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  • AMER GEOPHYSICAL UNION  (1)
  • BioMed Central  (1)
  • 1
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    AMER GEOPHYSICAL UNION
    In:  EPIC3JGR Atmosphere, AMER GEOPHYSICAL UNION, 125(16), ISSN: 2169-8996
    Publikationsdatum: 2020-09-14
    Beschreibung: An abundance of evidence indicates that the tropics are expanding. Despite many attempts to decipher the cause, the underlying dynamical mechanism driving tropical expansion is still not entirely clear. Here, based on observations, multimodel simulations from the Coupled Model Intercomparison Project phase 5 (CMIP5) and purposefully designed numerical experiments, the variations and trends of the tropical width are explored from a regional perspective. We find that the width of the tropics closely follows the displacement of oceanic midlatitude meridional temperature gradients (MMTG). Under global warming, as a first‐order response, the subtropical ocean experiences more surface warming because of the mean Ekman convergence of anomalously warm water. The enhanced subtropical warming, which is partially independent of natural climate oscillations, such as the Pacific Decadal Oscillation, leads to poleward advance of the MMTG and drives the tropical expansion. Our results, supported by both observations and model simulations, imply that global warming may have already significantly contributed to the ongoing tropical expansion, especially over the ocean‐dominant Southern Hemisphere.
    Repository-Name: EPIC Alfred Wegener Institut
    Materialart: Article , isiRev
    Format: application/pdf
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Publikationsdatum: 2013-11-13
    Beschreibung: Background: An animal model for HBV that more closely approximates the disease in humans is needed. The tree shrew (Tupaia belangeri) is closely related to primates and susceptible to HBV. We previously established that neonatal tree shrews can be persistently infected with HBV in vivo, and here present a six year follow-up histopathological study of these animals. Methods: Group A consists of six tree shrews with persistent HBV infection, group B consists of three tree shrews with suspected persistent HBV infection, while group C consists of four tree shrews free of HBV infection. Serum and liver tissues samples were collected periodically from all animals. HBV antigen and HBV antibodies were detected by ELISA and/or TRFIA. HBV DNA in serum and in liver biopsies was measured by FQ-PCR. Liver biopsies were applied for general histopathologic observation and scoring, immunohistochemical detections of HBsAg and HBcAg, and ultrastructural observation with electron microscope technique. Results: Hydropic, fatty and eosinophilic degeneration of hepatocytes, lymphocytic infiltration and hyperplasia of small bile ducts in the portal area were observed in group A. One animal infected with HBV for over six years showed multiple necrotic areas which had fused to form bridging necrosis and fibrosis, and megalocytosis. The hepatic histopathological scores of group A were higher than those of group B and C. The histopathological score correlated positively with the duration of infection. Conclusions: Hepatic histopathological changes observed in chronically HBV-infected tree shrews are similar to those observed in HBV-infected humans. The tree shrew may represent a novel animal model for HBV infection.
    Digitale ISSN: 1743-422X
    Thema: Medizin
    Publiziert von BioMed Central
    Standort Signatur Einschränkungen Verfügbarkeit
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