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  • PANGAEA  (29)
  • Springer  (4)
Publikationsart
Schlagwörter
Erscheinungszeitraum
  • 1
    ISSN: 1432-2072
    Schlagwort(e): Key words Anxiolytic ; Anxiety ; Benzodiazepine ; GABAA ; 5-HT1A ; Neuroactive steroid
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  Rationale: Conflict procedures used to detect anxiolytic-like activity of drugs often rely on maintaining strict schedules of water or food availability. It is ethically and practically desirable to reduce such states of deprivation in animal testing. Objective: The purpose of the present experiment was to develop and pharmacologically characterize a conflict drinking procedure that did not require the use of water-deprived animals. Methods: Rats were tested during daily sessions with alternating unpunished drinking (no tone: lick=sucrose solution) and signaled punished drinking (tone: lick=sucrose+shock) components, and developed individual steady baselines over a brief training period (approximately 3–4 weeks). The drugs tested i.p. were the positive allosteric modulators of γ-amino butyric acidA (GABA)A receptors, diazepam (0.03–30 mg/kg), chlordiazepoxide (0.03–30 mg/kg), lorazepam (0.03–10 mg/kg), zolpidem (0.3–10 mg/kg), pentobarbital (1–30 mg/kg), pregnanolone (1–30 mg/kg), and bretazenil (0.03– 10 mg/kg); the 5-hydroxy tryptamine1A (HT)1A-mediated anxiolytics, buspirone (1–10 mg/kg) and ipsapirone (1–17 mg/kg); and the negative controls d-amphetamine (0.3–3 mg/kg), haloperidol (0.01–0.3 mg/kg), morphine (0.3–17 mg/kg), and imipramine (0.3–30 mg/kg). Results: The experimental procedure was sensitive to increases in punished drinking by the GABAA-positive modulators, consistent with their known or putative anxiolytic activity. Further, the 5-HT1A-mediated anxiolytics increased punished drinking, although to a lesser extent and over a more narrow dose range than did the GABAergic drugs. In contrast, d-amphetamine, haloperidol, morphine, and imipramine failed to increase punished drinking up to doses that decreased unpunished drinking. Conclusions: The present results indicate that water deprivation is not a necessary condition to engender drinking conflict behavior or to obtain pharmacological effects similar to those obtained with other classical conflict procedures.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    ISSN: 1432-2072
    Schlagwort(e): Key words Allopregnanolone ; Pregnanolone ; Neurosteroid ; Neuroactive steroid ; Motor behavior ; Ethanol interaction ; Benzodiazepine ; Triazolam ; Diazepam
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Endogenous pregnane steroids, such as allopregnanolone (3α-hydroxy-5α-pregnan-20-one; 3α, 5α-P) and pregnanolone (3α-hydroxy-5β-pregnan-20-one; 3α,5β-P), allosterically modulate GABAA receptor function and exhibit behavioral effects similar to benzodiazepines, though acting at a distinct recognition site. Inasmuch as some positive allosteric modulators of GABAA receptor function exhibit profound interactions with ethanol, the effects of 3α,5α-P and 3α,5β-P were compared to those of two benzodiazepines, triazolam and diazepam, on the motor function of mice and rats when administered either alone or in combination with ethanol. All four test compounds exhibited dose-related impairment of motor function in the horizontal wire task in mice and the rotorod task in rats. Ethanol caused a marked enhancement of triazolam- and diazepam-induced motor impairment. In contrast, ethanol enhanced to a lesser extent the motor impairment induced by both neurosteroids in mice and not at all in rats. All four compounds increased ethanol-induced behavioral sleep time in mice, although the benzodiazepines did so at a much smaller fraction of their ataxic doses as compared to the neurosteroids. As one of the undesired side-effects of therapeutic use of benzodiazepines is their interaction with ethanol, development of neuroactive steroids as drugs may offer therapeutic advantages.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    ISSN: 1432-2072
    Schlagwort(e): Key words Neurosteroid ; Cocaine ; Ganaxolone ; Co 2-1068 ; Haloperidol ; Locomotion ; Food intake
