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  • Articles  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    High doses of neomycin sulfate and the absorption of glucose and xylose from the rat small intestine (1966)
    Springer
    Digestive diseases and sciences 11 (1966), S. 923-929 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neomycin sulfate, at doses of 250 mg./kg. or 2 gm./kg., was instilled intragastrically, in male Fisher-strain rats daily for 21 days. Pair-fed controls received an equal amount of saline intragastrically for an equal period. After 3 weeks of treatment animals were tested by our modification of the Cori method to assess the absorption of xylose, glucose, and a mixture of xylose and glucose. Rats receiving neomycin at both doses demonstrated an enhanced absorption of glucose. A significant reduction in the absorption of xylose was noted in animals treated with 2 gm./kg. of neomycin. When glucose and xylose were administered together to rats receiving 2 gm./kg. of neomycin, a significant reduction in the absorption of xylose and an enhancement in the absorption of glucose was observed. Histologic examination revealed no constant alterations in the appearance of the small intestinal mucosa of the neomycin-treated rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02233080
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Diphenidol, A new antiemetic: A double-blind, placebo-controlled study (1966)
    Springer
    Digestive diseases and sciences 11 (1966), S. 648-651 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Placebo or diphenidol, a new nonphenothiazine antiemetic, was given to 30 patients with severe nausea and vomiting due to conditions including uremia, metastatic cancer, and hepatic decompensation. Diphenidol provided relief from nausea and vomiting that was significantly greater than the relief provided by placebo (P〈0.02 and P〈0.02). In the dosage required to control the symptoms, diphenidol did not cause any side effects that interfered with other medical treatment. The antiemetic activity of diphenidol appeared to be equivalent to that of the phenothiazines. Moreover, in the recommended antiemetic doses, diphenidol did not cause any of the side effects that can occur with the phenothiazines. Finally, in doses higher than those recommended for antiemetic activity, diphenidol appeared to be useful in controlling prolonged, intractable singultus. This impression should be confirmed by controlled studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02233513
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    Paper (German National Licenses)
    Fulltext
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