GLORIA

GEOMAR Library Ocean Research Information Access

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    An elementary lemma on sequences of integers and its applications to functional analysis (1972)
    Springer
    Mathematische Zeitschrift 126 (1972), S. 299-307 
    Details
    ISSN: 1432-1823
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01110335
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Hair cell regeneration in the bird cochlea following noise damage or ototoxic drug damage (1994)
    Springer
    Anatomy and embryology 189 (1994), S. 1-18 
    Details
    ISSN: 1432-0568
    Keywords: Hair cell ; Regeneration ; Avian ; Progenitor cells ; Basilar papilla
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Hair cells are sensory cells that transduce motion into neural signals. In the cochlea, they are used to detect sound waves in the environment and turn them into auditory signals that can be processed in the brain. Hair cells in the cochlea of birds and mammals were thought to be produced only during embryogenesis and, once made, they were expected to last throughout the lifetime of the animal. Thus, any loss of hair cells due to trauma or disease was thought to lead to permanent impairment of auditory function. Recently, however, studies from a number of laboratories have shown that hair cells in the avian cochlea can be regenerated after acoustic trauma or ototoxic drug damage. This regeneration is accompanied by a repair of the sensory organ and associated tissues and results in a recovery of auditory function. In this review, we examine and compare the structural events that lead to hair cell loss after noise damage and ototoxic drug damage as well as the processes involved in the recovery of the epithelium and the regeneration of the hair cells. Moreover, we examine functional recovery and how it relates to the structural recovery. Finally, we investigate the evidence for the hypothesis that supporting cells in the basilar papilla act as the progenitor cells for the regenerated hair cells and examine the cellular events required to stimulate the progenitor cells to leave the quiescent state, re-enter the cell cycle, and divide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00193125
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Continuous transepidermal drug collection: Basis for use in assessing drug intake and pharmacokinetics (1981)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 9 (1981), S. 41-58 
    Details
    ISSN: 1573-8744
    Keywords: transepidermal ; pharmacokinetics ; bioavailability ; drug surveillance ; compliance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Continuous transepidermal drug collection (CTDC) has been proposed for use in assessing ethanol intake and in monitoring compliance with therapeutic regimens. Exploration of a theoretical basis for use of CTDC in these circumstances and for its use in assessing other aspects of drug disposition kinetics was undertaken. Effects of single and multicompartmental drug disposition models, single dose and multiple dose regimens, with regular and irregular doses and dosing intervals, and zero-order, first-order, and Michaelis-Menten excretion patterns were explored. First-order transepidermal drug transfer was assumed with and without back transfer from the collection device. These analyses suggest that the utility of CTDC is severely restricted when back transfer from the collection device is substantial. With back transfer minimized, CTDC may be a useful tool for assessing amount of drug exposure, compliance with therapeutic regimens, and relative bioavailability, but offers little advantage over discrete sampling of other body fluids in the study of other aspects of drug disposition kinetics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01059342
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Decreased mucosal IgA levels in ileum of patients with chronic ulcerative colitis (1995)
    Springer
    Digestive diseases and sciences 40 (1995), S. 805-811 
    Details
    ISSN: 1573-2568
    Keywords: immunoglobulin A ; ulcerative colitis ; ileum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Patients with chronic ulcerative colitis (CUC) are known to have decreased spontaneous IgA secretion by colonic mononuclear cells. The aim of this study was to determine whether a similar alteration exists in the apparently healthy ileum of patients with CUC. The concentration of IgA was measured in the supernatant from homogenized mucosal ileal biopsies using a sandwich-type ELISA. The concentration of IgA was significantly (P=0.025) decreased in the ileum of patients with CUC (N=24) in comparison to normal ileum (N=10). The number of mucosal IgA-containing mononuclear cells (MNC) was also determined using an avidin-biotin-immunoperoxidase technique on paraffin-embedded ileal sections. Although reduced, the number of positive cells and their distribution was not significantly different in the ileum of patients with CUC (N=20) when compared to normal ileum (N=10). We suggest that decreased mucosal IgA levels are a panintestinal condition in CUC and that this is a primary alteration rather than a secondary response to the inflammatory process. Considering the role of IgA, we propose that decreased mucosal IgA levels in CUC may predispose to the disease by a reduction of the immune-mediated exclusion mechanism and/or by an impairment of the down-regulation of the inflammatory response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02064983
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Myoelectric activity and absorptive capacity of rat small intestinal isografts (1996)