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  Rationale: Neuroactive steroids, including the potent anticonvulsants ganaxolone (3α-hydroxy-3β-methyl-5α-pregnan-20-one) and Co 2-1068 (3β-(4acetylphenyl)ethynyl-3α,21-dihydroxy-5β-20-one-21-hemisuccinate), have recently been shown to protect against cocaine-induced seizures. Objectives: The purpose of the present experiments was to determine whether ganaxolone and Co 2-1068 attenuate acute behavioral effects of cocaine unrelated to seizures. Methods: In the first experiment, the locomotor effects of Co 2-1068 (10–100 mg/ kg), pentobarbital (10–100 mg/kg) and haloperidol (0.03–0.3 mg/kg), alone or in combination with cocaine (5.6–30 mg/kg), were determined in mice. In the second experiment, the effects on sucrose intake of ganaxolone (4–16 mg/kg), Co 2-1068 (8–64 mg/kg), pentobarbital (4–32 mg/kg), and haloperidol (0.04–0.4 mg/kg), alone or in combination with cocaine (4–16 mg/kg), were determined in rats. Results: Cocaine caused a dose-related increase in locomotor activity in mice, whereas Co 2-1068, pentobarbital and haloperidol caused dose-related decreases. The dopamine antagonist haloperidol, at a dose that had no effect on activity by itself, but not Co 2-1068 or pentobarbital, attenuated the cocaine-induced increase in locomotor activity. Cocaine, ganaxolone, Co 2-1068, and haloperidol produced dose-related decreases in sucrose intake in rats; the effects of pentobarbital on sucrose intake were variable. As with locomotor effects, haloperidol attenuated the cocaine-induced decrease in sucrose intake. In addition, cocaine-induced decreases in sucrose intake were attenuated by ganaxolone and Co 2-1068. Pentobarbital had no statistically significant effect on the cocaine dose-response function. Conclusions: These results suggest that the interaction of neuroactive steroids with cocaine extends to pharmacologic actions beyond anticonvulsant efficacy, but that the blockade of behavioral effects of cocaine by neuroactive steroids does not apply to all acute behaviors.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
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    Unbekannt
    PANGAEA
    In:  Supplement to: Pagani, Mark; Pedentchouk, Nikolai; Huber, Matthew; Sluijs, Appy; Schouten, Stefan; Brinkhuis, Henk; Sinninghe Damsté, Jaap S; Dickens, Gerald Roy; Expedition 302 Scientists (2006): Arctic hydrology during global warming at the Palaeocene/Eocene thermal maximum. Nature, 442(10), 671-675, https://doi.org/10.1038/nature05043
    Publikationsdatum: 2023-06-27
    Beschreibung: The Palaeocene/Eocene thermal maximum represents a period of rapid, extreme global warming approx ~55 million years ago, superimposed on an already warm world (Zachos et al., 2003, doi:10.1126/science.1090110; Bowen et al., 2004, doi:10.1038/nature03115; Thomas et al., 2002, doi:10.1130/0091-7613(2002)030〈1067:WTFFTF〉2.0.CO;2). This warming is associated with a severe shoaling of the ocean calcite compensation depth **4 and a 〉2.5 per mil negative carbon isotope excursion in marine and soil carbonates (Zachos et al., 2003, doi:10.1126/science.1090110; Bowen et al., 2004, doi:10.1038/nature03115; Thomas et al., 2002, doi:10.1130/0091-7613(2002)030〈1067:WTFFTF〉2.0.CO;2; Zachos et al., doi:10.1126/science.1109004). Together these observations indicate a massive release of 13C-depleted carbon (Zachos et al., doi:10.1126/science.1109004) and greenhouse-gas-induced warming. Recently, sediments were recovered from the central Arctic Ocean (Backman et al., 2006, doi:10.2204/iodp.proc.302.2006), providing the first opportunity to evaluate the environmental response at the North Pole at this time. Here we present stable hydrogen and carbon isotope measurements of terrestrial-plant- and aquatic-derived n-alkanes that record changes in hydrology, including surface water salinity and precipitation, and the global carbon cycle. Hydrogen isotope records are interpreted as documenting decreased rainout during moisture transport from lower latitudes and increased moisture delivery to the Arctic at the onset of the Palaeocene/Eocene thermal maximum, consistent with predictions of poleward storm track migrations during global warming (Backman et al., 2006, doi:10.2204/iodp.proc.302.2006). The terrestrial-plant carbon isotope excursion (about ~4.5 to ~6 per mil) is substantially larger than those of marine carbonates. Previously, this offset was explained by the physiological response of plants to increases in surface humidity (Bowen et al., 2004, doi:10.1038/nature03115). But this mechanism is not an effective explanation in this wet Arctic setting, leading us to hypothesize that the true magnitude of the excursion - and associated carbon input - was greater than originally surmised. Greater carbon release and strong hydrological cycle feedbacks may help explain the maintenance of this unprecedented warmth.of this unprecedented warmth.
