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  • 1
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] It has been suggested, on the basis of modern hydrology and fully coupled palaeoclimate simulations, that the warm greenhouse conditions that characterized the early Palaeogene period (55–45 Myr ago) probably induced an intensified hydrological cycle with precipitation exceeding ...
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  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 447 (2007), S. 577-580 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Ocean mixing affects global climate and the marine biosphere because it is linked to the ocean’s ability to store and transport heat and nutrients. Observations have constrained the magnitude of upper ocean mixing associated with certain processes, but mixing rates measured directly are ...
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  • 3
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Nature 442, 671–675 (2006) We omitted the names of the following authors of this Letter: Jens Matthiessen, Kathryn Moran and Ruediger ...
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  • 4
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The Palaeocene/Eocene thermal maximum represents a period of rapid, extreme global warming ∼55 million years ago, superimposed on an already warm world. This warming is associated with a severe shoaling of the ocean calcite compensation depth and a 〉2.5 per mil negative carbon ...
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  • 5
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The Palaeocene/Eocene thermal maximum, ∼55 million years ago, was a brief period of widespread, extreme climatic warming, that was associated with massive atmospheric greenhouse gas input. Although aspects of the resulting environmental changes are well documented at low latitudes, ...
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  • 6
    ISSN: 1432-2072
    Keywords: Key words Anxiolytic ; Anxiety ; Benzodiazepine ; GABAA ; 5-HT1A ; Neuroactive steroid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Rationale: Conflict procedures used to detect anxiolytic-like activity of drugs often rely on maintaining strict schedules of water or food availability. It is ethically and practically desirable to reduce such states of deprivation in animal testing. Objective: The purpose of the present experiment was to develop and pharmacologically characterize a conflict drinking procedure that did not require the use of water-deprived animals. Methods: Rats were tested during daily sessions with alternating unpunished drinking (no tone: lick=sucrose solution) and signaled punished drinking (tone: lick=sucrose+shock) components, and developed individual steady baselines over a brief training period (approximately 3–4 weeks). The drugs tested i.p. were the positive allosteric modulators of γ-amino butyric acidA (GABA)A receptors, diazepam (0.03–30 mg/kg), chlordiazepoxide (0.03–30 mg/kg), lorazepam (0.03–10 mg/kg), zolpidem (0.3–10 mg/kg), pentobarbital (1–30 mg/kg), pregnanolone (1–30 mg/kg), and bretazenil (0.03– 10 mg/kg); the 5-hydroxy tryptamine1A (HT)1A-mediated anxiolytics, buspirone (1–10 mg/kg) and ipsapirone (1–17 mg/kg); and the negative controls d-amphetamine (0.3–3 mg/kg), haloperidol (0.01–0.3 mg/kg), morphine (0.3–17 mg/kg), and imipramine (0.3–30 mg/kg). Results: The experimental procedure was sensitive to increases in punished drinking by the GABAA-positive modulators, consistent with their known or putative anxiolytic activity. Further, the 5-HT1A-mediated anxiolytics increased punished drinking, although to a lesser extent and over a more narrow dose range than did the GABAergic drugs. In contrast, d-amphetamine, haloperidol, morphine, and imipramine failed to increase punished drinking up to doses that decreased unpunished drinking. Conclusions: The present results indicate that water deprivation is not a necessary condition to engender drinking conflict behavior or to obtain pharmacological effects similar to those obtained with other classical conflict procedures.
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  • 7
    ISSN: 1432-2072
    Keywords: Key words Allopregnanolone ; Pregnanolone ; Neurosteroid ; Neuroactive steroid ; Motor behavior ; Ethanol interaction ; Benzodiazepine ; Triazolam ; Diazepam
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Endogenous pregnane steroids, such as allopregnanolone (3α-hydroxy-5α-pregnan-20-one; 3α, 5α-P) and pregnanolone (3α-hydroxy-5β-pregnan-20-one; 3α,5β-P), allosterically modulate GABAA receptor function and exhibit behavioral effects similar to benzodiazepines, though acting at a distinct recognition site. Inasmuch as some positive allosteric modulators of GABAA receptor function exhibit profound interactions with ethanol, the effects of 3α,5α-P and 3α,5β-P were compared to those of two benzodiazepines, triazolam and diazepam, on the motor function of mice and rats when administered either alone or in combination with ethanol. All four test compounds exhibited dose-related impairment of motor function in the horizontal wire task in mice and the rotorod task in rats. Ethanol caused a marked enhancement of triazolam- and diazepam-induced motor impairment. In contrast, ethanol enhanced to a lesser extent the motor impairment induced by both neurosteroids in mice and not at all in rats. All four compounds increased ethanol-induced behavioral sleep time in mice, although the benzodiazepines did so at a much smaller fraction of their ataxic doses as compared to the neurosteroids. As one of the undesired side-effects of therapeutic use of benzodiazepines is their interaction with ethanol, development of neuroactive steroids as drugs may offer therapeutic advantages.
