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  • Springer  (14)
  • 2005-2009
  • 2000-2004  (14)
Publikationsart
Schlagwörter
Verlag/Herausgeber
Erscheinungszeitraum
Jahr
  • 1
    Digitale Medien
    Digitale Medien
    Trypsin inhibitor activity of basidiomycetous mushrooms (2000)
    Springer
    European food research and technology 211 (2000), S. 346-348 
    Details
    ISSN: 1438-2385
    Schlagwort(e): Key wordsCraterellus ; Gomphidius ; Higher fungi ; Hydnum ; Hygrophorus, Laccaria ; Trypsin inhibitors
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Laccaria and Hygrophorus species, Craterellus cornucopioides, Gomphidius glutinosus, Macrolepiota rhacodes and Hydnum repandum. The inhibiting activities found were higher than those of cereals but lower than those of some fabaceous plants.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002170000180
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Pre-eclampsia associated alterations of the elastic fibre system in umbilical cord vessels (2000)
    Springer
    Anatomy and embryology 201 (2000), S. 291-303 
    Details
    ISSN: 1432-0568
    Schlagwort(e): Key words Blood vessel walls ; Intima thickening ; Lamina elastica interna splitting ; Morphology ; Elastin quantification
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  Although pre-eclampsia (PE) is often associated with fetal hypoxia, hypertension and/or disturbed function of the fetal circulation, the effect of these altered hemodynamic parameters on the structure and composition of umbilical vessels has not been systematically investigated before. Therefore, this study focuses on PE-associated changes of the elastic fibre system in umbilical cord vessels investigated by light and electron microscopy, immunocytochemistry and biochemistry. In umbilical cord veins, no changes in thickness of the vessel wall or of any sublayer were observed. However, the internal elastic lamina of the veins was split in 80% of the PE-group in contrast to 20% in uncomplicated pregnancies. This effect was significant (α 〈0.01) from 36 weeks of gestation onwards. In umbilical cord arteries, the entire arterial vessel wall was found to be 15% thicker in PE than in uncomplicated pregnancies. The enlargement was caused by an increase of both the tunica intima and tunica media. The thickening of the tunica intima was attributed to a migration of smooth muscle cells towards the endothelium, accompanied by a splitting of the internal elastic lamina. Compared to uncomplicated pregnancies, smooth muscle cells of arteries and veins in PE showed a metabolic activation demonstrated by highly dilated endoplasmic reticulum. A semiquantitative score method as well as a quantitative dot blot assay indicated a PE-associated reduction of elastin expression in the arterial vessel walls. In summary, PE obviously induces a decrease of the elastin content accompanied by a thickening of the vessel wall in umbilical cord arteries. This remodeling of the elastic fibre system, together with an increased migration of smooth muscle cells, might represent part of the functional adaptation system of the umbilical cord arteries on the altered hemodynamic conditions in PE.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004290050318
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Flexible tantalum stents for the treatment of renovascular hypertension: a 10-year experience (2000)
    Springer
    European radiology 10 (2000), S. 1144-1151 
    Details
    ISSN: 1432-1084
    Schlagwort(e): Key words: Renal arteries – Stenosis or obstruction – Renal arteries – Transluminal angioplasty – Stents and prostheses – Renal hypertension
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract. The aim of this study was to determine long-term success of flexible tantalum stents for the treatment of ostial and truncal renal artery stenosis. Since 1989, flexible tantalum stents (type Strecker) were implanted in 34 patients (36 arteries, 25 ostial lesions, 11 truncal lesions) with uncontrollable renovascular hypertension, 9 of them in association with renal insufficiency. Stents were placed unilaterally in 32 patients, and bilaterally in 2 patients for the treatment of renal artery stenosis. Thirty-five of 36 lesions were atherosclerotic, including 5 recurrencies after previous percutaneous transluminal renal angioplasty (PTRA). One patient had Takayasu arteritis. Stents were implanted after unsuccessful PTRA of 11 truncal and 23 ostial lesions, and as a primary procedure in 2 ostial lesions. Follow-up examinations included blood pressure measurement, determination of serum creatinine level, color duplex sonography, or angiography. The technical success rate was 92 %. Technical failure included incorrect stent placement (1 of 36 lesions, 2.8 %), and stent dislocation (2 of 36 lesions, 5.6 %), and two stents were retrieved percutaneously. In one case of Takayasu arteritis, residual stenosis of 40 % was observed. After technically successful stent placement, 77 % of patients became normotensive with or without medication. In the remaining patients there was partial improvement with blood pressure between 140 and 180 mmHg. Renal function improved in 76 % of patients (completely in 3 of 8, 38 %; and partially in 3 of 8, 38 %). Primary patency rate including all stented lesions and initial technical failures was 82.4 % ± 6.8 (1 year) and 82.4 % ± 9.2 (3 years). After technically successful stent placement, patency rates were 89.9 ± 5.6 % (1 year), and 89.9 ± 7.6 % (3 years). For ostial lesions, primary patency rate was 87.9 ± 6.7 % (1 year) and 87.9 ± 9.2 % (3 years). Placement of flexible tantalum stents in renal arteries is technically demanding, especially in ostial lesions. Once placed successfully, stent patency rate is excellent.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s003300000377