    Schlagwort(e): 302-M0004A; ACEX-M4A; Arctic Coring Expedition, ACEX; Arctic Ocean; CCGS Captain Molly Kool (Vidar Viking); DEPTH, sediment/rock; Exp302; Integrated Ocean Drilling Program / International Ocean Discovery Program; IODP; Mass spectrometer, Finnigan, MAT 253; n-Alkane C17, δ13C; n-Alkane C17, δ13C, standard deviation; n-Alkane C17, δD; n-Alkane C17, δD, standard deviation; n-Alkane C27, δ13C; n-Alkane C27, δ13C, standard deviation; n-Alkane C27, δD; n-Alkane C27, δD, standard deviation; n-Alkane C29, δ13C; n-Alkane C29, δ13C, standard deviation; n-Alkane C29, δD; n-Alkane C29, δD, standard deviation; Sample code/label
    Materialart: Dataset
    Format: text/tab-separated-values, 417 data points
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Publikationsdatum: 2023-08-12
    Schlagwort(e): 94-608; Acyclic glycerol dialkyl glycerol tetraether, fractional abundance; AGE; Comment; Crenarchaeol, fractional abundance; Crenarchaeol regio-isomer; Deep Sea Drilling Project; DEPTH, sediment/rock; Dicyclic glycerol dialkyl glycerol tetraether, fractional abundance; DRILL; Drilling/drill rig; DSDP; DSDP/ODP/IODP sample designation; Glomar Challenger; Glycerol dialkyl glycerol tetraethers, fractional abundance Ia; Glycerol dialkyl glycerol tetraethers, fractional abundance Ib; Glycerol dialkyl glycerol tetraethers, fractional abundance Ic; Glycerol dialkyl glycerol tetraethers, fractional abundance IIa; Glycerol dialkyl glycerol tetraethers, fractional abundance IIb; Glycerol dialkyl glycerol tetraethers, fractional abundance IIc; Glycerol dialkyl glycerol tetraethers, fractional abundance IIIa; Glycerol dialkyl glycerol tetraethers, fractional abundance IIIb; Glycerol dialkyl glycerol tetraethers, fractional abundance IIIc; Isoprenoid glycerol dialkyl glycerol tetraether; Leg94; Monocyclic glycerol dialkyl glycerol tetraether, fractional abundance; North Atlantic/FLANK; Sample code/label; Tricyclic glycerol dialkyl glycerol tetraether, fractional abundance
    Materialart: Dataset
    Format: text/tab-separated-values, 2970 data points
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    Publikationsdatum: 2023-08-12
    Schlagwort(e): -; 94-608; AGE; Alkenone C37:2, δ13C; Carbon dioxide; Carbon dioxide, aquatic, fraction; Deep Sea Drilling Project; DEPTH, sediment/rock; DRILL; Drilling/drill rig; DSDP; Globigerinoides spp., δ13C; Glomar Challenger; Haptophytes, biomass, δ13C; Leg94; North Atlantic/FLANK; Sample code/label; Sea surface temperature, annual mean; SST, BAYSPAR (BAYesian SPAtially-varying Regression); δ13C, carbon dioxide, aquatic; δ13C, carbon dioxide, gaseous; ε
    Materialart: Dataset
    Format: text/tab-separated-values, 2584 data points
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    Publikationsdatum: 2023-08-12
