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  • 1
    Online Resource
    Online Resource
    Oxford :Taylor & Francis Group,
    Keywords: Glaciers. ; Electronic books.
    Description / Table of Contents: A new edition of the classic textbook for all students of glaciation.
    Type of Medium: Online Resource
    Pages: 1 online resource (817 pages)
    Edition: 2nd ed.
    ISBN: 9781444128390
    DDC: 551.31
    Language: English
    Note: Cover -- Half Title -- Title Page -- Copyright Page -- Table of Contents -- Preface to the First Edition -- Preface to the Second Edition -- Acknowledgements -- Part One Glaciers -- 1 Introduction -- 1.1 Glacier systems -- 1.1.1 Mass balance -- 1.1.2 Meltwater -- 1.1.3 Glacier motion -- 1.1.4 Glaciers and sea-level change -- 1.1.5 Erosion and debris transport -- 1.1.6 Glacial sediments, landforms and landscapes -- 1.2 Glacier morphology -- 1.2.1 Ice sheets and ice caps -- 1.2.2 Glaciers constrained by topography -- 1.2.3 Ice shelves -- 1.3 Present distribution of glaciers -- 1.3.1 Influence of latitude and altitude -- 1.3.2 Influence of aspect, relief and distance from a moisture source -- 1.4 Past distribution of glaciers -- 1.4.1 'Icehouse' and 'greenhouse' worlds -- 1.4.2 Cenozoic glaciation -- 2 Snow, Ice and Climate -- 2.1 Introduction -- 2.2 Surface energy balance -- 2.2.1 Changes of state and temperature -- 2.2.2 Shortwave radiation -- 2.2.3 Longwave radiation -- 2.2.4 Sensible and latent heat: turbulent fluxes -- 2.2.5 Energy supplied by rain -- 2.2.6 Why is glacier ice blue? -- 2.3 Ice temperature -- 2.3.1 The melting point of ice -- 2.3.2 Controls on ice temperature -- 2.3.3 Thermal structure of glaciers and ice sheets -- 2.4 Processes of accumulation and ablation -- 2.4.1 Snow and ice accumulation -- 2.4.2 Transformation of snow to ice -- 2.4.3 Melting of snow and ice -- 2.4.4 Sublimation and evaporation -- 2.4.5 The influence of debris cover -- 2.5 Mass balance -- 2.5.1 Definitions -- 2.5.2 Measurement of mass balance -- 2.5.3 Annual mass balance cycles -- 2.5.4 Mass balance gradients -- 2.5.5 The equilibrium line -- 2.5.6 Glaciation levels or glaciation thresholds -- 2.5.7 Glacier sensitivity to climate change -- 2.6 Glacier-climate interactions -- 2.6.1 Effects of glaciers and ice sheets on the atmosphere -- 2.7 Ice cores. , 2.7.1 Ice coring programmes -- 2.7.2 Stable isotopes -- 2.7.3 Ancient atmospheres: the gas content of glacier ice -- 2.7.4 Solutes and particulates -- 3 Glacier Hydrology -- 3.1 Introduction -- 3.2 Basic concepts -- 3.2.1 Water sources and routing -- 3.2.2 Hydraulic potential -- 3.2.3 Resistance to flow -- 3.2.4 Channel wall processes: melting, freezing and ice deformation -- 3.3 Supraglacial and englacial drainage -- 3.3.1 Supraglacial water storage and drainage -- 3.3.2 Englacial drainage -- 3.4 Subglacial drainage -- 3.4.1 Subglacial channels -- 3.4.2 Water films -- 3.4.3 Linked cavity systems -- 3.4.4 Groundwater flow -- 3.4.5 Water at the ice-sediment interface -- 3.5 Glacial hydrological systems -- 3.5.1 Temperate glaciers -- 3.5.2 Polythermal glaciers -- 3.5.3 Modelling glacial hydrological systems -- 3.6 Proglacial runoff -- 3.6.1 Seasonal and shorter-term cycles -- 3.6.2 Runoff and climate change -- 3.7 Glacial lakes and outburst floods -- 3.7.1 Introduction -- 3.7.2 Moraine-dammed lakes -- 3.7.3 Ice-dammed lakes -- 3.7.4 Icelandic subglacial lakes -- 3.7.5 Estimating GLOF magnitudes -- 3.8 Life in glaciers -- 3.8.1 Supraglacial ecosystems -- 3.8.2 Subglacial ecosystems -- 3.9 Glacier hydrochemistry -- 3.9.1 Overview -- 3.9.2 Snow chemistry -- 3.9.3 Chemical weathering processes -- 3.9.4 Subglacial chemical weathering -- 3.9.5 Proglacial environments -- 3.9.6 Rates of chemical erosion -- 4 Processes of Glacier Motion -- 