larger divergence between the microRNA expression patterns in immune organs of HPAIV-infected chickens and HPAIV-infected ducks. Together, our results might help to elucidate the roles of microRNAs in the divergent immunity of chickens and ducks against H5N1-HPAIV.
    Print ISSN: 0014-5793
    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
    Published by Elsevier
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  • 9
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    Botulinum neurotoxin homologs in non-Clostridium species (2014)
    Elsevier
    Details
    Publication Date: 2014-12-26
    Description: Publication date: Available online 23 December 2014 Source: FEBS Letters Author(s): Michael J. Mansfield , Jeremy B. Adams , Andrew C. Doxey Clostridial neurotoxins (CNTs) are the deadliest toxins known and the causative agents of botulism and tetanus. Despite their structural and functional complexity, no CNT homologs are currently known outside Clostridium . Here, we report the first homologs of Clostridium CNTs within the genome of the rice fermentation organism Weissella oryzae SG25. One gene in W. oryzae S25 encodes a protein with a four-domain architecture and HExxH protease motif common to botulinum neurotoxins. An adjacent gene with partial similarity to CNTs is also present, and both genes seem to have been laterally transferred into the W. oryzae genome from an unknown source. Identification of mobile, CNT-related genes outside of Clostridium has implications for our understanding of the evolution of this important toxin family.
    Print ISSN: 0014-5793
    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
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  • 10
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    Effects of detyrosinated tubulin on Na+,K+-atpase activity and erythrocyte function in hypertensive subjects (2014)
    Elsevier
    Details
    Publication Date: 2014-12-26
    Description: Publication date: Available online 23 December 2014 Source: FEBS Letters Author(s): Marina R. Amaiden , Verónica S. Santander , Noelia E. Monesterolo , Ayelen D. Nigra , Juan F. Rivelli , Alexis N. Campetelli , Juan Pie , Cesar H. Casale Formation of tubulin/Na + ,K + -ATPase (NKA) complex in erythrocytes of hypertensive subjects results in a 50% reduction in NKA activity. We demonstrate here that detyrosinated tubulin, which is increased in hypertensive erythrocytes membranes, enhances the inhibitory effect of acetylated tubulin on NKA activity. Moreover, we report a reduced content and activity of the enzyme tubulin tyrosine ligase in erythrocytes of hypertensive subjects. Such alterations are related to changes in erythrocyte deformability. Our findings indicate that the detyrosination/tyrosination cycle of tubulin is important in regulation of NKA activity, and that abnormalities in this cycle are involved in hypertension development.
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    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
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