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  • 1
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    Simulating Molecular Interactions of Carbon Nanoparticles with a Double-Stranded DNA Fragment (2015)
    Hindawi
    Details
    Publication Date: 2015-10-23
    Description: Molecular interactions between carbon nanoparticles (CNPs) and a double-stranded deoxyribonucleic acid (dsDNA) fragment were investigated using molecular dynamics (MD) simulations. Six types of CNPs including fullerenes (C60 and C70), () single-walled carbon nanotube (SWNT), () double-walled carbon nanotube (DWNT), graphene quantum dot (GQD), and graphene oxide quantum dot (GOQD) were studied. Analysis of the best geometry indicates that the dsDNA fragment can bind to CNPs through pi-stacking and T-shape. Moreover, C60, DWNT, and GOQD bind to the dsDNA molecules at the minor groove of the nucleotide, and C70, SWNT, and GQD bind to the dsDNA molecules at the hydrophobic ends. Estimated interaction energy implies that van der Waals force may mainly contribute to the mechanisms for the dsDNA-C60, dsDNA-C70, and dsDNA-SWNT interactions and electrostatic force may contribute considerably to the dsDNA-DWNT, dsDNA-GQD, and dsDNA-GOQD interactions. On the basis of the results from large-scale MD simulations, it was found that the presence of the dsDNA enhances the dispersion of C60, C70, and SWNT in water and has a slight impact on DWNT, GQD, and GOQD.
    Print ISSN: 2090-9063
    Topics: Chemistry and Pharmacology
    Published by Hindawi
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  • 2
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    Caffeoylquinic Acid Derivatives Extract of Erigeron multiradiatus Alleviated Acute Myocardial Ischemia Reperfusion Injury in Rats through Inhibiting NF-KappaB and JNK Activations (2016)
    Hindawi
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    Publication Date: 2016-07-20
    Description: Erigeron multiradiatus (Lindl.) Benth. has been used in Tibet folk medicine to treat various inflammatory diseases. The aim of this study was to investigate antimyocardial ischemia and reperfusion (I/R) injury effect of caffeoylquinic acids derivatives of E. multiradiatus (AE) in vivo and to explain underling mechanism. AE was prepared using the whole plant of E. multiradiatus and contents of 6 caffeoylquinic acids determined through HPLC analysis. Myocardial I/R was induced by left anterior descending coronary artery occlusion for 30 minutes followed by 24 hours of reperfusion in rats. AE administration (10, 20, and 40 mg/kg) inhibited I/R-induced injury as indicated by decreasing myocardial infarct size, reducing of CK and LDH activities, and preventing ST-segment depression in dose-dependent manner. AE decreased cardiac tissue levels of proinflammatory factors TNF-α and IL-6 and attenuated leukocytes infiltration. AE was further demonstrated to significantly inhibit I-κB degradation, nuclear translocation of p-65 and phosphorylation of JNK. Our results suggested that cardioprotective effect of AE could be due to suppressing myocardial inflammatory response and blocking NF-κB and JNK activation pathway. Thus, caffeoylquinic acids might be the active compounds in E. multiradiatus on myocardial ischemia and be a potential natural drug for treating myocardial I/R injury.
    Print ISSN: 0962-9351
    Electronic ISSN: 1466-1861
    Topics: Medicine
    Published by Hindawi
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  • 3
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    Advanced Fireworks Algorithm and Its Application Research in PID Parameters Tuning (2016)
    Hindawi
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    Publication Date: 2016-06-21
    Description: Proportional-Integral-Derivative (PID) controller is one of the most widely used controllers for its property of simplicity and practicability. In order to design high-quality performances PID controllers, an Advanced Fireworks (AFW) algorithm based on self-adaption principle and bimodal Gaussian function is proposed, which is built to optimize the PID controller by parameters tuning. Firstly, a compound index of optimization performance is formulated, and then the extremal optimization method of PID control system is proposed. Secondly, a PID parameters tuning model combined with AFW is built. At last, 5 typical transfer functions are simulated to obtain optimal parameters by AFW and contrast tuning method, such as Ziegler-Nichols method, Enhanced Fireworks (EFW) algorithm, and Particle Swarm Optimization (PSO). Simulation results show that AFW are effective and are easily implemented methods to solve PID control problems of different transfer functions.