4.1 Introduction -- 4.2 Stress and strain -- 4.2.1 Stress -- 4.2.2 Strain -- 4.2.3 Rheology: stress-strain relationships -- 4.2.4 Force balance in glaciers -- 4.3 Deformation of ice -- 4.3.1 Glen's Flow Law -- 4.3.2 Crystal fabric, impurities and water content -- 4.3.3 Ice creep velocities -- 4.4 Sliding -- 4.4.1 Frozen beds -- 4.4.2 Sliding of wet-based ice -- 4.4.3 Glacier-bed friction -- 4.4.4 The role of water. , 4.5 Deformable beds -- 4.5.1 The Boulton-Hindmarsh model -- 4.5.2 Laboratory testing of subglacial tills -- 4.5.3 Direct observations of deformable glacier beds -- 4.5.4 Rheology of subglacial till -- 4.6 Rates of basal motion -- 4.6.1 'Sliding laws' -- 4.6.2 Local and non-local controls on ice velocity -- 4.7 Crevasses and other structures: strain made visible -- 4.7.1 Crevasses -- 4.7.2 Crevasse patterns -- 4.7.3 Layering, foliation and related structures -- 5 Glacier Dynamics -- 5.1 Introduction -- 5.2 Understanding glacier dynamics -- 5.2.1 Balance velocities -- 5.2.2 Deviations from the balance velocity -- 5.2.3 Changes in ice thickness: continuity -- 5.2.4 Thermodynamics -- 5.3 Glacier models -- 5.3.1 Overview -- 5.3.2 Equilibrium glacier profiles -- 5.3.3 Time-evolving glacier models -- 5.4 Dynamics of valley glaciers -- 5.4.1 Intra-annual velocity variations -- 5.4.2 Multi-annual variations -- 5.5 Calving glaciers -- 5.5.1 Flow of calving glaciers -- 5.5.2 Calving processes -- 5.5.3 'Calving laws' -- 5.5.4 Advance and retreat of calving glaciers -- 5.6 Ice shelves -- 5.6.1 Mass balance of ice shelves -- 5.6.2 Flow of ice shelves -- 5.6.3 Ice shelf break-up -- 5.7 Glacier surges -- 5.7.1 Overview -- 5.7.2 Distribution of surging glaciers -- 5.7.3 Temperate glacier surges -- 5.7.4 Polythermal surging glaciers -- 5.7.5 Surge mechanisms -- 6 The Greenland and Antarctic Ice Sheets -- 6.1 Introduction -- 6.2 The Greenland Ice Sheet -- 6.2.1 Overview -- 6.2.2 Climate and surface mass balance -- 6.2.3 Ice sheet flow -- 6.2.4 Ice streams and outlet glaciers -- 6.3 The Antarctic Ice Sheet -- 6.3.1 Overview -- 6.3.2 Climate and mass balance -- 6.3.3 Flow of inland ice -- 6.3.4 Ice streams -- 6.3.5 Hydrology and subglacial lakes -- 6.3.6 Ice stream stagnation and reactivation -- 6.3.7 Stability of the West Antarctic Ice Sheet. , 7 Glaciers and Sea-Level Change -- 7.1 Introduction -- 7.2 Causes of sea-level change -- 7.2.1 Overview -- 7.2.2 Glacio-eustasy and global ice volume -- 7.2.3 Glacio-isostasy and ice sheet loading -- 7.3 Sea-level change over glacial-interglacial cycles -- 7.3.1 Ice sheet fluctuations and eustatic sea-level change -- 7.3.2 Sea-level histories in glaciated regions -- 7.4 Glaciers and recent sea-level change -- 7.4.1 Recorded sea-level change -- 7.4.2 Global glacier mass balance -- 7.5 Future sea-level change -- 7.5.1 IPCC climate and sea-level projections -- 7.5.2 Predicting the glacial contribution to sea-level change -- Part Two Glaciation -- 8 Erosional Processes, Forms and Landscapes -- 8.1 Introduction -- 8.2 Subglacial erosion -- 8.2.1 Rock fracture: general principles -- 8.2.2 Abrasion -- 8.2.3 Quarrying -- 8.2.4 Erosion beneath cold ice -- 8.2.5 Erosion of soft beds -- 8.3 Small-scale erosional forms -- 8.3.1 Striae and polished surfaces -- 8.3.2 Rat tails -- 8.3.3 Chattermarks, gouges and fractures -- 8.3.4 P-forms -- 8.4 Intermediate-scale erosional forms -- 8.4.1 Roches moutonnées -- 8.4.2 Whalebacks and rock drumlins -- 8.4.3 Crag and tails -- 8.4.4 Channels -- 8.5 Large-scale erosional landforms -- 8.5.1 Rock basins and overdeepenings -- 8.5.2 Basins and overdeepenings in soft sediments -- 8.5.3 Troughs and fjords -- 8.5.4 Cirques -- 8.5.5 Strandflats -- 8.6 Landscapes of glacial erosion -- 8.6.1 Areal scouring -- 8.6.2 Selective linear erosion -- 8.6.3 Landscapes