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  • 8
    ISSN: 1432-2072
    Keywords: Key words Neurosteroid ; Cocaine ; Ganaxolone ; Co 2-1068 ; Haloperidol ; Locomotion ; Food intake
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Rationale: Neuroactive steroids, including the potent anticonvulsants ganaxolone (3α-hydroxy-3β-methyl-5α-pregnan-20-one) and Co 2-1068 (3β-(4acetylphenyl)ethynyl-3α,21-dihydroxy-5β-20-one-21-hemisuccinate), have recently been shown to protect against cocaine-induced seizures. Objectives: The purpose of the present experiments was to determine whether ganaxolone and Co 2-1068 attenuate acute behavioral effects of cocaine unrelated to seizures. Methods: In the first experiment, the locomotor effects of Co 2-1068 (10–100 mg/ kg), pentobarbital (10–100 mg/kg) and haloperidol (0.03–0.3 mg/kg), alone or in combination with cocaine (5.6–30 mg/kg), were determined in mice. In the second experiment, the effects on sucrose intake of ganaxolone (4–16 mg/kg), Co 2-1068 (8–64 mg/kg), pentobarbital (4–32 mg/kg), and haloperidol (0.04–0.4 mg/kg), alone or in combination with cocaine (4–16 mg/kg), were determined in rats. Results: Cocaine caused a dose-related increase in locomotor activity in mice, whereas Co 2-1068, pentobarbital and haloperidol caused dose-related decreases. The dopamine antagonist haloperidol, at a dose that had no effect on activity by itself, but not Co 2-1068 or pentobarbital, attenuated the cocaine-induced increase in locomotor activity. Cocaine, ganaxolone, Co 2-1068, and haloperidol produced dose-related decreases in sucrose intake in rats; the effects of pentobarbital on sucrose intake were variable. As with locomotor effects, haloperidol attenuated the cocaine-induced decrease in sucrose intake. In addition, cocaine-induced decreases in sucrose intake were attenuated by ganaxolone and Co 2-1068. Pentobarbital had no statistically significant effect on the cocaine dose-response function. Conclusions: These results suggest that the interaction of neuroactive steroids with cocaine extends to pharmacologic actions beyond anticonvulsant efficacy, but that the blockade of behavioral effects of cocaine by neuroactive steroids does not apply to all acute behaviors.