    Schlagwort(e): 94-608; Acyclic glycerol dialkyl glycerol tetraether; AGE; Alkenone, unsaturation index UK'37; Branched and isoprenoid tetraether index; Branched glycerol dialkyl glycerol tetraether; Calculated, TEX86; Comment; Crenarchaeol; Deep Sea Drilling Project; DEPTH, sediment/rock; Difference; DRILL; Drilling/drill rig; DSDP; DSDP/ODP/IODP sample designation; Glomar Challenger; GSA Geological Time Scale v.4.0 2012; Isoprenoid glycerol dialkyl glycerol tetraether; Leg94; Methane index; North Atlantic/FLANK; Ratio; Ring index; Ring index of tetraether index of 86 carbon atoms; Sample code/label; Sample mass; Sea surface temperature, annual mean; SST, BAYSPAR (BAYesian SPAtially-varying Regression); SST, from UK'37; Tetraether index of 86 carbon atoms
    Materialart: Dataset
    Format: text/tab-separated-values, 3211 data points
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
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    Unbekannt
    PANGAEA
    In:  Supplement to: Super, James R; Thomas, Ellen; Pagani, Mark; Huber, Matthew; O'Brien, Charlotte; Hull, Pincelli M (2018): North Atlantic temperature and pCO2 coupling in the early-middle Miocene. Geology, 46(6), 519-522, https://doi.org/10.1130/G40228.1
    Publikationsdatum: 2023-08-12
    Beschreibung: Climate proxies indicate coupling between changes in atmospheric pCO2, global temperatures and ice volume over much of the Cenozoic. Evidence has been presented for decoupling of these factors in the Miocene, though the cause of the apparent decoupling was uncertain. Here, we revisit Deep Sea Drilling Program (DSDP) Site 608 (24-9 Ma) in the North Atlantic, to provide improved constraints on sea surface temperatures (SSTs) using the TEX86 and Uk'37 proxies, and use these to recalculate atmospheric pCO2. From the Oligocene/Miocene boundary to the middle Miocene Climatic Optimum (MCO, ~23.03 to ~14.5 Ma), SSTs at Site 608 were upwards of 30°C, nearly 15 °C warmer than modern. During the Middle Miocene Climatic Transition (MMCT), starting at ~14.5 Ma, SSTs cooled by ~ 6 °C These lower SSTs persisted until the end of our record (9 Ma). Our organic proxy derived SST estimates are considerably higher than those previously calculated from planktonic foraminiferal oxygen isotope data, leading to reassessed pCO2 estimates from alkenones ~65 to ~175 ppm higher than previously calculated, with other assumptions held constant. A pCO2 decrease from an average of ~430 ppm in MCO to ~305 ppm after the MMCT, in step with the ~6 °C SST cooling, demonstrates coupling of climate and the carbon cycle, as well as a highly sensitive climate system.
    Schlagwort(e): 94-608; Deep Sea Drilling Project; DRILL; Drilling/drill rig; DSDP; Glomar Challenger; Leg94; North Atlantic/FLANK
    Materialart: Dataset
    Format: application/zip, 3 datasets
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
    facet.materialart.