of little or no glacial erosion -- 8.6.4 Alpine landscapes -- 8.6.5 Cirque landscapes -- 8.6.6 Continent-scale patterns of erosion -- 9 Debris Entrainment and Transport -- 9.1 Introduction -- 9.2 Approaches to the study of glacial sediments -- 9.2.1 The glacial debris cascade -- 9.2.2 Spatial hierarchies of sediments and landforms -- 9.3 Glacial debris entrainment. , 9.3.1 Supraglacial debris entrainment -- 9.3.2 Incorporation of debris into basal ice -- 9.4 Debris transport and release -- 9.4.1 Subglacial transport -- 9.4.2 High-level debris transport -- 9.4.3 Glacifluvial transport -- 9.5 Effects of transport on debris -- 9.5.1 Granulometry -- 9.5.2 Clast morphology -- 9.5.3 Particle micromorphology -- 10 Glacigenic Sediments and Depositional Processes -- 10.1 Introduction -- 10.2 Sediment description and classification -- 10.2.1 Sediment description -- 10.2.2 Deformation structures -- 10.2.3 Primary and secondary deposits -- 10.3 Primary glacigenic deposits (till) -- 10.3.1 Overview -- 10.3.2 Processes of subglacial till formation -- 10.3.3 Glacitectonite -- 10.3.4 Subglacial traction till -- 10.4 Glacifluvial deposits -- 10.4.1 Terminology and classification of glacifluvial sediments -- 10.4.2 Plane bed deposits -- 10.4.3 Ripple cross-laminated facies -- 10.4.4 Dunes -- 10.4.5 Antidunes -- 10.4.6 Scour and minor channel fills -- 10.4.7 Gravel sheets -- 10.4.8 Silt and mud drapes -- 10.4.9 Hyperconcentrated flow deposits -- 10.5 Gravitational mass movement deposits and syn-sedimentary deformation structures -- 10.5.1 Overview -- 10.5.2 Fall deposits -- 10.5.3 Slide and slump deposits -- 10.5.4 Debris (sediment-gravity) flow deposits -- 10.5.5 Turbidites -- 10.5.6 Clastic dykes and hydrofracture fills -- 10.6 Glacimarine and glacilacustrine deposits -- 10.6.1 Water body characteristics and sediment influx -- 10.6.2 Depositional processes -- 10.6.3 Varves and other glacilacustrine overflow/interflow deposits -- 10.6.4 Laminated glacimarine sediments -- 10.6.5 Ice-rafted debris and undermelt deposits -- 10.6.6 Iceberg grounding structures and sediments -- 10.6.7 Fossiliferous deposits and biogenic oozes -- 10.7 Winnowing structures (lags, coquinas and boulder pavements) -- 11 Sediment-Landform Associations. , 11.1 Introduction.
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  • 2
    Online Resource
    Online Resource
    London :Grosvenor House Publishing Limited,
    Keywords: Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (175 pages)
    Edition: 1st ed.
    ISBN: 9781781480823
    Series Statement: Cholesterol Series ; v.1
    Language: English
    Note: Cover -- Title -- Dedication -- Medical liability disclaimer -- Table of contents -- Introduction -- How to use this book -- Chapter 1 It's never been proved that high cholesterol causes heart disease -- Chapter 2 Dietary cholesterol and saturated fat lower the rates of heart disease -- Chapter 3 High cholesterol levels help you live longer -- Chapter 4 What does cause heart disease? -- Chapter 5 Comment by eminent professors and doctors -- Chapter 6 Summary of the evidence -- Appendix 1 Glossary -- Appendix 2 Further resources -- Appendix 3 List of studies -- Index -- Copyright.
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  • 3
    Online Resource
    Online Resource
    Bloomington :Indiana University Press,
    Keywords: Hadrosauridae. ; Hadrosauridae--Anatomy. ; Hadrosauridae--Geographical distribution. ; Dinosaurs. ; Electronic books.
    Description / Table of Contents: The 36 chapters are divided into six sections--an overview, new insights into hadrosaur origins, hadrosaurid anatomy and variation, biogeography and biostratigraphy, function and growth, and preservation, tracks, and traces--followed by an afterword by Jack Horner.
