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  • 1
    Electronic Resource
    Electronic Resource
    Melbourne, Australia : Blackwell Science Pty
    Clinical and experimental pharmacology and physiology 28 (2001), S. 0 
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. It has been suggested that calcitonin gene-related peptide (CGRP) is involved in the protection provided by ischaemic preconditioning in rat hearts and that ischaemic preconditioning is absent in diabetic rat hearts.2. In the present study, we tested the relationship between sensory nerve function and ischaemic preconditioning in diabetic rats.3. In 4- and 8-week diabetic rats and age-matched non- diabetic controls, 30 min global ischaemia and 40 min reperfusion caused a significant decrease in cardiac function and a marked increase in creatine kinase (CK) release. Ischaemic preconditioning, by three cycles of 5 min ischaemia and 5 min reperfusion, improved the recovery of cardiac function and decreased CK release during reperfusion in 4-week diabetic rat hearts. However, the cardioprotection afforded by ischaemic preconditioning was lost in 8-week diabetic rat hearts. Pretreatment with CGRP for 5 min also significantly improved the recovery of cardiac function and decreased CK release in rats subjected to 4 or 8 weeks of diabetes.4. The content of CGRP in the coronary effluent during ischaemic preconditioning was significantly increased in 4-week diabetic rat hearts (P 〈 0.05). However, only a slight increase in the release of CGRP was shown in 8-week diabetic rat hearts (P 〉 0.05).5. In summary, the present results suggest that the protection afforded by ischaemic preconditioning is attenuated in diabetic rats and that the change may be related to the reduction in CGRP release in diabetic rat hearts.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 443 (2006), S. 324-328 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] El Niño, the most prominent climate fluctuation at seasonal-to-interannual timescales, has long been known to have a remote impact on climate variability in the tropical Atlantic Ocean, but a robust influence is found only in the northern tropical Atlantic region. Fluctuations in the ...
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 385 (1997), S. 516-518 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In some respects, the tropical Atlantic Ocean is similar to the tropical Pacific, having, for example, an equatorial cold tongue of sea surface temperature just south of the Equator, and the northeasterly and southeasterly trade winds converging in the Inter-tropical Convergence Zone (ITCZ) north ...
    Type of Medium: Electronic Resource
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  • 4
    Publication Date: 2019-09-23
    Description: Subtropical western boundary currents are warm, fast-flowing currents that form on the western side of ocean basins. They carry warm tropical water to the mid-latitudes and vent large amounts of heat and moisture to the atmosphere along their paths, affecting atmospheric jet streams and mid-latitude storms, as well as ocean carbon uptake1, 2, 3, 4. The possibility that these highly energetic currents might change under greenhouse-gas forcing has raised significant concerns5, 6, 7, but detecting such changes is challenging owing to limited observations. Here, using reconstructed sea surface temperature datasets and century-long ocean and atmosphere reanalysis products, we find that the post-1900 surface ocean warming rate over the path of these currents is two to three times faster than the global mean surface ocean warming rate. The accelerated warming is associated with a synchronous poleward shift and/or intensification of global subtropical western boundary currents in conjunction with a systematic change in winds over both hemispheres. This enhanced warming may reduce the ability of the oceans to absorb anthropogenic carbon dioxide over these regions. However, uncertainties in detection and attribution of these warming trends remain, pointing to a need for a long-term monitoring network of the global western boundary currents and their extensions.
    Type: Article , PeerReviewed
    Format: text
    Format: text
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