ISSN:
1432-1831
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Regimental intravenous injections of counter-ion complexes consisting of a group A streptococcal lipoteichoic acid and methylated bovine serum albumin given as a stabilized water-in-oil double emulsion elicited strong antibody responses in rabbits to teichoic acid accompanied by weak to nonexistent humoral responses to the protein; hyperimmunization with these complexes resulted in nephropathy associated with the formation of renal casts, the presence of proteinuria, and kidney swelling. When rabbits were immunized with the complex and then later challenged with soluble, non-complexed and non-immunogenic teichoic acid alone, teichoic acid, antibody, and complement were demonstrable in the glomeruli. This suggested that a humoral immune response directed towards the teichoic acid could lead to a renal dysfunction and that teichoic acid, under certain circumstances, could play some role in immune-dependent pathogenesis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02120810
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