    Type of Medium: Online Resource
    Pages: 1 online resource (640 pages)
    Edition: 1st ed.
    ISBN: 9780253013903
    Series Statement: Life of the Past Series
    DDC: 567.914
    Language: English
    Note: Cover -- Contents -- Contributors -- Reviewers -- Preface -- Acknowledgments -- Part 1. Overview -- 1 A History of the Study of Ornithopods: Where Have We Been? Where Are We Now? and Where Are We Going? -- Part 2. New Insights into Hadrosaur Origins -- 2 Iguanodonts from the Wealden of England: Do They Contribute to the Discussion Concerning Hadrosaur Origins? -- 3 Osteology of the Basal Hadrosauroid Equijubus normani (Dinosauria, Ornithopoda) from the Early Cretaceous of China -- 4 Gongpoquansaurus mazongshanensis (Lü, 1997) comb. nov. (Ornithischia: Hadrosauroidea) from the Early Cretaceous of Gansu Province, Northwestern China -- 5 Postcranial Anatomy of a Basal Hadrosauroid (Dinosauria: Ornithopoda) from the Cretaceous (Cenomanian) Woodbine Formation of North Texas -- 6 A Re-evaluation of Purported Hadrosaurid Dinosaur Specimens from the "Middle" Cretaceous of England -- 7 A New Hadrosauroid (Plesiohadros djadokhtaensis) from the Late Cretaceous Djadokhtan Fauna of Southern Mongolia -- 8 Hadrosauroid Material from the Santonian Milk River Formation of Southern Alberta, Canada -- Part 3. Hadrosaurid Anatomy and Variation -- 9 New Hadrosaurid (Dinosauria, Ornithopoda) Specimens from the Lower-Middle Campanian Wahweap Formation of Southern Utah -- 10 New Saurolophine Material from the Upper Campanian-Lower Maastrichtian Wapiti Formation, West-Central Alberta -- 11 Variation in the Skull Roof of the Hadrosaur Gryposaurus Illustrated by a New Specimen from the Kaiparowits Formation (late Campanian) of Southern Utah -- 12 A Skull of Prosaurolophus maximus from Southeastern Alberta and the Spatiotemporal Distribution of Faunal Zones in the Dinosaur Park Formation -- 13 Postcranial Anatomy of Edmontosaurus regalis (Hadrosauridae) from the Horseshoe Canyon Formation, Alberta, Canada. , 14 Cranial Morphology and Variation in Hypacrosaurus stebingeri (Ornithischia: Hadrosauridae) -- Part 4. Biogeography and Biostratigraphy -- 15 An Overview of the Latest Cretaceous Hadrosauroid Record in Europe -- 16 The Hadrosauroid Record in the Maastrichtian of the Eastern Tremp Syncline (Northern Spain) -- 17 Hadrosaurs from the Far East: Historical Perspective and New Amurosaurus Material from Blagoveschensk (Amur Region, Russia) -- 18 South American Hadrosaurs: Considerations on Their Diversity -- 19 The Hadrosaurian Record from Mexico -- 20 Stratigraphic Distribution of Hadrosaurids in the Upper Cretaceous Fruitland, Kirtland, and Ojo Alamo Formations, San Juan Basin, New Mexico -- 21 Relocating the Lost Gryposaurus incurvimanus Holotype Quarry, Dinosaur Provincial Park, Alberta, Canada -- Part 5. Function and Growth -- 22 Comparative Ontogenies (Appendicular Skeleton) for Three Hadrosaurids and a Basal Iguanodontian: Divergent Developmental Pathways in Hadrosaurinae and Lambeosaurinae -- 23 The Size-Frequency Distribution of Hadrosaurs from the Dinosaur Park Formation of Alberta, Canada -- 24 Osteohistology and Occlusal Morphology of Hypacrosaurus stebingeri Teeth throughout Ontogeny with Comments on Wear-Induced Form and Function -- 25 Three-Dimensional Computational Modeling of Pelvic Locomotor Muscle Moment Arms in Edmontosaurus (Dinosauria, Hadrosauridae) and Comparisons with Other Archosaurs -- 26 Duckbills on the Run: The Cursorial Abilities of Hadrosaurs and Implications for Tyrannosaur-Avoidance Strategies -- 27 Duck Soup: The Floating Fates of Hadrosaurs and Ceratopsians at Dinosaur Provincial Park -- 28 Hadrosauroid Jaw Mechanics and the Functional Significance of the Predentary Bone -- Part 6. Preservation, Tracks, and Traces. , 29 Debris Flow Origin of an Unusual Late Cretaceous Hadrosaur Bonebed in the Two Medicine Formation of Western Montana -- 30 Occurrence and Taphonomy of the First Documented Hadrosaurid Bonebed from the Dinosaur Park Formation (Belly River Group, Campanian) at Dinosaur Provincial Park, Alberta, Canada -- 31 Body Size Distribution in a Death Assemblage of a Colossal Hadrosaurid from the Upper Cretaceous of Zhucheng, Shandong Province, China -- 32 First Hadrosaur Trackway from the Upper Cretaceous (Late Campanian) Oldman