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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 290 (1975), S. 35-47 
    ISSN: 1432-1912
    Keywords: Guinea Pig Atrial Muscle ; Ryanodine ; Ryanodine Steady-State Condition ; Post-Rest Potentiation ; Calcium Exchange
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of ryanodine and ryanodine steady-state condition (RSSC) on contractile-related calcium were examined in isolated guinea pig left atrial muscle. 1. RSSC is a specific irreversible condition occurring after a brief exposure to 1×10−7 M ryanodine, followed by washing. It is characterized by elimination of the contraction following a 10-sec rest interval (post-rest) and prolongation of the associated action potential duration (AP50%) from 78.9 to 160.8 msec with minimal alteration in steady-state tension development determined at 1 Hz. 2. Induction of RSSC with a ryanodine-bovine serum albumin conjugate produced similar alterations in post-rest contractile strength and action potential duration. 3. In the presence of 1×10−7 M ryanodine, guinea pig left atria exhibit a significant increase in total 45Ca efflux from two rapidly exchangeable compartments (compartment 1, t 1/2=1.58 min; compartment 2, t 1/2-8.20 min). 4. In atria loaded after the induction of RSSC, total 45Ca release was significantly reduced by 7.2% of the total exchange. 5. The 45Ca exchange space for RSSC atria was reduced from 23.22±0.81 to 19.85±1.22 ml per 100 g muscle without a significant reduction in the total exchange space. 6. From these results, it is concluded that the effects of low concentrations of ryanodine and RSSC are to alter the contractile calcium levels of the tissue, primarily from sarcolemmal membrane sites which regulate post-rest contractile strength and action potential duration.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of comparative physiology 169 (1991), S. 323-330 
    ISSN: 1432-1351
    Keywords: Habituation ; Contralateral sensitization ; Leaky integrator ; Rotation detectors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Fruitflies (Drosophila melanogaster) may respond with landing reactions in tethered flight to unilateral progressive motion of single vertical dark stripes. The response frequency to repeated unilateral stimulation has a characteristic time course, a fast increase followed by a slower decrease. This behaviour is explained by the habituation of the input channels to a leaky integrator. The half-life of the integrated signal is in the range of 1 s. ‘Contralateral sensitization’ (CoS) describes the sensitization of the landing response to unilateral stimuli by preceding contralateral stimulation. It acts by increasing the initial reactivity, which habituates. The effects of CoS are thus still obvious after 1 min of repetitive stimulation. CoS can effectively be mediated by movement stimuli as well as by flickering light. We also show that binocular rotation rather than unilateral back to front motion inhibits the landing response (in the monocular part of the visual field). The biological significance of the described temporal characteristics of the landing response system and their possible neuronal basis are discussed.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0948-5023
    Keywords: High-Temperature MD Simulations ; Confor-mational Analysis ; Porphyrin-Quinone Systems ; Photosynthesis Models
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Photoinduced electron transfer reactions play an important role in the primary step of the biological photosynthesis process. In an attempt to understand better the mechanism of the charge separation organic donor-acceptor molecules containing porphyrins and quinones were designed as photosynthesis models. In order to study the structure dependence of the photoinduced electron transfer twofold and fourfold bridged porphyrin-quinone systems with increasing donor-acceptor distance were synthesized (Figure 1) [1, 2, 3]. It was assumed that in these molecules the porphyrin and quinone should be linked in a rigid and well-defined orientation. To verify this assumption the conformational behavior of these systems was studied by high-temperature MD simulations in combination with conformational analysis of selected minimized structures [4, 5].
