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  • 1
    Electronic Resource
    Electronic Resource
    Restriction analysis of chromosomal sequences homologous to single-copy fragments cloned from small polydisperse circular DNA (spcDNA) (1989)
    Springer
    Human genetics 〈Berlin〉 82 (1989), S. 249-254 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Restriction fragments from the fraction of small polydisperse circular DNA (spcDNA) were cloned in pBR322. The spcDNA was prepared from cell cultures derived from an angiofibroma of a patient with tuberous sclerosis (TS). Such cultures have been shown previously to contain increased amounts of spcDNA. Four cloned spcDNA fragments containing single-copy sequences were chosen to characterize the homologous chromosomal DNA segments by restriction analysis. When used as hybridization probes, these four fragments generate well-defined nonvariable patterns in the chromosomal DNA from healthy donors. The restriction patterns obtained with one of the fragments (D-C4) can best be interpreted by assuming the presence of two copies of the homologous sequences in chromosomal DNA. A second sequence, A-B4, occurs at least 30–50 times in the haploid human genome. In both cases the duplicated regions span relatively large segments of DNA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00291164
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Analysis of human extrachromosomal DNA elements originating from different β-satellite subfamilies (1993)
    Springer
    Human genetics 〈Berlin〉 91 (1993), S. 489-495 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract By screening total human DNA with probes derived from the small polydisperse circular (spc) DNA fraction of cultured human cells, we identified three clones that carry long stretches of β-satellite DNA. Further experiments have shown that the three sequences belong to at least two different β-satellite subfamilies, which are characterized by different higher order subunits. Members of one of these subfamilies are located in the cytological satellites of all acrocentric chromosomes, whereas members of another are located on the short arms of the acrocentrics on both sides of the stalk regions and also in the centromeric regions of chromosomes 1 and 9. This is the first time that β-satellite sequences obtained from the spcDNA of human cells have been assigned to β-satellite subfamilies that are organized as long arrays of tandemly arranged higher order monomers. This indicates that β-satellite sequences can be excised from their chromosomal loci via intrastrand-recombination processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00217778
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The human vitronectin (complement S-protein) gene maps to the centromeric region of 17q (1992)
    Springer
    Human genetics 〈Berlin〉 88 (1992), S. 569-572 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Vitronectin (complement S-protein, serumspreading factor, epibolin) is a multifunctional glycoprotein that mediates cell-to-substrate adhesion, inhibits the cytolytic action of the terminal complement cascade in vitro and binds to several serine protease inhibitors of the serpin family, viz. antithrombin III, plasminogen activator inhibitor I (PAI-1) and II (PAI-2), heparin cofactor II and protease nexin. Using high resolution fluorescence in situ hybridization, we mapped the vitronectin gene to the centromeric region of the long arm of chromosome 17 corresponding to 17q11. The location was confirmed by co-hybridization with the centromerespecific alphoid probe p17H8 (D17Z1) and by chromosome banding with 4,6-diamidino-2-phenylindole-dihydrochloride (DAPI). None of the previously mapped genes that are evolutionary related to vitronectin are located on the same chromosome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00219346
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