Formation, Southeastern Alberta -- 33 Paleopathology in Late Cretaceous Hadrosauridae from Alberta, Canada -- 34 A Review of Hadrosaurid Skin Impressions -- 35 Soft-Tissue Structures of the Nasal Vestibular Region of Saurolophine Hadrosaurids (Dinosauria, Ornithopoda) Revealed in a "Mummified" Specimen of Edmontosaurus annectens -- 36 The Role and Biochemistry of Melanin Pigment in the Exceptional Preservation of Hadrosaur Skin -- Afterword -- Subject Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- L -- M -- N -- O -- P -- R -- S -- T -- Locality Index (by country) -- A -- B -- C -- F -- G -- I -- M -- P -- R -- S -- U -- Stratigraphy Index (by country) -- A -- B -- C -- F -- G -- I -- M -- N -- R -- S -- U -- Taxonomic Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- R -- S -- T -- U -- V -- W -- X -- Y -- Z.
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  • 4
    Online Resource
    Online Resource
    Newark :John Wiley & Sons, Incorporated,
    Keywords: Plant genomes. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (299 pages)
    Edition: 1st ed.
    ISBN: 9781118472491
    Series Statement: Annual Plant Reviews Series
    Language: English
    Note: Intro -- Annual Plant Reviews Volume 46 -- Contents -- List of Contributors -- Preface -- Acknowledgements -- 1 Introduction: Mysteries, Molecules and Mechanisms -- 1.1 Darwin and Margulis revisited -- 1.2 Nuclei-general features -- 1.3 The plant nuclear genome -- 1.3.1 General features -- 1.3.2 Replication of the nuclear genome -- 1.4 DNA inside, ribosomes outside -- 1.5 Concluding comments on the evolution of the nucleus -- References -- 2 The Nuclear Envelope-Structure and Protein Interactions -- 2.1 Introduction -- 2.2 Organization and structure of the plant nuclearenvelope -- 2.3 Proteins of the plant nuclear envelope -- 2.3.1 Proteins involved in signalling -- 2.3.2 Proteins of the nuclear pore complex -- 2.3.3 Proteins of the INM -- 2.3.4 Proteins spanning the periplasm and linking the NE membranes -- 2.3.5 The plant lamina -- 2.4 The plant nuclear envelope and the nucleoskeleton -- attachments at the INM -- 2.5 The plant nuclear envelope and the cytoskeleton -- attachments at the ONM -- 2.6 Targeting of proteins to the plant NE -- 2.7 Nuclear envelope protein dynamics in mitosis -- 2.7.1 The role of NPC in regulating NE dynamics in cell division -- 2.7.2 NE protein dynamics in division -- 2.8 The phragmoplast and cell plate and their relationship to the NE -- 2.9 The plant NE in meiosis -- 2.10 Lipid composition of the plant NE and its homeostasis -- 2.10.1 Nuclear-vacuolar junctions and lipid homeostasis -- 2.10.2 NE phospholipid regulation by lipins -- 2.11 The role of plant NE components in stress responses -- 2.11.1 Nuclei repositioning in response to environmental stimuli -- 2.11.2 Functions of the plant NE during viral infection -- 2.12 Concluding remarks -- Acknowledgements -- References -- 3 The Plant Nuclear Pore Complex - The Nucleocytoplasmic Barrierand Beyond -- 3.1 Nuclear pore complex structure -- 3.1.1 Structure of the NPC. , 3.1.2 Molecular composition of the NPC -- 3.1.3 Nucleocytoplasmic trafficking -- 3.1.3.1 Karyopherins and Ran cycle -- 3.1.3.2 Non-karyopherin transport -- 3.1.3.3 Models explaining 'virtual gating' of the NPC -- 3.2 Physiological and developmental roles of plant nuclear pore components -- 3.2.1 Plant-microbe interactions -- 3.2.2 Hormone responses -- 3.2.2.1 Abscisic acid signalling -- 3.2.2.2 Auxin signalling -- 3.2.3 Abiotic stress responses -- 3.2.3.1 Temperature stress -- 3.2.3.2 Salt and osmotic stress -- 3.2.4 Growth and development -- 3.3 The Dynamics of the Nuclear Pore Complex -- 3.3.1 Types of mitosis -- 3.3.2 NPC disassembly and dynamics of animal NPC components -- 3.3.3 Dynamics of fungal NPC components -- 3.3.4 Dynamics of plant NPC components -- 3.4 Conclusions -- References -- 4 Nucleoskeleton in Plants: The Functional Organization of Filaments in the Nucleus -- 4.1 Introduction -- 4.2 Intermediate filaments and the nucleoskeleton -- 4.3 Plants do not have intermediate filaments but they may have functional equivalents -- 4.4 Plants can evolve different solutions to the same problem -- 4.5 Intermediate filaments first evolved in the nucleus -- 4.6 Plants require a rigid nuclear boundary -- 4.7 Is there a trans-nuclear