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  • 1
    Electronic Resource
    Electronic Resource
    DDT-induced tremor in rats: Effects of pharmacological agents (1985)
    Springer
    Psychopharmacology 86 (1985), S. 426-431 
    Details
    ISSN: 1432-2072
    Keywords: DDT ; Tremor ; Trihexyphenidyl ; 5,5-Diphenylhydantoin ; Pizotifen ; Mephenesin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats given a tremorigenic dose of DDT (75 mg/kg, PO) were treated with pharmacological agents either 30 min prior to DDT or 1–2 h prior to testing at the time of peak effect (12 h postdosing). The administration of mephenesin (a centrally acting muscle relaxant) or Dilantin (an anticonvulsant) prior to DDT significantly attenuated tremor. Pretreatment with pizotifen (a serotonergic receptor antagonist) had no significant effect on tremor. Administration of the same agents 1–2 h prior to measurement had minimal effects. Trihexyphenidyl (a muscarinic cholinergic receptor antagonist) exacerbated the tremor produced by DDT. These data suggest that cholinergic neurotransmitter systems may be involved in DDT-induced tremor. That DDT-induced tremor was significantly attenuated by mephenesin and Dilantin is in accord with the conclusion that DDT-induced tremor is a manifestation of repetitive discharge due to interference with ionic conductance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427903
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Pharmacological modification of tremor and enhanced acoustic startle by chlordecone and p,p′-DDT (1987)
    Springer
    Psychopharmacology 91 (1987), S. 320-325 
    Details
    ISSN: 1432-2072
    Keywords: Tremor ; Acoustic startle ; Chlordecone ; DDT ; Adrenergic system ; Calcium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pretreatment of rats with phenoxybenzamine (5 mg/kg; SC), an alpha adrenergic antagonist, decreased the peak tremor power and startle magnitude of rats subsequently given DDT (75 mg/kg; PO) or chlordecone (60 mg/kg; IP), without having a significant effect on control animals. Pretreatment with an intracerebroventricular injection of calcium (3.75 μM in 5 μl NaCl) decreased the peak tremor power due to subsequently administered DDT, while increasing the tremor response in rats later dosed with chlordecone. The effects of phenoxybenzamine are postulated to be due to a blockade of an excitatory influence of the adrenergic system. Calcium may decrease DDT-induced tremor by acting as a neuronal stabilizer. Potentiation of the tremorigenic effect of chlordecone by calcium may be due to increased levels of intracellular calcium, resulting in augmented release of neurotransmitters in chlordecone-exposed animals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00518184
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    Paper (German National Licenses)
    Fulltext
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