ISSN:
1440-1681
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
b1. The effects of central administration of met-enkephalin, leu-enkephalin, the enkephalin analogue FK-33824 and the opiate antagonist naloxone on plasma concentration of adrenocorticotrophic hormone (ACTH) were examined in conscious sheep.2. Intracerebroventricular infusion of met-enkephalin and FK-33824 significantly decreased the basal plasma concentration of ACTH.3. Intracerebroventricular infusion of FK-33824 inhibited the haemorrhage-induced increase in plasma concentration of ACTH.4. Intracerebroventricular infusion of naloxone attenuated the central inhibition of plasma concentration of ACTH induced by FK-33824, but intravenous infusion of naloxone had no effect on the reduction in plasma concentration of ACTH induced by FK-33824.5. These studies suggest that in sheep met-enkephalin may play a central inhibitory role in the control of ACTH secretion.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1440-1681.1988.tb01029.x
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