envelope complex in plants that links the nucleoskeleton to the cytoskeleton? -- 4.8 Role of the nuclear lamina as part of the nucleoskeleton -- 4.9 Structural evidence for the nucleoskeleton -- 4.10 NuMA in plants -- 4.11 Matrix attachment regions (MARs) and the role of the nucleoskeleton in chromatin organization -- 4.12 Chromocentres and the plant nucleoskeleton -- 4.13 Long coiled-coil proteins in plants and their role in nuclear organization: candidates for plamins and nucleoskeletal proteins? -- 4.14 Actin and microtubules in the nucleus -- 4.15 Conclusions -- Acknowledgements -- References. , 5 Genomics and Chromatin Packaging -- 5.1 Chromatin components and structure in highereukaryotes -- 5.2 Histones and nucleosome fibre -- 5.2.1 Histone variants -- 5.2.2 Histone modifications -- 5.2.3 Nucleosome dynamics -- 5.3 Linker histone and the higher order chromatin-order fibre -- 5.3.1 The elusive higher order chromatin fibre -- 5.4 Chromatin loops and chromosome axis -- 5.5 Conclusions and future prospects -- References -- 6 Heterochromatin Positioning and Nuclear Architecture -- 6.1 Heterochromatin structure -- 6.1.1 Heterochromatic sequences -- 6.1.2 Epigenetic marks -- 6.1.2.1 DNA methylation -- 6.1.2.2 Histone code -- 6.1.2.3 Histone-repressive marks -- 6.1.2.4 Histone-activating marks -- 6.1.2.5 Histone variants -- 6.1.2.6 Non-coding RNA -- 6.1.3 Non-histone protein binding -- 6.1.4 Heterochromatin is an epigenetic state -- 6.2 Heterochromatin organization -- 6.2.1 Heterochromatin and nuclear architecture -- 6.2.1.1 Chromosome territories in Arabidopsis -- 6.2.1.2 Chromocentres and the rosette-loop model of chromatin organization -- 6.2.1.3 Chromatin organization in large genome species -- 6.2.2 Recruitment of heterochromatin at the nuclear periphery -- 6.2.2.1 The central role of lamins in animals -- 6.2.2.2 The inner nuclear membrane and heterochromatin -- 6.2.2.3 Heterochromatin positioning in plants -- 6.2.3 Higher order of chromatin organization -- 6.2.3.1 Boundary elements -- 6.2.3.2 Condensin and cohesin -- 6.2.3.3 Matrix Attachment Regions -- 6.2.3.4 Future prospects in plants -- 6.3 Functional significance of heterochromatin positioning -- 6.3.1 Centric heterochromatin directs chromosome segregation -- 6.3.2 Spatial positioning of heterochromatin affects transcriptional activity -- 6.3.3 Heterochromatin positioning protects against genomeinstability -- 6.4 Perspectives -- Acknowledgements -- References. , 7 Telomeres in Plant Meiosis: Their Structure, Dynamics and Function -- 7.1 Introduction -- 7.1.1 The meiotic pathway -- 7.1.2 Arabidopsis thaliana as a model for meiosis -- 7.2 The telomeres and associated proteins -- 7.2.1 Telomere binding proteins -- 7.2.2 Arabidopsis telomere binding proteins -- 7.2.3 DNA repair proteins -- 7.3 The behaviour of the telomeres in meiosis -- 7.3.1 The bouquet -- 7.3.2 A role for the bouquet -- 7.4 Telomere dynamics in Arabidopsis thaliana meiosis -- 7.4.1 Meiosis in A. thaliana telomere-deficient lines -- 7.5 How are the telomeres moved in meiotic prophase I? -- 7.5.1 Colchicine disrupts meiotic progression -- 7.5.2 The role of actin in telomere movement -- 7.6 Components of the nuclear envelope -- 7.7 Components of the plant nuclear envelope -- 7.8 Conclusions and future prospects -- Acknowledgements -- References -- 8 The Nuclear Pore Complex in Symbiosis and Pathogen Defence -- 8.1 Introduction -- 8.2 The nuclear pore and plant-microbe symbiosis -- 8.2.1 Common signalling in arbuscular mycorrhiza and root-nodule symbiosis -- 8.2.2 Symbiotic signalling at the nucleus -- 8.2.3 Symbiotic defects in ljnup85, ljnup133 and nena mutants -- 8.2.4 How do nucleoporins function in plant-microbe symbiosis? -- 8.3 The nuclear pore and plant defence -- 8.3.1 Plant immune responses can be triggered by pathogen-associated molecular patterns and microbial effectors -- 8.3.2 AtNUP88 and AtNUP96 are required for basal and NB-LRR-mediated plant immunity -- 8.3.3 Mechanisms of nucleoporin-mediated plant defence signalling -- 8.4 Specificity, redundancy and general functions of plant nucleoporins -- 8.4.1 The NUP107-160 sub-complex -- 8.4.2 Hormone signalling -- 8.4.3 Development, flowering time, stress tolerance and RNA transport -- 8.5 Challenges and conclusion -- References -- Index -- Supplemental Images.