    Print ISSN: 1024-123X
    Electronic ISSN: 1563-5147
    Topics: Mathematics , Technology
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  • 4
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    Attitude and Altitude Controller Design for Quad-Rotor Type MAVs (2013)
    Hindawi
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    Publication Date: 2013-05-10
    Description: Micro air vehicles (MAVs) have a wide application such as the military reconnaissance, meteorological survey, environmental monitoring, and other aspects. In this paper, attitude and altitude control for Quad-Rotor type MAVs is discussed and analyzed. For the attitude control, a new method by using three gyroscopes and one triaxial accelerometer is proposed to estimate the attitude angle information. Then with the approximate linear model obtained by system identification, Model Reference Sliding Mode Control (MRSMC) technique is applied to enhance the robustness. In consideration of the relatively constant altitude model, a Linear Quadratic Gaussian (LQG) controller is adopted. The outdoor experimental results demonstrate the superior stability and robustness of the controllers.
    Print ISSN: 1024-123X
    Electronic ISSN: 1563-5147
    Topics: Mathematics , Technology
    Published by Hindawi
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  • 5
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    Convergence of GAOR Iterative Method with Strictly α Diagonally Dominant Matrices (2011)
    Hindawi
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    Publication Date: 2011-11-16
    Description: We discuss the convergence of GAOR method for linear systems with strictly α diagonally dominant matrices. Moreover, we show that our results are better than ones of Darvishi and Hessari (2006), Tian et al. (2008) by using three numerical examples.
    Print ISSN: 1110-757X
    Electronic ISSN: 1687-0042
    Topics: Mathematics
    Published by Hindawi
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  • 6
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    A Coupled User Clustering Algorithm Based on Mixed Data for Web-Based Learning Systems (2015)
    Hindawi
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    Publication Date: 2015-08-18
    Description: In traditional Web-based learning systems, due to insufficient learning behaviors analysis and personalized study guides, a few user clustering algorithms are introduced. While analyzing the behaviors with these algorithms, researchers generally focus on continuous data but easily neglect discrete data, each of which is generated from online learning actions. Moreover, there are implicit coupled interactions among the data but are frequently ignored in the introduced algorithms. Therefore, a mass of significant information which can positively affect clustering accuracy is neglected. To solve the above issues, we proposed a coupled user clustering algorithm for Wed-based learning systems by taking into account both discrete and continuous data, as well as intracoupled and intercoupled interactions of the data. The experiment result in this paper demonstrates the outperformance of the proposed algorithm.
    Print ISSN: 1024-123X
    Electronic ISSN: 1563-5147
    Topics: Mathematics , Technology
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  • 7
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    A Combined Raman Spectroscopic and Thermogravimetric Analysis Study on Oxidation of Coal with Different Ranks (2015)
    Hindawi
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    Publication Date: 2015-11-24
    Description: Raman spectroscopy and nonisothermal thermogravimetric analysis (TGA) measurements have been reported for different rank coals (lignite, bituminous coal, and anthracite) and the relationship between the measurements was examined. It was found that the Raman spectra parameters can be used to characterize structure changes in the different rank coals, such as the band area ratios based on the curve-fitted results. Higher ranked coal was found to have higher values of and but lower values of , , , and . The oxidation properties of the coal samples were characterized by the reactivity indexes , , and from TGA data which were found to correlate well with the band area ratios of , , and . Based on these correlations, the Raman band area ratios were found to correlate with the oxidation activity of coal providing additional structural information which can be used to understand the changes in the TGA measurements.
    Print ISSN: 2090-8865
    Electronic ISSN: 2090-8873
    Topics: Chemistry and Pharmacology
    Published by Hindawi
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  • 8
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    Nanoparticles-Assisted Stem Cell Therapy for Ischemic Heart Disease (2015)
    Hindawi
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    Publication Date: 2015-12-30
    Description: Stem cell therapy has attracted increasing attention as a promising treatment strategy for cardiac repair in ischemic heart disease. Nanoparticles (NPs), with their superior physical and chemical properties, have been widely utilized to assist stem cell therapy. With the help of NPs, stem cells can be genetically engineered for enhanced paracrine profile. To further understand the fate and behaviors of stem cells in ischemic myocardium, imaging NPs can label stem cells and be tracked in vivo under multiple modalities. Besides that, NPs can also be used to enhance stem cell retention in myocardium. These facts have raised efforts on the development of more intelligent and multifunctional NPs for cellular application. Herein, an overview of the applications of NPs-assisted stem cell therapy is given. Key issues and future prospects are also critically addressed.
    Electronic ISSN: 1687-9678
    Topics: Medicine
    Published by Hindawi
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