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0948-5023
    Keywords: Keywords: Protein-Carbohydrate interactions ; MD simulations ; Flexibility ; Sialyllactose ; Influenza A virus hemagglutinin ; Murine polyoma virus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The attachment of a virus to the host cell surface is influenced by enthalpic and entropic factors. A detailed evaluation of all possible energetic interactions including the effects of solvent molecules seems to be a promising way to gain deeper insights in the overall process of binding. Here we performed intensive molecular dynamics studies to compare the conformational space available for the unbound sialyllactose in aqueous solution and when complexed with influenza A hemagglutinin and the murine polyoma virus. In general the conformational freedom of sialyllactose is considerably reduced compared to the free state. Remarkably, two different conformations of the Siaα(2-3)Galβ glycosidic linkages are preferred (which are both populated in the free state) when complexed with either protein.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 271 (1952), S. 240-252 
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Es wird über eine neue Methode der Hernienplastik bei Inguinal- und Cruralhernien berichtet, wobei auf folgende 3 Momente besonders Wert gelegt wird: 1. Die sorgfältige Präparation des Bruchsackes und seine ordnungsgemäße Versorgung durch Verlagerung nach medial und oben nach vorheriger Torsion sind die wichtigen Voraussetzungen für die Dauerheilung der Leisten- und Schenkelhernien. 2. Die plastische Wiederherstellung der Bauchwand im Bereiche des Trig. ing. ist grundsätzlich nach den vonBassini aufgestellten Richtlinien vorzunehmen, das Vorgehen wird dabei beim Einzelfall durch die Verhältnisse im Leistenkanal bestimmt. Als ganz besonders wichtig wird bei medialer Leistenhernie und bei cruraler Hernie betrachtet, das Schambeinperiost in die Naht mitzufassen. 3. Der Bruchsack wird bei allen großen Hernien der besprochenen Bruchformen zur Vermehrung der Bauchwandschichten verwendet. Dieser erhöht die Verschlußfestigkeit der Bruchpforte und schützt die Muskulatur vor Quetschung durch das Nahtmaterial.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 274 (1953), S. 159-169 
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenjassung Es wird versucht, den Ursachen für das häufig beobachtete Versagen einer einseitigen Calciumbehandlung bei Demineralisation der Knochen, in erster Linie bei verzögerter Frakturenheilung, nachzugehen und die heutige Auffassung von dem normalen und gestörten Mineralstoffwechsel des Skeletsystems zu resümieren. Daraus wird die Erkenntnis abgeleitet, daß es nicht genüge, bei derartigen Zuständen nur einen einzigen Ossifikationsfaktor zu ersetzen, sondern im Sinne einer spezifisehen Organotherapie die Darreichung eines Knochenvollpräparates nottue. Als geeignetes Präparat wurde bei 14 KrankenOssopan angewendet und damit ein regelmäßiger Erfolg erzielt, der nicht nur die deduzierten Erwartungen voll erfüllt hat, sondern diese Darreichung auch in Zukunft und auf breiter Basis empfiehlt.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurocytology 10 (1981), S. 805-818 
    ISSN: 1573-7381
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A quantitative light microscopic analysis of the ventral grey matter in the lumbar spinal cord of homozygous nude (nu/nu) and heterozygous (nu/+) mice was performed to determine the possible contribution of lymphocytes to normal C.N.S. tissue. If lymphocytes were present in the neuropil, they could be mistaken for neuroglial cells. Athymic nude mice offer a good model, since they lack T-lymphocytes and symptoms of neurological involvement. Mean cell counts from 1 μm sections were tested by analysis of variance. There were no strain differences for the area and number of neurons. The total neuroglial cell count was also similar, but the number of oligodendrocytes decreased 28%, astrocytes increased 51% and microglia were unchanged in the nude compared with the heterozygous mouse. There were no qualitative differences at the ultrastructural level among the neuroglia of either strain. Either the genetic defect retards and alters neuroglial cell development, or some of the small, round dark nuclei belong to lymphocytes, which have earlier migrated into the C.N.S. parenchyma. Lymphocytes could then participate in a cell-mediated immune response with brain macrophages, which are thought to be primarily derived from mononuclear leukocytes.