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  • 5
    Publication Date: 2013-12-10
    Description: Background: Dihydroorotase (DHO) is a zinc metalloenzyme, although the number of active site zinc ions has been controversial. E. coli DHO was initially thought to have a mononuclear metal center, but the subsequent X-ray structure clearly showed two zinc ions, alpha and beta, at the catalytic site. Aquifex aeolicus DHO, is a dodecamer comprised of six DHO and six aspartate transcarbamoylase (ATC) subunits. The isolated DHO monomer, which lacks catalytic activity, has an intact alpha-site and conserved beta-site ligands, but the geometry of the second metal binding site is completely disrupted. However, the putative beta-site is restored when the complex with ATC is formed and DHO activity is regained. Nevertheless, the X-ray structure of the complex revealed a single zinc ion at the active site. The structure of DHO from the pathogenic organism, S. aureus showed that it also has a single active site metal ion. Results: Zinc analysis showed that the enzyme has one zinc/DHO subunit and the addition of excess metal ion did not stimulate catalytic activity, nor alter the kinetic parameters. The metal free apoenzyme was inactive, but the full activity was restored upon the addition of one equivalent of Zn2+ or Co2+. Moreover, deletion of the beta-site by replacing the His180 and His232 with alanine had no effect on catalysis in the presence or absence of excess zinc. The 2.2 A structure of the double mutant confirmed that the beta-site was eliminated but that the active site remained otherwise intact. Conclusions: Thus, kinetically competent A. aeolicus DHO has a mononuclear metal center. In contrast, elimination of the putative second metal binding site in amidohydrolyases with a binuclear metal center, resulted in the abolition of catalytic activity. The number of active site metal ions may be a consideration in the design of inhibitors that selectively target either the mononuclear or binuclear enzymes.
    Electronic ISSN: 1471-2091
    Topics: Chemistry and Pharmacology
    Published by BioMed Central
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  • 6
    Publication Date: 2012-12-14
    Description: Background: Severe hypoglycaemia (SH) is one of the most feared complications of type 1 diabetes (T1DM) with a reported prevalence of nearly 40%. In randomized trials of Multiple Daily Injections (MDI) and Continuous Subcutaneous Insulin Infusion (CSII) therapy there is a possible benefit of CSII in reducing SH. However few trials have used basal insulin analogues as the basal insulin in the MDI group and individuals with established SH have often been excluded from prospective studies. In published studies investigating the effect of Real Time Continuous Glucose Monitoring (RT-CGM) benefit in terms of reduced SH has not yet been demonstrated. The primary objective of this study is to elucidate whether in people with T1DM complicated by impaired awareness of hypoglycaemia (IAH), rigorous prevention of biochemical hypoglycaemia using optimized existing self-management technology and educational support will restore awareness and reduce risk of recurrent SH. Methods: This is a multicentre prospective RCT comparing hypoglycaemia avoidance with optimized MDI and CSII with or without RT-CGM in a 2x2 factorial design in people with type 1 diabetes who have IAH. The primary outcome measure for this study is the difference in IAH (Gold score) at 24 weeks. Secondary outcomes include biomedical measures such as HbA1c, SH incidence, blinded CGM analysis, self monitored blood glucose (SMBG) and response to hypoglycaemia in gold standard clamp studies. Psychosocial measures including well-being and quality of life will also be assessed using several validated and novel measures. Analysis will be on an intention-to-treat basis.DiscussionMost existing RCTs using this study's interventions have been powered for change in HbA1c rather than IAH or SH. This trial will demonstrate whether IAH can be reversed and SH prevented in people with T1DM in even those at highest risk by using optimized conventional management and existing technology.Trial Registration: ISRCTN52164803 Eudract No: 2009-015396-27
    Electronic ISSN: 1472-6823
    Topics: Medicine
    Published by BioMed Central
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  • 7