    Springer
    Digestive diseases and sciences 41 (1996), S. 1082-1087 
    Details
    ISSN: 1573-2568
    Keywords: small intestine ; transplantation ; gastrointestinal motility ; intestinal absorption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of transplantation on small intestinal absorption, digestive capacity, myoelectric activity, and morphology was assessed in inbred Lewis rats. Electrodes were sutured to the duodenum and isografted jejunoileum or to the native jejunoileum in controls. The frequency of migrating myoelectric complexes (MMCs) in the duodenum was 3.3±0.3/hr in controls and 1.8±0.4/hr in transplants (P〈0.05). MMC frequency in the jejunoileum was 5.1±1.3/hr in controls and 3.2±0.9/hr in transplants (P〉0.05). MMCs appeared to migrate from the duodenum to the jejunoileum 80±3% of the time in controls and 59±7% of the time in transplant rats (P〈0.05). Absorption in the transplanted jejunoileum demonstrated a 35–40% decrease in glucose and electrolytes absorption. Villus height and number of nuclei per villus was reduced. Intestinal length (dry) was 103±6 cm for controls and 51±3 cm for transplant rats (P〈0.05). Brush border sucrase activity was unchanged. We conclude that small intestinal isografts display similar myoelectric activity as controls, but the decreased absorptive capacity and villus height may require longer segments of intestine to be transplanted in order to support normal nutrition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02088223
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Modeling the Transport of Contaminants Originating from the Dissolution of DNAPL Pools in Aquifers in the Presence of Dissolved Humic Substances (2000)
    Springer
    Transport in porous media 38 (2000), S. 93-115 
    Details
    ISSN: 1573-1634
    Keywords: contaminant transport ; transport of humic substances ; NAPL pool dissolution ; dissolved organic carbon ; aquifer remediation ; numerical modeling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Technology
    Notes: Abstract A two‐dimensional finite difference numerical model was developed to describe the transport of dissolved organics originating from nonaqueous phase liquid (NAPL) pool dissolution in saturated porous media in the presence of dissolved humic substances. A rectangular NAPL pool was considered in a homogeneous porous medium with unidirectional interstitial groundwater velocity. It was assumed that dissolved humic substances and aqueous phase contaminants may sorb onto the solid matrix under local equilibrium conditions. The contaminant in the aqueous phase may undergo first‐order decay. Also, the dissolved contaminant may sorb onto humic substances. The transport properties of dissolved humic substances are assumed to be unaffected by sorbing contaminants, because dissolved humic macromolecules are much larger than dissolved contaminants and sorption of nonpolar contaminants onto humic substances do not affect the overall surface charge of humic substances. The sorption characteristics of dissolved humic substances onto clean sand were determined from column experiments. An effective local mass transfer rate coefficient accounting for the presence of dissolved humic substances was developed. Model simulations indicate that dissolved humic substances substantially increase NAPL pool dissolution, and consequently reduce the required pump‐and‐treat aquifer remediation time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006674114600
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Normalised radionuclide measures of left ventricular diastolic function (1989)
    Springer
    European journal of nuclear medicine 15 (1989), S. 123-127 
    Details
    ISSN: 1619-7089
    Keywords: Radionuclide gated heart pool scan ; Diastole ; Peak filling rate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Abnormal left ventricular diastolic function is being increasingly recognised in patients with clinical heart failure and normal systolic function. A simple routine radionuclide measure of diastolic function would therefore be useful. To establish this, the relationship of peak diastolic filling rate (normalized for either end diastolic volume, stroke volume, or peak systolic emptying rate), and heart rate, age, and left ventricular ejection fraction was studied in 64 subjects with normal cardiovascular systems using routine gated heart pool studies. The peak filling rate, when normalized to end diastolic volume, correlated significantly with heart rate, age and left ventricular ejection fraction, whereas normalization to stroke volume correlated significantly to heart rate and age but not to left ventricular ejection fraction. Peak filling rate normalized for peak systolic emptying rate correlated with age only. Multiple regression equations were determined for each of the normalized peak filling rates in order to establish normal ranges for each parameter. When using peak filling rate normalized for end diastolic volume or stroke volume, appropriate allowance must be made for heart rate, age and ejection fraction. Peak filling rate normalized to peak ejection rate is a heart rate independent parameter which allows the performance of the patient's ventricle in diastole to be compared with its systolic function. It may be used in patients with normal systolic function to serially follow diastolic function or if age corrected, to screen for diastolic dysfunction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00254623
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...