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  • 4
    Digitale Medien
    Digitale Medien
    The effect of C1-esterase inhibitor in definite and suspected streptococcal toxic shock syndrome. Report of seven patients (2000)
    Springer
    Intensive care medicine 26 (2000), S. 1566-1570 
    Details
    ISSN: 1432-1238
    Schlagwort(e): Streptococcal toxic shock syndrome Capillary leak syndrome Necrotizing fasciitis C1-esterase inhibitor
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract. Objective: To evaluate the effect of adjunctive C1-esterase inhibitor substitution therapy on clinical characteristics and outcome of patients with streptococcal toxic shock syndrome (TSS). Design: Observational. Setting: Medizinische Poliklinik, University of Bonn, Germany. Patients: Seven patients with direct or indirect evidence of streptococcal TSS. Intervention: In addition to conventional and supportive therapy, all patients received 2–3 single doses of C1-esterase inhibitor totaling 6,000–10,000 U within the first 24 h after admission. Measurements and results: All patients developed fulminant septic shock, multiorgan failure and/or capillary leak syndrome and necrotizing fasciitis within 10–72 h following the onset of first symptoms. Between 1 and 4 days following administration of C1-esterase inhibitor, a marked shift of fluid from extravascular to intravascular compartments took place in all but one patient, accompanied by a transient intra-alveolar lung edema and rapidly decreasing need for adrenergic agents. Six of seven patients survived. Conclusions: These clinical observations in a small series of patients and the favorable outcome point towards a positive effect of early and high-dose administration of C1-esterase inhibitor as adjunctive therapy in streptococcal TSS. The possible mechanism involved may be the attenuation of capillary leak syndrome (CLS) via early inactivation of complement and contact systems. Controlled studies are needed to establish an improvement of the survival rates of patients with streptococcal TSS following administration of C1-esterase inhibitor.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s001340000654
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Improvement in Claudication After Angioplasty of Distal Ostial Collateral Stenosis in Patients with Long-Segment Occlusion of the Femoral Artery (2000)
    Springer
    CardioVascular & interventional radiology 23 (2000), S. 447-451 
    Details
    ISSN: 1432-086X
    Schlagwort(e): Key words: Peripheral arterial occlusive disease—Intermittent claudication—Angioplasty—Superficial femoral artery, long-segment occlusion—Distal ostial collateral stenosis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Purpose: To evaluate the angiographic and clinical effects of percutaneous transluminal angioplasty (PTA) of distal ostial collateral stenoses in patients with claudication and long-segment occlusion of the superficial femoral artery (SFA). Methods: In ten patients (9 men, 1 woman) with stable intermittent claudication due to chronic long-segment occlusion of the SFA a high-grade stenosis of the distal collateral ostium of the deep femoral artery to the popliteal artery were dilated. PTA was performed using popliteal artery access. Claudication distances on the treadmill and ankle-brachial pressure indices (ABI) at rest were analyzed before, 1 week, and 14 weeks after PTA. Results: Initial technical success was obtained in all patients. There were no significant periprocedural local complications. The initial mean claudication distance on the treadmill increased significantly from 107 ± 65 m to 306 ± 209 m (p 〈 0.01), the maximal claudication distance from 203 ± 128 m to 392 ± 167 m (p 〈 0.01). The mean ABI changed slightly but significantly (0.61 ± 0.08 vs. 0.64 ± 0.07; p 〈 0.05). Early follow-up after 14 weeks revealed no clinical deterioration. Conclusion: This new technique is considered helpful in patients with well-defined claudication and long-segment occlusion of the SFA.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002700010102
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    NAD(P)H quinone oxidoreductase 1 codon 609 polymorphism and its association to colorectal cancer (2000)
    Springer
    Archives of toxicology 73 (2000), S. 528-531 
    Details
    ISSN: 1432-0738
    Schlagwort(e): Key words NQO1 polymorphism ; Real-time PCR ; Colorectal cancer
