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  • 2015-2019  (1)
  • 1985-1989  (3)
Publikationsart
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Jahr
  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Cancer immunology immunotherapy 21 (1986), S. 156-160 
    ISSN: 1432-0851
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Natural killer (NK) cell activity was generated in the spleen of C3H/HeN mice by i.p. administration of poly I:C, while i.p. injection of BCG primarily promoted the generation of NK-like cells in peritoneal exudates (PE). A single injection of 10 mg of BCG 9 days before s.c. challenge with the MBT-2 murine bladder cancer was found to induce a 45% protection against tumor take. However, a single injection of 100 μg poly I:C 16 h before tumor cell challenge did not protect the animals against tumor take. Intratumoral injection of either PE cells from BCG-immunized or spleen cells from poly I:C-treated mice into mice developing tumor, was capable of suppressing tumor growth in vivo. The mean tumor diameters of these two experimental groups of animals on day 40 were significantly smaller (P〈0.005) than in the controls, and they survived approximately 10 days longer than the controls. Since this in vivo tumor suppressive effect by the lymphoid cell population correlated with the increase in NK-like cell activity assayed in vitro, and most of the adherent cells had been removed before injection, it is suggested that the antitumor function of the lymphoid cell population may be mostly due to the presence of “activated” NK or NK-like cells. These results support the concept of NK therapy for cancer.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    ISSN: 1573-6717
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin , Psychologie
    Notizen: Abstract Although there are psychogenic consequences of impotence for all impotent men, it is assumed that the psychogenic causes of impotence will only be evident in those men diagnosed as psychogenically impotent. Research into the psychogenic causes of impotence has been sparse. We developed a model of psychogenic impotence, and compared a group of organically impotent men and a group of psychogenically impotent men. Ninety subjects were selected from those referred to our multi-disciplinary sexual dysfunction clinic. It was hypothesised that psychogenically impotent men would score higher in the categories of problems with sexuality, interactional problems, lovemaking and relationship problems, companionship, friendship and partnership problems, problems in the family situation, and life stresses: and, that organically impotent men would score higher in the health problems category. The results suggested that interactional problems between patient and partner were common to both diagnostic groups, and that in all other categories (with the exception of health problems) psychogenically impotent men experienced more difficulty (p〈.05). Organically impotent men, as expected, exhibited more health problems (p〈.05); however, a large number of psychogenically impotent patients suffered from the same health problems. It was suggested that some psychogenically impotent men suffered from an insidious organic deterioration which was undectable at the time of diagnosis, and that with the progress of time, the diagnosis of some of these patients might change to organic impotence.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Springer
    World journal of urology 3 (1986), S. 209-214 
    ISSN: 1433-8726
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Bacillus Calmette-Guérin (BCG) has achieved an important role in the prophylaxis and treatment of superficial bladder cancer. It has been found effective in the prevention of recurrences after endoscopic surgery as well as in the treatment of residual tumors. The most dramatic responses have been consistently demonstrated in the treatment of carcinoma in situ. Recent experience suggests that prolongation of treatment beyond the 6 weeks advocated in early protocols, significantly increases the anti-tumor activity of BCG. The side effects of intravesical administration of the vaccine are, in the vast majority of patients, well-tolerated, minimal and self-limiting. No permanent functional or structural damage of the bladder has been observed. The effectiveness of BCG is primarily dependent on the strain used as well as the dose, duration and frequency of its administration.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Publikationsdatum: 2017-06-14
    Beschreibung: BACKGROUND Relatively few studies have analyzed the mortality of follicular lymphoma (FL) patients in comparison with a sex- and age-matched general population. This study analyzed the overall survival (OS) of patients with FL and compared their survival with the expected survival of a general population. METHODS Patients diagnosed with FL were prospectively enrolled from 1980 to 2013. Standardized mortality ratios (SMRs) were obtained from yearly sex- and age-specific mortality rates in Spain, and OS was compared with age- and sex-matched general population data. RESULTS A total of 1074 patients with newly diagnosed FL were enrolled. The median OS was 231 months (95% confidence interval [CI], 195-267 months). Event-free survival at 12 months (EFS12) and event-free survival at 24 months (EFS24) were associated with an increased probability of early death, with an SMR of 10.27 (95% CI, 8.26-12.77) for EFS12. The overall SMR, including all causes of death, was 2.55 (95% CI, 2.23-2.92), and it was higher for women (SMR, 3.02; 95% CI, 2.48-3.67) and young adults (SMR, 6.01; 95% CI, 3.13-11.55). More than 10 years after the diagnosis, mortality rates for FL patients were lower than those for the general population (SMR, 0.47; 95% CI, 0.28-0.78). When FL was excluded as a cause of death, the overall SMR was 1.35 (95% CI, 1.11-1.65) without a statistically significant mortality increase in the 〉60-year-old group in comparison with age- and sex-matched general population data. More than 15% of the patients included in the study (n = 158) had more than 10 years of follow-up. CONCLUSIONS EFS12 and EFS24 predict an early increase in mortality. The long-term SMR, over the course of 10 years of follow-up, shows that patients with FL have a risk of dying similar to that of a sex- and age-matched general population. Cancer 2017 . © 2017 American Cancer Society .
    Print ISSN: 0008-543X
    Digitale ISSN: 1097-0142
    Thema: Biologie , Medizin
    Publiziert von Wiley-Blackwell im Namen von The American Cancer Society.
    Standort Signatur Einschränkungen Verfügbarkeit
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