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Online-Ressource

Environmental Sustainability in Building Design and Construction (2021)

Wang, Xiaoming [VerfasserIn]

Cham : Springer International Publishing | Cham : Imprint: Springer

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Schlagwort(e): Sustainable development. ; Buildings—Design and construction. ; Building. ; Construction. ; Engineering, Architectural. ; Climate change. ; Sustainable architecture. ; Environmental management.

Beschreibung / Inhaltsverzeichnis: Chapter 1-Introduction -- Chapter 2-National and international developments -- Chapter 3-Climate change and built environment -- Chapter 4-Energy and carbon emission -- Chapter 5-Materials and water -- Chapter 6-Sustainable waste management -- Chapter 7-Resilience and adaptation in buildings -- Chapter 8-Sustainable building design -- Chapter 9-Urban sustainable developments -- Chapter 10-Regional sustainable developments.

Materialart: Online-Ressource

Seiten: 1 Online-Ressource(X, 175 p. 80 illus., 64 illus. in color.)

Ausgabe: 1st ed. 2021.

ISBN: 9783030762315

URL: https://doi.org/10.1007/978-3-030-76231-5

DOI: 10.1007/978-3-030-76231-5

Sprache: Englisch

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Digitale Medien

Phosphorylation of HMG-I by Protein Kinase C Attenuates Its Binding Affinity to the Promoter Regions of Protein Kinase C γ and Neurogranin/RC3 Genes (2000)

Xiao, Dian-Mo ; Pak, Jhang Ho ; Wang, Xiaoming ; [weitere]

Oxford UK : Blackwell Science Ltd

Journal of neurochemistry 74 (2000), S. 0

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ISSN: 1471-4159

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: Abstract: A 20-kDa DNA-binding protein that binds the AT-rich sequences within the promoters of the brain-specific protein kinase C (PKC) γ and neurogranin/RC3 genes has been characterized as chromosomal nonhistone high-mobility-group protein (HMG)-I. This protein is a substrate of PKC α, β, γ, and δ but is poorly phosphorylated by PKC ε and ζ. Two major (Ser44 and Ser64) and four minor phosphorylation sites have been identified. The extents of phosphorylation of Ser44 and Ser64 were 1:1, whereas those of the four minor sites all together were 〈30% of the major one. These PKC phosphorylation sites are distinct from those phosphorylated by cdc2 kinase, which phosphorylates Thr53 and Thr78. Phosphorylation of HMG-I by PKC resulted in a reduction of DNA-binding affinity by 28-fold as compared with 12-fold caused by the phosphorylation with cdc2 kinase. HMG-I could be additively phosphorylated by cdc2 kinase and PKC, and the resulting doubly phosphorylated protein exhibited a 〉 100-fold reduction in binding affinity. The two cdc2 kinase phosphorylation sites of HMG-I are adjacent to the N terminus of two of the three predicted DNA-binding domains. In comparison, one of the major PKC phosphorylation sites, Ser64, is adjacent to the C terminus of the second DNA-binding domain, whereas Ser44 is located within the spanning region between the first and second DNA-binding domains. The current results suggest that phosphorylation of the mammalian HMG-I by PKC alone or in combination with cdc2 kinase provides an effective mechanism for the regulation of HMG-I function.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1046/j.1471-4159.2000.0740392.x

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Digitale Medien

Two new carnivores from an unusual late Tertiary forest biota in eastern North America (2004)

Wallace, Steven C. ; Wang, Xiaoming

[s.l.] : Macmillian Magazines Ltd.

Nature 431 (2004), S. 556-559

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] Late Cenozoic terrestrial fossil records of North America are biased by a predominance of mid-latitude deposits, mostly in the western half of the continent. Consequently, the biological history of eastern North America, including the eastern deciduous forest, remains largely hidden. ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nature02819

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