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  • 1
    In: Biogeosciences, Katlenburg-Lindau [u.a.] : Copernicus, 2004, 5(2008), 5, Seite 1199-1213, 1726-4189
    In: volume:5
    In: year:2008
    In: number:5
    In: pages:1199-1213
    Beschreibung / Inhaltsverzeichnis: To enable an accurate estimate of total excess nitrogen (N) in the North Atlantic, a new tracer TNxs is defined, which includes the contribution of organic nutrients to the assessment of N:P stoichiometric anomalies. We measured the spatial distribution of TNxs within the subtropical North Atlantic using data from a trans-Atlantic section across 24.5° N occupied in 2004. We then employ three different approaches to infer rates of total excess nitrogen accumulation using pCFC-12 derived ventilation ages (a TNxs vertical integration, a one end-member and a two-end member mixing model). Despite some variability among the different methods the dissolved organic nutrient fraction always contributes to about half of the TNxs accumulation, which is in the order of 9.38±4.18×10 11 mol N y-1. We suggest that neglecting organic nutrients in stoichiometric balances of the marine N and P inventories can lead to systematic errors when estimating deviations of nitrogen excess or deficit relative to the Redfield ratio in the oceans. For the North Atlantic the inclusion of the organic fraction to the excess nitrogen pool leads to an upward revision of the N supply by N2 fixation to 10.2±6.9×10 11 mol N y-1.
    Materialart: Online-Ressource
    Seiten: graph. Darst
    ISSN: 1726-4189
    Sprache: Englisch
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Oxford, UK; Malden, USA : Blackwell Science Inc
    Wound repair and regeneration 13 (2005), S. 0 
    ISSN: 1524-475X
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: It has been known for several decades that early gestational human fetuses will regenerate cutaneous wounds resulting in a scarless repair. In postnatal humans, myofibroblasts are known to play a central role in wound healing and in the pathology of fibrosis. The role of the profibrotic growth factor TGF-β1 in human fetal fibroblasts remains unclear, with recent data now showing that TGF-β1 is present in fetal wounds but for shorter periods. We have therefore examined the effects of TGF-β1 on fibroblasts isolated from early human fetuses (〈14week EGA). We have identified that stimulation with 5 ng/ml TGF-β1 induces a significant proportion of human fetal fibroblasts to differentiate into myofibroblasts (approximately 40%), as identified by staining of α-smooth muscle actin (n = 5). Interestingly, this response was earlier (peaking at day 2–3) and more transitory (over by day 4–5) than that seen with postnatal dermal fibroblasts (peaking at day 6–8 and dropping at day 10). We examined the effects of blocking various intracellular pathways involved in TGF-β1 signalling. The early and transitory myofibroblast induction seen in fetal cells is blocked by an inhibitor of p-JNK (n = 4; p =〈 0.05). In contrast, the later and more prolonged induction of myofibroblasts seen in postnatal cells was not affected by inhibition of p-JNK. Despite the fact that fetal fibroblasts do indeed differentiate into myofibroblasts they were further shown to exhibit differential behavior to postnatal myofibroblasts with respect to TGF-β1 stimulation of collagen expression, producing significantly less soluble collagen (approximately 50%, n = 4) after 24 or 48 hours of treatment with TGF-β1 in serum-free media. These results appear to indicate a role for TGF-β1 during cutaneous wound healing in the early fetus and show that the response of fetal cells to this important profibrotic cytokine is rapid and more controlled, being short lived. It is possible that a prolonged response to this cytokine may lead to the overblown nature of postnatal wound healing, resulting in fibrosis.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 87 (1980), S. 0 
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Plasma prostaglandin F (PGF) was measured by a radioimmunoassay method in 24 subjects with tumours of the female genital tract. Levels in the tumour group ranged from 25 pg/ml to 134 pg/ml and were almost all greater than the values observed in a control group of 41 healthy women who had a mean (±SD) level of 21 (±3.4) pg/ml. There was a relationship between plasma PGF levels and the stage of the disease. Patients with resectable tumours showed a fall in PGF levels postoperatively and those with disseminated malignancy demonstrated increasing levels as the disease progressed. Plasma PGF may provide a clinical prognostic marker in the management of patients with malignant tumours.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 83 (1976), S. 0 
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The concentration of free fatty acids was measured in blood taken from the umbilical artery and vein of 29 infants during elective Caesarean section and compared with levels in maternal venous blood. The mean venous-arterial (v–a) difference was 0·07 mEq/1. There was a direct and significant correlation between the umbilical v–a difference and maternal venous concentrations.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 84 (1977), S. 0 
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Termination of pregnancy was performed under local anaesthesia as an outpatient procedure on 251 patients. The gestational ages ranged from 5 to 12 weeks. Either the portable Karman curette equipment or the syringe kits were used. The incidence of complications was low. Only 6 per cent of patients would have preferred general anaesthesia. The optimal gestational age at which to terminate pregnancies appeared to be between 6 and 10 weeks. Ninety-one per cent of patients used effective contraception after the termination.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: One hundred patients with an incomplete abortion, 14 patients with retained products of conception after a second trimester termination, 5 patients with missed abortion and 2 patients with secondary postpartum haemorrhages (making a total of 121 patients) had a uterine evacuation in a treatment room using the portable Karman curette equipment. No general anaesthesia was used but patients were given intravenous pethidine or papavaretum (Omnopon) and diazepam. Four patients found the procedure painful but only two of them would have preferred general anaesthesia. There were no immediate complications but three patients required re-evacuation of the uterus.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    s.l. : American Chemical Society
    Analytical chemistry 52 (1980), S. 1310-1312 
    ISSN: 1520-6882
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 81 (1974), S. 0 
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Pneumoperitoneum for laparoscopy was induced in a series of 105 patients by inserting the Verres needle through the uterine fundus. The results indicate that this technique is simple and safe.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 39 (1984), S. 0 
    ISSN: 1365-2044
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Ninety patients, premedicated with temazepam 20 mg, undergoing suction termination of pregnancy, were studied. Forty patients received alfentanil (500 μ g), and thirty halothane (1.5%) as supplements to either etomidate or methohexitone–nitrous oxide–oxygen anaesthesia. A further 20 patients received alfentanil 250 μg at induction of anaesthesia with methohexitone, followed by a further 250 μg immediately prior to the onset of surgery. Recovery was assessed by the time patients took to open eyes on command, to giving their correct date of birth, and to performing the deletion test. Satisfactory operating conditions were not obtained with the combination of etomidate and halothane. Faster recovery was seen in patients with either etomidate or methohexitone and receiving alfentanil (p 〈 0.01) Testing by the ‘p’ deletion test showed impaired psychomotor performance at 30 minutes after cessation of anaesthesia in all groups compared with the pre-operative scores. Side effects leading to unsatisfactory anaesthesia were more frequent in patients who had received etomidate (p 〈0.01).
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 38 (1983), S. 0 
    ISSN: 1365-2044
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Four out of 100 patients undergoing regional hip block (obturator nerve and nerve to obturator femoris) developed convulsions. These followed the injection of bupivacaine to block the nerve to the quadratus femoris muscle. The reasons for this are discussed. Not only has hip nerve regional blockade been shown to be ineffective in the relief of chronic pain of osteoarthritis but it must be concluded that the method described carries on unacceptably high morbidity.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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