ISSN:
1432-2072
Keywords:
Tremor
;
Acoustic startle
;
Chlordecone
;
DDT
;
Adrenergic system
;
Calcium
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Pretreatment of rats with phenoxybenzamine (5 mg/kg; SC), an alpha adrenergic antagonist, decreased the peak tremor power and startle magnitude of rats subsequently given DDT (75 mg/kg; PO) or chlordecone (60 mg/kg; IP), without having a significant effect on control animals. Pretreatment with an intracerebroventricular injection of calcium (3.75 μM in 5 μl NaCl) decreased the peak tremor power due to subsequently administered DDT, while increasing the tremor response in rats later dosed with chlordecone. The effects of phenoxybenzamine are postulated to be due to a blockade of an excitatory influence of the adrenergic system. Calcium may decrease DDT-induced tremor by acting as a neuronal stabilizer. Potentiation of the tremorigenic effect of chlordecone by calcium may be due to increased levels of intracellular calcium, resulting in augmented release of neurotransmitters in chlordecone-exposed animals.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00518184
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