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  • 2015-2019  (2)
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  • 1
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    A long-term context (931–2005 C.E.) for rapid warming over Central Asia (2015)
    Details
    Publikationsdatum: 2022-05-25
    Beschreibung: Author Posting. © The Author(s), 2014. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution. The definitive version was published in Quaternary Science Reviews 121 (2015): 89-97, doi:10.1016/j.quascirev.2015.05.020.
    Beschreibung: Warming over Mongolia and adjacent Central Asia has been unusually rapid over the past few decades, particularly in the summer, with surface temperature anomalies higher than for much of the globe. With few temperature station records available in this remote region prior to the 1950s, paleoclimatic data must be used to understand annual-to-centennial scale climate variability, to local response to large-scale forcing mechanisms, and the significance of major features of the past millennium such as the Medieval Climate Anomaly (MCA) and Little Ice Age (LIA) both of which can vary globally. Here we use an extensive collection of living and subfossil wood samples from temperature-sensitive trees to produce a millennial-length, validated reconstruction of summer temperatures for Mongolia and Central Asia from 931 to 2005 CE. This tree-ring reconstruction shows general agreement with the MCA (warming) and LIA (cooling) trends, a significant volcanic signature, and warming in the 20th and 21st Century. Recent warming (2000-2005) exceeds that from any other time and is concurrent with, and likely exacerbated, the impact of extreme drought (1999-2002) that resulted in massive livestock loss across Mongolia.
    Beschreibung: This research was supported by the National Science Foundation under grants AGS-PRF #1137729, ATM0117442, and AGS0402474.
    Schlagwort(e): Mongolia ; Temperature ; Tree-ring ; Dendrochronology ; Reconstruction ; Global warming
    Repository-Name: Woods Hole Open Access Server
    Materialart: Preprint
    Format: application/pdf
    Standort Signatur Einschränkungen Verfügbarkeit
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    ARTIKEL (OA)
  • 2
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    Blood Pressure Control and Risk of Stroke or Systemic Embolism in Patients With Atrial Fibrillation: Results From the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) Trial [Stroke] (2015)
    American Heart Association (AHA)
    Details
    Publikationsdatum: 2015-12-24
    Beschreibung: Background Patients with atrial fibrillation (AF) and hypertension are at high risk for stroke. Previous studies have shown elevated risk of stroke in patients with AF who have a history of hypertension (regardless of blood pressure [BP] control) and in patients with elevated BP. We assessed the association of hypertension and BP control on clinical outcomes. Methods and Results In ARISTOTLE (n=18 201), BP was evaluated as history of hypertension requiring treatment and elevated BP (systolic ≥140 and/or diastolic ≥90 mm Hg) at study entry and any point during the trial. Hazard ratios (HRs) were derived from Cox proportional hazards models including BP as a time-dependent covariate. A total of 15 916 (87.5%) patients had a history of hypertension requiring treatment. In patients with elevated BP measurement at any point during the trial, the rate of stroke or systemic embolism was significantly higher (HR, 1.53; 95% confidence interval [CI], 1.25–1.86), as was hemorrhagic stroke (HR 1.85; 95% CI, 1.26–2.72) and ischemic stroke (HR, 1.50; 95% CI, 1.18–1.90). Rates of major bleeding were lower in patients with a history of hypertension (HR, 0.80; 95% CI, 0.66–0.98) and nonsignificantly lower in patients with elevated BP at study entry (HR, 0.89; 95% CI, 0.77–1.03). The benefit of apixaban versus warfarin on preventing stroke or systemic embolism was consistent among patients with and without a history of hypertension ( P interaction=0.27), BP control at baseline ( P interaction=0.43), and BP control during the trial ( P interaction=0.97). Conclusions High BP measurement at any point during the trial was independently associated with a substantially higher risk of stroke or systemic embolism. These results strongly support efforts to treat elevated BP as an important strategy to optimally lower risk of stroke in patients with AF. Clinical Trial Registration URL: https://ClinicalTrials.gov/ . Unique identifier: NCT00412984.
    Digitale ISSN: 2047-9980
    Thema: Medizin
    Publiziert von American Heart Association (AHA)
    Standort Signatur Einschränkungen Verfügbarkeit
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