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The present study used a rapid and single-step method for genotyping of NAD(P)H quinone oxidoreductase (NQO1) codon 609 polymorphism using real-time polymerase chain reaction (PCR)-analysis and subsequent melting curve analysis for the analysis of allelic distribution of NQO1. The design was a case control study of 323 Caucasians with colorectal cancer and 205 healthy controls. There was no difference in the frequencies of the mutated NQO1 allele (NQO1*2): 0.190 for control individuals and 0.195 for cancer patients, respectively (P=0.947). When this allelic distribution was further compared between non-smoking and smoking colorectal cancer patients, it appeared that the frequency of the wild-type allele NQO1*1 was higher in the smoking than in the non-smoking group [Odds ratio (OR), 0.434; 95% confidence interval (CI), 0.13–1.42]. This observation may suggest a protective role of the NQO1 wild-type allele in colon cancer susceptibility of individuals exposed to NQO1-inducing chemicals.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002040050004
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    Differential lusitropic responsiveness to β-adrenergic stimulation in rat atrial and ventricular cardiac myocytes (2000)
    Springer
    Pflügers Archiv 441 (2000), S. 78-87 
    Details
    ISSN: 1432-2013
    Schlagwort(e): β-Adrenergic stimulation Atria Calcium fluorescence Cardiac myocytes Cell contractility Phospholamban Relaxation SERCA2a
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract. Cardiac myocyte relaxation is brought about mainly through Ca2+ uptake into the sarcoplasmic reticulum (SR) by a Ca2+-ATPase isoform, SERCA2a. Its activity is modulated by another protein, phospholamban (PLB). The levels of both proteins differ in some mammals between atrial and ventricular myocardium and this may lead to differences in relaxation, especially under stimulatory conditions. At a concentration of 100 nM, the β-adrenergic agonist isoprenaline (ISO) accelerates the relaxation of rat papillary muscle more than that of the left atria (16.4 versus 4.0% hastening of time to 50% relaxation, respectively). Ventricular myocytes were 24.7% quicker in reaching 50% of their diastolic length after contraction when treated with ISO compared to atrial myocytes, which were only 3.6% faster. Ca2+ fluorescence transients were also abbreviated in ventricular compared to atrial myocytes exposed to ISO (41.9 versus 25.2% hastening of time to 50% peak Ca2+ respectively). Ca2+ uptake into ventricular SR vesicles was increased by 13% in the presence of protein kinase A while that into atrial SR vesicles remained unaffected. Western blotting analysis revealed 23% less SERCA2a protein, but 76% more PLB in ventricular compared to atrial tissue. We conclude that the distinct levels of SERCA2a and PLB in ventricular and atrial myocardium are responsible for the differential modulation of the relaxation process arising from β-adrenergic stimulation in single rat atrial and ventricular myocytes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004240000397
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  • 8
    Digitale Medien
    Digitale Medien
    Influence of sustained mechanical stress on Egr-1 mRNA expression in cultured human endothelial cells (2000)
    Springer
    Molecular and cellular biochemistry 210 (2000), S. 101-108 
    Details
    ISSN: 1573-4919
    Schlagwort(e): human endothelial cells ; mechanical stress ; immediate early genes ; protein kinase C ; calcium
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Abstract Restenosis after initially successful balloon angioplasty of coronary artery stenosis remains a major problem in clinical cardiology. Previous studies have identified pathogenetic factors which trigger cell proliferation and vascular remodeling ultimately leading to restenosis. Since there is evidence that endothelial cells adjacent to the angioplasty wound area synthesize factors which may initiate this process, we investigated the effects of mechanical stimulation on endothelial gene expression in vitro and focussed on the influence of sustained mechanical stress on expression of immediate early genes which have previously been shown to be induced in the vascular wall in vivo. Primary cultured human umbilical vein endothelial cells (HUVEC) and the human endothelial cell line EA.hy 926 were plated on collagen-coated silicone membranes and subjected to constant longitudinal stress of approximately 20% for 10 min to 6 h. Total RNA was isolated and the expression of the immediate early genes c-Fos and Egr-1 was studied by Northern blot analysis. We found a rapid upregulation c-Fos and Egr-1 mRNA which started at 10 min and reached its maxima at 30 min. HUVEC lost most of their stretch response after the third passage whereas immediate early gene expression was constantly in EA.hy 926 cells. Using specific inhibitors we investigated the contribution of several signal transduction pathways to stretch-activated Egr-1 mRNA expression. We found significant suppression of stretch-induced Egr-1 mRNA expression by protein kinase C (PKC) inhibition (p 〈 0.05) and by calcium depletion (EA.hy926, p 〈 0. 05; HUVEC, p = 0.063). No effect on stretch-activated Egr-1 mRNA expression was detected by inhibition of protein kinase A, blockade of stretch-activated cation channels or inhibition of microtubule synthesis. We conclude that sustained mechanical strain induces Egr-1 mRNA expression by PKC- and calcium-dependent mechanisms.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1007126218740