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Medical & biological engineering & computing 16 (1978), S. 118-120 
    ISSN: 1741-0444
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
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  • 9
    Publication Date: 2021-02-08
    Description: The ultimate, possibly geodynamic control and potential impact of changes in circulation activity and salt discharge of Mediterranean outflow waters (MOW) on Atlantic meridional overturning circulation have formed long-standing objectives in paleoceanography. Late Pliocene changes in the distal advection of MOW were reconstructed on orbital timescales for northeast Atlantic DSDP/ODP sites 548 and 982 off Brittany and on Rockall Plateau, supplemented by a proximal record from Site U1389 west off Gibraltar, and compared to Western Mediterranean surface and deep-water records of Alboran Sea Site 978. From ~3.43 to 3.3 Ma, MOW temperatures and salinities form a prominent rise by 2–4 °C and ~3 psu, induced by a preceding and coeval rise in sea surface and deep-water salinity and increased summer aridity in the Mediterranean Sea. We speculate that these changes triggered an increased MOW flow and were ultimately induced by a persistent 2.5 °C cooling of Indonesian Through-Flow waters. The temperature drop resulted from the northward drift of Australia that crossed a threshold value near 3.6–3.3 Ma and led to a large-scale cooling of the eastern subtropical Indian Ocean and in turn, to a reduction of African monsoon rains. Vice versa, we show that the distinct rise in Mediterranean salt export after ~3.4 Ma induced a unique long-term rise in the formation of Upper North Atlantic Deep Water, that followed with a phase lag of ~100 ky. In summary, we present evidence for an interhemispheric teleconnection of processes in the Indonesian Gateways, the Mediterranean and Labrador Seas, jointly affecting Pliocene climate.
    Type: Article , PeerReviewed
    Format: text
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  • 10
    Publication Date: 2021-04-23
    Description: Meteor Cruise M121 was dedicated to the investigation of the distribution of dissolved and particulate trace metals and their isotopic compositions (TEIs) in the full water column of the Angola Basin and the northernmost Cape Basin. A key aim was to determine the driving factors for the observed distributions, which includes the main external inputs, as well as internal cycling and ocean circulation. The research program of the cruise is official part of the international GEOTRACES program (www.geotraces.org) and cruise M121 corresponds to GEOTRACES cruise GA11. Subject of the cruise was the trace metal clean and contamination-free sampling of waters and particulates for subsequent analyses of the TEIs in the home laboratories of the national and international participants. Besides a standard rosette for the less contaminant prone metals, trace metal clean sampling was realized by using for the first time a new dedicated, coated trace metal clean rosette equipped with Teflon-coated GO-FLO bottles operated via a plastic coated cable from a mobile winch of GEOMAR Kiel. The particulate samples were collected under trace metal clean conditions using established in-situ pump systems operated from Meteor’s Aramid line. The cruise track led from Walvis Bay northwards along the West African margin until 3°S, then turned west until the Zero Meridian, which was followed southwards until 30°S. Then the cruise track turned east again until the Namibian margin was reached and then completed the near shore track northwards until Walvis Bay. The track crossed areas of major external inputs including dust from the Namib Desert and exchange with the west African continental margin and with the oxygen depleted shelf sediments of the Benguela upwelling, as well as with the plume of the Congo outflow, that was followed from its mouth northwards. Our investigations of internal cycling included the extremely high productivity associated with the Benguela Upwelling and the elevated productivity of the Congo plume contrasting with the extremely oligotrophic waters of the southeastern Atlantic Gyre. The links between TEI biogeochemistry and the nitrogen cycle forms an important aspect of our study. The major water masses contributing the Atlantic Meridional Overturning Circulation were sampled in order to investigate if particular TEI signatures are suitable as water mass tracers, in particular near the ocean margin and in the restricted deep Angola Basin. A total of 51 full water column stations were sampled for the different dissolved TEIs, which were in most cases accompanied by sampling for particulates and radium isotopes using the in-situ pumps. In addition, surface waters were continuously sampled under trace metal clean conditions using a towed fish and aerosol and rain samples were continuously collected.
    Type: Report , NonPeerReviewed
    Format: text
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