    Unbekannt
    PANGAEA
    In:  Supplement to: Sluijs, Appy; Schouten, Stefan; Pagani, Mark; Woltering, Martijn; Brinkhuis, Henk; Sinninghe Damsté, Jaap S; Dickens, Gerald Roy; Huber, Matthew; Reichart, Gert-Jan; Stein, Ruediger; Matthiessen, Jens; Lourens, Lucas Joost; Pedentchouk, Nikolai; Backman, Jan; Moran, Kathryn; Expedition 302 Scientists (2006): Subtropical Arctic Ocean temperatures during the Palaeocene/Eocene thermal maximum. Nature, 441, 610-613, https://doi.org/10.1038/nature04668
    Publikationsdatum: 2023-07-10
    Beschreibung: The Palaeocene/Eocene thermal maximum, 55 million years ago, was a brief period of widespread, extreme climatic warming (Zachos et al., 2003; Kennett and Stott, 1991, doi:10.1038/353225a0; Tripati and Elderfield, 2005, doi:10.1126/science.1109202), that was associated with massive atmospheric greenhouse gas input (Dickens et al., 1995, doi:10.1029/95PA02087). Although aspects of the resulting environmental changes are well documented at low latitudes, no data were available to quantify simultaneous changes in the Arctic region. Here we identify the Palaeocene/Eocene thermal maximum in a marine sedimentary sequence obtained during the Arctic Coring Expedition (Backman et al., 2006, doi:10.2204/iodp.proc.302.2006). We show that sea surface temperatures near the North Pole increased from 18 °C to over 23 °C during this event. Such warm values imply the absence of ice and thus exclude the influence of ice-albedo feedbacks on this Arctic warming. At the same time, sea level rose while anoxic and euxinic conditions developed in the ocean's bottom waters and photic zone, respectively. Increasing temperature and sea level match expectations based on palaeoclimate model simulations (Shellito et al., 2003, doi:10.1016/S0031-0182(02)00718-6), but the absolute polar temperatures that we derive before, during and after the event are more than 10 °C warmer than those model-predicted. This suggests that higher-than-modern greenhouse gas concentrations must have operated in conjunction with other feedback mechanisms -perhaps polar stratospheric clouds (Sloan and Pollard, 1998, doi:10.1029/98GL02492) or hurricane-induced ocean mixing (Emanuel et al., 2004, doi:10.1175/1520-0469(2004)061〈0843:ECOTCI〉2.0.CO;2)- to amplify early Palaeogene polar temperatures.
    Schlagwort(e): 302-M0004A; ACEX-M4A; Angiosperms; Apectodinium spp.; Arctic Coring Expedition, ACEX; Arctic Ocean; Areoligera complex; Caligodinium aceras; CCGS Captain Molly Kool (Vidar Viking); Cerodinium complex; Cordosphaeridium complex; DEPTH, sediment/rock; Dinoflagellate cyst; Dinoflagellate cyst, low salinity tolerant; Dinoflagellate cyst indeterminata; DSDP/ODP/IODP sample designation; Exp302; Foraminifera, linings per unit mass; Integrated Ocean Drilling Program / International Ocean Discovery Program; IODP; Membranosphaera complex; Palynomorpha, marine; Palynomorpha, terrestrial; Pollen, angiosperms; Pollen, gymnosperms; Polysphaeridium complex; Sample code/label; Senegalinium spp.; Spiniferites complex; Spores
    Materialart: Dataset
    Format: text/tab-separated-values, 1185 data points
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
    Publikationsdatum: 2024-01-09
    Beschreibung: Falling atmospheric CO2 levels led to cooling through the Eocene and the expansion of Antarctic ice sheets close to their modern size near the beginning of the Oligocene, a period of poorly documented climate. Here we present the first record of climate evolution across the entire Oligocene (33.9-23.0 Ma) based on new TEX86 Sea Surface Temperature (SST) estimates from southwestern Atlantic Deep Sea Drilling Project Site 516 (paleolatitude ~ 36°S) and western equatorial Atlantic Ocean Drilling Project Site 929 (paleolatitude ~ 0°), combined with a compilation of existing SST records and climate modeling. In this relatively low CO2 Oligocene world (~300-700 ppm), warm climates similar to those of the late Eocene continued with only brief interruptions, while the Antarctic ice sheet waxed and waned. SSTs are spatially heterogenous, but generally support late Oligocene warming coincident with declining atmospheric CO2. This Oligocene warmth, especially at high latitudes, belies a simple relationship between climate and atmospheric CO2 and/or ocean gateways, and is only partially explained by current climate models. Though the dominant climate drivers of this enigmatic Oligocene world remain unclear, our results help fill a gap in understanding past Cenozoic climates and the way long-term climate sensitivity responded to varying background climate states.
    Schlagwort(e): Deep Sea Drilling Project; DSDP; Ocean Drilling Program; ODP; Oligocene; TEX86
    Materialart: Dataset
    Format: application/zip, 2 datasets
    Standort Signatur Einschränkungen Verfügbarkeit
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