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  • 9
    Digitale Medien
    Digitale Medien
    Single bead parallel synthesis and screening (2000)
    Springer
    Molecular diversity 5 (2000), S. 111-116 
    Details
    ISSN: 1573-501X
    Schlagwort(e): combinatorial chemistry ; delivery microreactors ; drop-on-demand liquid ; miniaturization ; photolysis ; silicon wafer ; single bead synthesis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Microstructured silicon wafers were employed as miniaturizedsolid-phase reaction vessels as well as miniaturized microtiter plates. Employing piezoelectric drop-on-demand liquidjets, a combinatorial library of 256 Peptides was synthesizedon single beads. The synthesis protocol was associated to thelocation in the silicon nano-well arrangement. Products werephotolytically cleaved in the same well that was used forsynthesis and subsequently interrogated for thrombin inhibitionin a homogeneous competition assay. The assay procedure wasbased on drop-on-demand liquid delivery and laser inducedfluorescence imaging. The novel format proved useful for theintegration of both synthesis and screening into one platform,a prerequisite for an iterative, evolutionary approach towardsdrug discovery.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1016287827310
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  • 10
    Digitale Medien
    Digitale Medien
    Patient Medication Counseling – Patientenberatung zur Entlassungsmedikation (2000)
    Springer
    Medizinische Klinik 95 (2000), S. 548-551 
    Details
    ISSN: 1615-6722
    Schlagwort(e): Schlüsselwörter Compliance ; Entlassungsmedikation ; Beratung ; Klinischer Pharmazeut ; Key Words Compliance ; Discharge medication ; Counseling ; Clinical pharmacist
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Abstract Background: With discharge from hospital, the correct use of his drugs is the responsibility of the patient. The patient's compliance mainly affects the success of therapy. An essential requirement for good compliance is informing the patient properly about the purpose and correct use of his drugs. In the first pilot study in Germany on this subject, we investigated how the additional patient medication counseling by a clinical pharmacist prior to discharge improves the patient's knowledge of his drugs. Study Design: During a 10-week-period, 37 patients were randomly assigned to either an intervention group or a control group. Patients of the intervention group were verbally and in writing informed about the purpose and correct use of their drugs. The effect of the additional counseling was determined in both groups by a questionnaire at the time of discharge and a telephone interview 2 weeks later. Conclusion: Patient medication counseling by a clinical pharmacist prior to discharge improves the patient's knowledge of his drugs as an essential requirement of good compliance. Taking into consideration the economical consequences of noncompliance and the financial problems of the public health system it is advisable to establish this service in German hospitals.
    Notizen: Zusammenfassung Hintergrund: Mit der Entlassung aus dem Krankenhaus liegt die Verantwortung für die korrekte Einnahme der Medikamente beim Patienten. Seine Compliance ist entscheidend für den Therapieerfolg. Eine wesentliche Voraussetzung für gute Compliance ist die ausreichende Information des Patienten über Indikation und Einnahmemodalitäten seiner Medikamente. In einer Pilotstudie wurde erstmals für Deutschland kontrolliert untersucht, wie die zusätzliche Beratung des Patienten zu seiner Entlassungsmedikation durch einen klinischen Pharmazeuten das Wissen über seine Arzneimittel beeinflusst. Studiendesign:Über eine Zeitraum von zehn Wochen wurden 37 Patienten in eine Beratungs- und eine Kontrollgruppe randomisiert. Die Patienten der Beratungsgruppe wurden mündlich und schriftlich über Indikation und Einnahmemodalitäten informiert. Der Einfluss der Beratung auf das Wissen der Patienten wurden in beiden Gruppen mit Hilfe eines Fragebogens zum Zeitpunkt der Entlassung und eines Telefonats 14 Tage später untersucht. Schlußfolgerung: Die Beratung von Patienten zur Entlassungsmedikation durch einen Apotheker erhöht das Wissen des Patienten über seine Arzneimittel und damit eine wesentliche Voraussetzung für eine gute Compliance. Unter Berücksichtigung der ökonomischen Auswirkungen der Noncompliance und der begrenzten finanziellen Mittel im Gesundheitswesen ist die Einführung eines solchen Beratungsdienstes in Deutschland sinnvoll.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/PL00002061
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