    Publication Date: 2012-11-30
    Description: Nature Geoscience 5, 836 (2012). doi:10.1038/ngeo1645 Authors: Kevin J. Anchukaitis, Petra Breitenmoser, Keith R. Briffa, Agata Buchwal, Ulf Büntgen, Edward R. Cook, Rosanne D. D'Arrigo, Jan Esper, Michael N. Evans, David Frank, Håkan Grudd, Björn E. Gunnarson, Malcolm K. Hughes, Alexander V. Kirdyanov, Christian Körner, Paul J. Krusic, Brian Luckman, Thomas M. Melvin, Matthew W. Salzer, Alexander V. Shashkin, Claudia Timmreck, Eugene A. Vaganov & Rob J. S. Wilson
    Print ISSN: 1752-0894
    Electronic ISSN: 1752-0908
    Topics: Geosciences
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  • 8
    Publication Date: 2014-01-14
    Description: Oligoâ p âphenylene ethynylenes have been shown to be useful for their sensing and biocidal capabilities. In this study, we examine the influence of interfacial water on the photophysical properties of a carboxyesterâsubstituted compound in this class through analysis of the aggregation with ionic surfactants, solvent isotope effects, and classical molecular dynamics simulations. The results of this study reveal that the presence of carboxyester groups leads to highly structured interfacial water and results in quenched fluorescence. In addition, the results indicate that hydrogen bonding is essential for aggregate formation. Copyright © 2014 John Wiley & Sons, Ltd. The influence of Hâbonding with aqueous solvent on the fluorescence of an oligoâpâphenylene ethynylene was explored using a combined experimental and computational approach. Fluorescence spectra and lifetimes were compared in deuterium oxide and water, and complexation with an ionic surfactant revealed striking changes in fluorescence and absorbance spectra. Classical molecular dynamics studies revealed and extended Hâbonding networks are involved in surfactant complexation. The results of this study reveal the importance of the carboxyester moiety and Hâbonding in fluorescent sensors.
    Print ISSN: 0894-3230
    Electronic ISSN: 1099-1395
    Topics: Chemistry and Pharmacology , Physics
    Published by Wiley-Blackwell
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  • 9
    Publication Date: 2011-05-01
    Description: Idealized conceptual models of supercontinent cyclicity must be tested against the geologic record using pre-Pangean reconstructions. We integrate tectonostratigraphic records and paleomagnetic data from Siberia, Laurentia, and Baltica to produce a quantitative reconstruction of the core of the Nuna supercontinent at 1.9-1.3 Ga. In our model, the present southern and eastern margins of Siberia juxtapose directly adjacent to, respectively, the arctic margin of Laurentia and the Uralian margin of Baltica. Consistent tectonostratigraphic records of the three cratons collectively indicate the history of Nuna's assembly and breakup. According to this reconstruction, the late Mesoproterozoic transition from Nuna to Rodinia appears to have been much less dramatic than the subsequent late Neoproterozoic transition from Rodinia to Gondwana.
    Print ISSN: 0091-7613
    Electronic ISSN: 1943-2682
    Topics: Geosciences
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  • 10
    Publication Date: 2011-01-01
    Description: Previous paleomagnetic work has appeared to demand the breakup of southwest United States-East Antarctic (SWEAT) type Rodinia reconstructions before ca. 750 Ma, significantly earlier than the stratigraphic record of rift-drift transition between 715 Ma and 650 Ma. Here we reanalyze Australian paleomagnetic and regional tectonic data to produce a model in which the Precambrian Australian continent had a slightly different configuration before the breakup of Rodinia. A cross-continental megashear zone developed along the Paterson and Petermann orogens at ca. 650-550 Ma, during or after the breakup of Rodinia, manifested as an [~]40{degrees} clockwise rotation of the South and West Australian cratons relative to the North Australian craton around a vertical axis in Central Australia. This model reconciles major paleomagnetic discrepancies within Australia, and allows for a longer lifespan of SWEAT-like reconstructions of Rodinia that are consistent with the Neoproterozoic stratigraphic records of Australia and Laurentia.
    Print ISSN: 0091-7613
    Electronic ISSN: 1943-2682
    Topics: Geosciences
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