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  • 9
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    In:  Supplement to: Pagani, Mark; Pedentchouk, Nikolai; Huber, Matthew; Sluijs, Appy; Schouten, Stefan; Brinkhuis, Henk; Sinninghe Damsté, Jaap S; Dickens, Gerald Roy; Expedition 302 Scientists (2006): Arctic hydrology during global warming at the Palaeocene/Eocene thermal maximum. Nature, 442(10), 671-675, https://doi.org/10.1038/nature05043
    Publication Date: 2023-06-27
    Description: The Palaeocene/Eocene thermal maximum represents a period of rapid, extreme global warming approx ~55 million years ago, superimposed on an already warm world (Zachos et al., 2003, doi:10.1126/science.1090110; Bowen et al., 2004, doi:10.1038/nature03115; Thomas et al., 2002, doi:10.1130/0091-7613(2002)030〈1067:WTFFTF〉2.0.CO;2). This warming is associated with a severe shoaling of the ocean calcite compensation depth **4 and a 〉2.5 per mil negative carbon isotope excursion in marine and soil carbonates (Zachos et al., 2003, doi:10.1126/science.1090110; Bowen et al., 2004, doi:10.1038/nature03115; Thomas et al., 2002, doi:10.1130/0091-7613(2002)030〈1067:WTFFTF〉2.0.CO;2; Zachos et al., doi:10.1126/science.1109004). Together these observations indicate a massive release of 13C-depleted carbon (Zachos et al., doi:10.1126/science.1109004) and greenhouse-gas-induced warming. Recently, sediments were recovered from the central Arctic Ocean (Backman et al., 2006, doi:10.2204/iodp.proc.302.2006), providing the first opportunity to evaluate the environmental response at the North Pole at this time. Here we present stable hydrogen and carbon isotope measurements of terrestrial-plant- and aquatic-derived n-alkanes that record changes in hydrology, including surface water salinity and precipitation, and the global carbon cycle. Hydrogen isotope records are interpreted as documenting decreased rainout during moisture transport from lower latitudes and increased moisture delivery to the Arctic at the onset of the Palaeocene/Eocene thermal maximum, consistent with predictions of poleward storm track migrations during global warming (Backman et al., 2006, doi:10.2204/iodp.proc.302.2006). The terrestrial-plant carbon isotope excursion (about ~4.5 to ~6 per mil) is substantially larger than those of marine carbonates. Previously, this offset was explained by the physiological response of plants to increases in surface humidity (Bowen et al., 2004, doi:10.1038/nature03115). But this mechanism is not an effective explanation in this wet Arctic setting, leading us to hypothesize that the true magnitude of the excursion - and associated carbon input - was greater than originally surmised. Greater carbon release and strong hydrological cycle feedbacks may help explain the maintenance of this unprecedented warmth.of this unprecedented warmth.
    Keywords: 302-M0004A; ACEX-M4A; Arctic Coring Expedition, ACEX; Arctic Ocean; CCGS Captain Molly Kool (Vidar Viking); DEPTH, sediment/rock; Exp302; Integrated Ocean Drilling Program / International Ocean Discovery Program; IODP; Mass spectrometer, Finnigan, MAT 253; n-Alkane C17, δ13C; n-Alkane C17, δ13C, standard deviation; n-Alkane C17, δD; n-Alkane C17, δD, standard deviation; n-Alkane C27, δ13C; n-Alkane C27, δ13C, standard deviation; n-Alkane C27, δD; n-Alkane C27, δD, standard deviation; n-Alkane C29, δ13C; n-Alkane C29, δ13C, standard deviation; n-Alkane C29, δD; n-Alkane C29, δD, standard deviation; Sample code/label
    Type: Dataset
    Format: text/tab-separated-values, 417 data points
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  • 10
    Publication Date: 2023-08-12
    Keywords: 94-608; Acyclic glycerol dialkyl glycerol tetraether, fractional abundance; AGE; Comment; Crenarchaeol, fractional abundance; Crenarchaeol regio-isomer; Deep Sea Drilling Project; DEPTH, sediment/rock; Dicyclic glycerol dialkyl glycerol tetraether, fractional abundance; DRILL; Drilling/drill rig; DSDP; DSDP/ODP/IODP sample designation; Glomar Challenger; Glycerol dialkyl glycerol tetraethers, fractional abundance Ia; Glycerol dialkyl glycerol tetraethers, fractional abundance Ib; Glycerol dialkyl glycerol tetraethers, fractional abundance Ic; Glycerol dialkyl glycerol tetraethers, fractional abundance IIa; Glycerol dialkyl glycerol tetraethers, fractional abundance IIb; Glycerol dialkyl glycerol tetraethers, fractional abundance IIc; Glycerol dialkyl glycerol tetraethers, fractional abundance IIIa; Glycerol dialkyl glycerol tetraethers, fractional abundance IIIb; Glycerol dialkyl glycerol tetraethers, fractional abundance IIIc; Isoprenoid glycerol dialkyl glycerol tetraether; Leg94; Monocyclic glycerol dialkyl glycerol tetraether, fractional abundance; North Atlantic/FLANK; Sample code/label; Tricyclic glycerol dialkyl glycerol tetraether, fractional abundance
    Type: Dataset
    Format: text/tab-separated-values, 2970 data points
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